北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学精神卫生研究所  > 期刊论文
学科主题: 精神卫生
题名:
Risperidone versus haloperidol in the treatment of acute exacerbations of chronic inpatients with schizophrenia: a randomized double-blind study
作者: Zhang, XY; Zhou, DF; Cao, LY; Zhang, PY; Wu, GY; Shen, YC
关键词: antipsychotic ; extrapyramidal symptoms ; haloperidol ; risperidone ; schizophrenia
刊名: INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
发表日期: 2001-11-01
卷: 16, 期:6, 页:325-330
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]: Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]: NEGATIVE SYNDROME SCALE ; MULTICENTER ; SEROTONIN ; CLOZAPINE ; RECEPTORS ; DRUGS
英文摘要:

The purpose of this study was to compare the efficacy and safety of risperidone and haloperidol in treatment-resistant chronic schizophrenic patients. Subjects (n = 78) who met DSM-III criteria for schizophrenia were randomly assigned to receive 6 mg/day of risperidone or 20 mg/day of haloperidol for 12 weeks. Clinical efficacy was determined using the Positive and Negative Syndrome Scale (PANSS), and side-effects with the Treatment Emergent Symptom Scale (TESS). Risperidone produced a mean 39.8 +/- 24.1% reduction in total PANSS score compared to a mean 28.3 +/- 19.4% reduction in the haloperidol group (P < 0.05). Analysis of changes for the three subscores of the PANSS revealed that the general psychopathology and negative subscores were significantly improved in the risperidone group compared to the haloperidol group. As for the side-effects, the risperidone group showed a significantly lower TESS total score, as well as nervous system symptoms subscore and cardiovascular symptoms subscore, compared to the haloperidol group. Risperidone appears to be a more effective and better tolerated antipsychotic drug in treatment-refractory Chinese schizophrenia than haloperidol. (C) 2001 Lippincott Williams & Wilkins.

语种: 英语
WOS记录号: WOS:000171966300002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57887
Appears in Collections:北京大学精神卫生研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Beijing Med Univ, Inst Mental Hlth, Beijing 100083, Peoples R China
2.Beijing Huilongguan Hosp, Beijing, Peoples R China

Recommended Citation:
Zhang, XY,Zhou, DF,Cao, LY,et al. Risperidone versus haloperidol in the treatment of acute exacerbations of chronic inpatients with schizophrenia: a randomized double-blind study[J]. INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY,2001,16(6):325-330.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhang, XY]'s Articles
[Zhou, DF]'s Articles
[Cao, LY]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhang, XY]‘s Articles
[Zhou, DF]‘s Articles
[Cao, LY]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace