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Nitric oxide-mediated neuronal apoptosis in rats with recurrent febrile seizures through endoplasmic reticulum stress pathway
Chen, Jing; Qin, Jiong; Liu, Xiaoyan; Han, Ying; Yang, Zhixian; Chang, Xingzhi; Ji, Xinna
关键词Nitric Oxide Endoplasmic Reticulum Stress Grp78 Caspase-12 Apoptosis Febrile Seizure
刊名NEUROSCIENCE LETTERS
2008-10-10
DOI10.1016/j.neulet.2008.07.060
443期:3页:134-139
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]UNFOLDED PROTEIN RESPONSE ; CELL-DEATH PROGRAM ; CYTOTOXICITY ; CASPASE-12 ; ACTIVATION ; BETA
英文摘要

Nitric oxide (NO), as a neurotransmitter, exerts various physiological and pathological effects on the brain. Excess NO is toxic to neurons and may cause neuronal apoptosis. However, the cascade of NO-mediated apoptosis is not fully understood. We utilized a recurrent febrile seizures (FS) rat model and found that plasma NO was increased, neuronal apoptosis was evident, the expression of glucose-regulated Protein78 (GRP78, a well-established marker of ER stress) was elevated, and caspase-12 (an ER stress-specific proapoptosis molecule) was activated in the hippocampus in a time-dependent manner after recurrent FS. Administration of sodium nitroprusside (SNP, an NO donor) enhanced neuronal apoptosis, down-regulated the expression of GRP78, and increased that of caspase-12 in FS + SNP groups compared with FS groups. In contrast, treatment with N-G-nitrol-L-arginine methyl ester (L-NAME, a competitive NO synthase inhibitor) inhibited neuronal apoptosis, up-regulated the expression of GRP78, and decreased that of caspase-12 in FS + L-NAME groups compared with FS groups. These results suggest that NO mediates neuronal apoptosis caused by recurrent FS, and that the ER stress pathway is involved in NO-mediated neuronal apoptosis. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000259849800005
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被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57881
专题北京大学第一临床医学院_儿科
北京大学第二临床医学院_儿科
作者单位Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China
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GB/T 7714
Chen, Jing,Qin, Jiong,Liu, Xiaoyan,et al. Nitric oxide-mediated neuronal apoptosis in rats with recurrent febrile seizures through endoplasmic reticulum stress pathway[J]. NEUROSCIENCE LETTERS,2008,443(3):134-139.
APA Chen, Jing.,Qin, Jiong.,Liu, Xiaoyan.,Han, Ying.,Yang, Zhixian.,...&Ji, Xinna.(2008).Nitric oxide-mediated neuronal apoptosis in rats with recurrent febrile seizures through endoplasmic reticulum stress pathway.NEUROSCIENCE LETTERS,443(3),134-139.
MLA Chen, Jing,et al."Nitric oxide-mediated neuronal apoptosis in rats with recurrent febrile seizures through endoplasmic reticulum stress pathway".NEUROSCIENCE LETTERS 443.3(2008):134-139.
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