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学科主题: 临床医学
题名:
Assessing the Effect of Treatment Duration on the Association between Anti-Diabetic Medication and Cancer Risk
作者: But, Anna1; Wang, Haining2; Mannisto, Satu3; Pukkala, Eero4; Haukka, Jari1
刊名: PLOS ONE
发表日期: 2014-11-24
DOI: 10.1371/journal.pone.0113162
卷: 9, 期:11
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: DETECTION BIAS ; TYPE-2 ; PREVALENCE ; STATEMENT ; ALGORITHM ; MORTALITY ; SMOKING ; FINLAND ; BURDEN ; COHORT
英文摘要:

Most studies that have evaluated the association between anti-diabetic medication and cancer risk have suffered from methodological drawbacks. To avoid time-related biases, we evaluated the effect of treatment duration on the cancer risk among naive users of anti-diabetic medication as compared to non-users. In addition, we addressed the influence of common risk factors such as smoking and BMI. The study population comprised 23,394 participants of FINRISK surveys. Data on cancer and anti-diabetic medication were linked with the study cohorts. We applied Lexis tabulation to the data and analyzed split records by using Poisson regression. Changes in cancer incidence in relation to treatment duration were examined by modeling the rate ratio (RR). After a median follow-up of 9 years, 53 cancer cases among users of anti-diabetic medication and 1,028 among non-users were diagnosed. No significant difference in cancer risk between users and non-users was observed after adjustment. The RR for all medication regardless of its duration was 1.01 [95% CI 0.75-1.33], and 1.37 [0.94-1.94] for period of 1-4 years. The results were similar for metformin, sulfonylurea, and insulin. This study demonstrates that evaluation of the variation in cancer risk in relation to treatment duration is of particular importance for enhancing the accuracy of conclusions on the link between exposure to anti-diabetic medication and cancer risk.

语种: 英语
所属项目编号: 282526
项目资助者: European Community
WOS记录号: WOS:000346766900021
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57885
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: 1.Univ Helsinki, Hjelt Inst, Helsinki, Finland
2.Peking Univ, Hosp 3, Dept Endocrinol & Metab, Beijing 100871, Peoples R China
3.Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland
4.Finnish Canc Registry, FIN-00170 Helsinki, Finland

Recommended Citation:
But, Anna,Wang, Haining,Mannisto, Satu,et al. Assessing the Effect of Treatment Duration on the Association between Anti-Diabetic Medication and Cancer Risk[J]. PLOS ONE,2014,9(11).
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