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Risperidone versus haloperidol in the treatment of acute exacerbations of chronic inpatients with schizophrenia: a randomized double-blind study
Zhang, XY; Zhou, DF; Cao, LY; Zhang, PY; Wu, GY; Shen, YC
关键词Antipsychotic Extrapyramidal Symptoms Haloperidol Risperidone Schizophrenia
刊名INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
2001-11-01
16期:6页:325-330
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]NEGATIVE SYNDROME SCALE ; MULTICENTER ; SEROTONIN ; CLOZAPINE ; RECEPTORS ; DRUGS
英文摘要

The purpose of this study was to compare the efficacy and safety of risperidone and haloperidol in treatment-resistant chronic schizophrenic patients. Subjects (n = 78) who met DSM-III criteria for schizophrenia were randomly assigned to receive 6 mg/day of risperidone or 20 mg/day of haloperidol for 12 weeks. Clinical efficacy was determined using the Positive and Negative Syndrome Scale (PANSS), and side-effects with the Treatment Emergent Symptom Scale (TESS). Risperidone produced a mean 39.8 +/- 24.1% reduction in total PANSS score compared to a mean 28.3 +/- 19.4% reduction in the haloperidol group (P < 0.05). Analysis of changes for the three subscores of the PANSS revealed that the general psychopathology and negative subscores were significantly improved in the risperidone group compared to the haloperidol group. As for the side-effects, the risperidone group showed a significantly lower TESS total score, as well as nervous system symptoms subscore and cardiovascular symptoms subscore, compared to the haloperidol group. Risperidone appears to be a more effective and better tolerated antipsychotic drug in treatment-refractory Chinese schizophrenia than haloperidol. (C) 2001 Lippincott Williams & Wilkins.

语种英语
WOS记录号WOS:000171966300002
引用统计
被引频次:40[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57887
专题北京大学精神卫生研究所
作者单位1.Beijing Med Univ, Inst Mental Hlth, Beijing 100083, Peoples R China
2.Beijing Huilongguan Hosp, Beijing, Peoples R China
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Zhang, XY,Zhou, DF,Cao, LY,et al. Risperidone versus haloperidol in the treatment of acute exacerbations of chronic inpatients with schizophrenia: a randomized double-blind study[J]. INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY,2001,16(6):325-330.
APA Zhang, XY,Zhou, DF,Cao, LY,Zhang, PY,Wu, GY,&Shen, YC.(2001).Risperidone versus haloperidol in the treatment of acute exacerbations of chronic inpatients with schizophrenia: a randomized double-blind study.INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY,16(6),325-330.
MLA Zhang, XY,et al."Risperidone versus haloperidol in the treatment of acute exacerbations of chronic inpatients with schizophrenia: a randomized double-blind study".INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY 16.6(2001):325-330.
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