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学科主题: 临床医学
题名:
Nitric oxide-mediated neuronal apoptosis in rats with recurrent febrile seizures through endoplasmic reticulum stress pathway
作者: Chen, Jing; Qin, Jiong; Liu, Xiaoyan; Han, Ying; Yang, Zhixian; Chang, Xingzhi; Ji, Xinna
关键词: nitric oxide ; endoplasmic reticulum stress ; GRP78 ; caspase-12 ; apoptosis ; febrile seizure
刊名: NEUROSCIENCE LETTERS
发表日期: 2008-10-10
DOI: 10.1016/j.neulet.2008.07.060
卷: 443, 期:3, 页:134-139
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: UNFOLDED PROTEIN RESPONSE ; CELL-DEATH PROGRAM ; CYTOTOXICITY ; CASPASE-12 ; ACTIVATION ; BETA
英文摘要:

Nitric oxide (NO), as a neurotransmitter, exerts various physiological and pathological effects on the brain. Excess NO is toxic to neurons and may cause neuronal apoptosis. However, the cascade of NO-mediated apoptosis is not fully understood. We utilized a recurrent febrile seizures (FS) rat model and found that plasma NO was increased, neuronal apoptosis was evident, the expression of glucose-regulated Protein78 (GRP78, a well-established marker of ER stress) was elevated, and caspase-12 (an ER stress-specific proapoptosis molecule) was activated in the hippocampus in a time-dependent manner after recurrent FS. Administration of sodium nitroprusside (SNP, an NO donor) enhanced neuronal apoptosis, down-regulated the expression of GRP78, and increased that of caspase-12 in FS + SNP groups compared with FS groups. In contrast, treatment with N-G-nitrol-L-arginine methyl ester (L-NAME, a competitive NO synthase inhibitor) inhibited neuronal apoptosis, up-regulated the expression of GRP78, and decreased that of caspase-12 in FS + L-NAME groups compared with FS groups. These results suggest that NO mediates neuronal apoptosis caused by recurrent FS, and that the ER stress pathway is involved in NO-mediated neuronal apoptosis. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
所属项目编号: 30571969 ; 985-2-011-24 ; 20040001114 ; 7063096
项目资助者: National Natural Science Foundation of China ; Key Construction Program of the National "985" Project ; Doctoral Program of Higher Education of China ; Beijing Municipal Natural Science Foundation
WOS记录号: WOS:000259849800005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57881
Appears in Collections:北京大学第一临床医学院_儿科_期刊论文

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作者单位: Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China

Recommended Citation:
Chen, Jing,Qin, Jiong,Liu, Xiaoyan,et al. Nitric oxide-mediated neuronal apoptosis in rats with recurrent febrile seizures through endoplasmic reticulum stress pathway[J]. NEUROSCIENCE LETTERS,2008,443(3):134-139.
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