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学科主题: 临床医学
题名:
Insulin-Like Growth Factor 1 Receptor Is a Prognostic Factor in Classical Hodgkin Lymphoma
作者: Liang, Zheng1,2,3,4; Diepstra, Arjan1,2; Xu, Chuanhui5; van Imhoff, Gustaaf2,6; Plattel, Wouter1,2; Van Den Berg, Anke1,2; Visser, Lydia1,2
刊名: PLOS ONE
发表日期: 2014-01-28
DOI: 10.1371/journal.pone.0087474
卷: 9, 期:1
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: FACTOR-I RECEPTOR ; FACTOR TYPE-1 RECEPTOR ; PROSTATE-CANCER CELLS ; HUMAN BREAST-CANCER ; INSULIN-LIKE-GROWTH-FACTOR-1 RECEPTOR ; SIGNAL-TRANSDUCTION ; TYROSINE KINASES ; IGF-I ; EXPRESSION ; SURVIVAL
英文摘要:

The interaction between the tumor cells in classical Hodgkin lymphoma (cHL) and the microenvironment includes aberrant activity of receptor tyrosine kinases. In this study we evaluated the expression, functionality and prognostic significance of Insulin-like growth factor-1 receptor (IGF-1R) in cHL. IGF-1R was overexpressed in 55% (44/80) of cHL patients. Phosphorylated IGF-1R was detectable in a minority of the IGF-1R positive tumor cells. The overall survival (OS, 98%) and 5-year progression-free survival (PFS, 93%) was significantly higher in IGF-1R positive cHL patients compared to IGF-1R negative patients (OS 83%, p = .029 and PFS 77%, p = .047, respectively). Three cHL cell lines showed expression of IGF-1R, with strong staining especially in the mitotic cells and expression of IGF-1. IGF-1 treatment had a prominent effect on the cell growth of L428 and L1236 cells and resulted in an increased phosphorylation of IGF1R, Akt and ERK. Inhibition of IGF-1R with cyclolignan picropodophyllin (PPP) decreased cell growth and induced a G2/M cell cycle arrest in all three cell lines. Moreover, a decrease in pCcd2 and an increase in CyclinB1 levels were observed which is consistent with the G2/M cell cycle arrest. In conclusion, IGF-1R expression in HRS cells predicts a favorable outcome, despite the oncogenic effect of IGF-1R in cHL cell lines.

语种: 英语
项目资助者: Abel Tasman Talent fellowship (UMCG) ; Dutch Cancer Society (KWF) fellowship
WOS记录号: WOS:000330510000136
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57875
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Univ Groningen, Univ Med Ctr Groningen, Dept Pathol & Med Biol, Groningen, Netherlands
2.Univ Groningen, Univ Med Ctr Groningen, NL-9713 AV Groningen, Netherlands
3.Tianjin Med Univ, Canc Inst & Hosp, Canc Cell Biol Lab, Tianjin, Peoples R China
4.Tianjin Med Univ, Gen Hosp, Dept Otolaryngol, Tianjin, Peoples R China
5.Peking Univ, Peoples Hosp, Dept Rheumatol & Immunol, Beijing 100871, Peoples R China
6.Univ Groningen, Univ Med Ctr Groningen, Dept Hematol, Groningen, Netherlands

Recommended Citation:
Liang, Zheng,Diepstra, Arjan,Xu, Chuanhui,et al. Insulin-Like Growth Factor 1 Receptor Is a Prognostic Factor in Classical Hodgkin Lymphoma[J]. PLOS ONE,2014,9(1).
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