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学科主题: 临床医学
题名:
Efficacy and safety of FIREHAWK (R) abluminal groove filled biodegradable polymer sirolimus-eluting stents for the treatment of long coronary lesions: nine-month angiographic and one-year clinical results from TARGET I trial long cohort
作者: Xu Bo1; Gao Run-lin1,3; Zhang Rui-yan4; Wang Hai-chang5; Li Zhan-quan; Yang Yue-jin1; Ma Chang-sheng7; Han Ya-ling8; Lansky, Alexandra J.9; Huo Yong10; Li Wei2; Leon, Martin B.11,12
关键词: sirolimus ; drug-eluting stents ; biodegradable ; coronary artery disease
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2013-03-20
DOI: 10.3760/cma.j.issn.0366-6999.20123206
卷: 126, 期:6, 页:1026-1032
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: ARTERY-DISEASE ; RANDOMIZED-TRIAL ; RESTENOSIS ; IMPLANTATION ; METAANALYSIS ; MULTICENTER ; PLACEMENT ; OCCLUSION ; THERAPY ; LENGTH
英文摘要:

Background Previous studies indicated that long coronary lesions are one of the key predictors of drug-eluting stent (DES) failure. The purpose of this study was to evaluate the efficacy and the safety of the long length FIREHAWK (R) stent in long coronary artery disease.

Methods The long cohort of TARGET I was a prospective, multicenter, single arm trial. It was planned to enroll 50 patients undergoing percutaneous coronary intervention (PCI) for the treatment of de novo long lesions in a native coronary artery. The major inclusion criteria of the trial was that patients were intended to undergo the treatment of a long target lesion(s) with diameter stenosis >= 70% and reference vessel diameter 2.5 mm to 4.0 mm by visual estimate, that needed to be covered by at least one 33 mm or 38 mm stent or multiple long stents overlapped. The angiographic follow-up was planned at 9-month and the clinical follow-up will be up to 5 years. The primary end point was in-stent late lumen loss at 9-month.

Results Fifty patients (mean age (57.6 +/- 10.2) years) with 59 de novo long lesions (reference vessel diameter (2.85 +/- 0.44) mm, lesion length (35.2 +/- 9.4) mm, and stent length (41.8 +/- 11.3) mm) were enrolled. The angiographic follow-up rate was 92% at 9-month. The in-stent late loss was (0.16 +/- 0.16) mm. Proximal edge, distal edge and in-segment late loss (mm) were 0.21 +/- 0.35, 0.03 +/- 0.33, and 0.07 +/- 0.26, respectively. No in-segment binary restenosis was observed. At 1-year no death, Q wave myocardial infarction (MI), or stent thrombosis occurred. Non-Q-wave MI occurred in two patients (4%) due to procedural complications.

Conclusions Treatment of long coronary lesions with the FIREHAWK (R) stent is able to produce similar results as observed in the FIREHAWK (R) FIM clinical trial. Based on this result, we are confident in the treatment prospect of the FIREHAWK (R) for long coronary lesions.

语种: 英语
WOS记录号: WOS:000319783700006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57873
Appears in Collections:北京大学第一临床医学院_心血管内科_期刊论文

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作者单位: 1.Peiking Union Med Coll, Beijing 100037, Peoples R China
2.Yale New Haven Med Ctr, New Haven, CT 06504 USA
3.Columbia Univ, Med Ctr, New York, NY USA
4.Cardiovasc Res Fdn, New York, NY USA
5.Chinese Acad Med Sci, Dept Cardiol, Fu Wai Hosp, Natl Ctr Cardiovasc Dis China, Beijing 100037, Peoples R China
6.Chinese Acad Med Sci, Div Biometr, Fu Wai Hosp, Natl Ctr Cardiovasc Dis China, Beijing 100037, Peoples R China
7.Shanghai Jiao Tong Univ, Sch Med, Affiliated Ruijin Hosp, Dept Cardiol, Shanghai 200025, Peoples R China
8.Fourth Mil Med Univ, Affiliated Xijing Hosp, Dept Cardiol, Xian 710032, Shaanxi, Peoples R China
9.Liaoning Prov Peoples Hosp, Dept Cardiol, Shenyang 110016, Liaoning, Peoples R China
10.Capital Med Univ, Affiliated An Zhen Hosp, Dept Cardiol, Beijing 100029, Peoples R China
11.Shenyang Northern Hosp, Dept Cardiol, Shenyang 110015, Liaoning, Peoples R China
12.Peking Univ, Hosp 1, Dept Cardiol, Beijing 100034, Peoples R China

Recommended Citation:
Xu Bo,Gao Run-lin,Zhang Rui-yan,et al. Efficacy and safety of FIREHAWK (R) abluminal groove filled biodegradable polymer sirolimus-eluting stents for the treatment of long coronary lesions: nine-month angiographic and one-year clinical results from TARGET I trial long cohort[J]. CHINESE MEDICAL JOURNAL,2013,126(6):1026-1032.
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