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Assessing the Effect of Treatment Duration on the Association between Anti-Diabetic Medication and Cancer Risk
But, Anna1; Wang, Haining2; Mannisto, Satu3; Pukkala, Eero4; Haukka, Jari1
刊名PLOS ONE
2014-11-24
DOI10.1371/journal.pone.0113162
9期:11
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
资助者European Community ; European Community
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]DETECTION BIAS ; TYPE-2 ; PREVALENCE ; STATEMENT ; ALGORITHM ; MORTALITY ; SMOKING ; FINLAND ; BURDEN ; COHORT
英文摘要

Most studies that have evaluated the association between anti-diabetic medication and cancer risk have suffered from methodological drawbacks. To avoid time-related biases, we evaluated the effect of treatment duration on the cancer risk among naive users of anti-diabetic medication as compared to non-users. In addition, we addressed the influence of common risk factors such as smoking and BMI. The study population comprised 23,394 participants of FINRISK surveys. Data on cancer and anti-diabetic medication were linked with the study cohorts. We applied Lexis tabulation to the data and analyzed split records by using Poisson regression. Changes in cancer incidence in relation to treatment duration were examined by modeling the rate ratio (RR). After a median follow-up of 9 years, 53 cancer cases among users of anti-diabetic medication and 1,028 among non-users were diagnosed. No significant difference in cancer risk between users and non-users was observed after adjustment. The RR for all medication regardless of its duration was 1.01 [95% CI 0.75-1.33], and 1.37 [0.94-1.94] for period of 1-4 years. The results were similar for metformin, sulfonylurea, and insulin. This study demonstrates that evaluation of the variation in cancer risk in relation to treatment duration is of particular importance for enhancing the accuracy of conclusions on the link between exposure to anti-diabetic medication and cancer risk.

语种英语
所属项目编号282526
资助者European Community ; European Community
WOS记录号WOS:000346766900021
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57885
专题北京大学第三临床医学院
作者单位1.Univ Helsinki, Hjelt Inst, Helsinki, Finland
2.Peking Univ, Hosp 3, Dept Endocrinol & Metab, Beijing 100871, Peoples R China
3.Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland
4.Finnish Canc Registry, FIN-00170 Helsinki, Finland
推荐引用方式
GB/T 7714
But, Anna,Wang, Haining,Mannisto, Satu,et al. Assessing the Effect of Treatment Duration on the Association between Anti-Diabetic Medication and Cancer Risk[J]. PLOS ONE,2014,9(11).
APA But, Anna,Wang, Haining,Mannisto, Satu,Pukkala, Eero,&Haukka, Jari.(2014).Assessing the Effect of Treatment Duration on the Association between Anti-Diabetic Medication and Cancer Risk.PLOS ONE,9(11).
MLA But, Anna,et al."Assessing the Effect of Treatment Duration on the Association between Anti-Diabetic Medication and Cancer Risk".PLOS ONE 9.11(2014).
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