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学科主题: 药学
题名:
Acute and sub-chronic toxicity studies of honokiol microemulsion
作者: Zhang, Qianqian1; Li, Jianguo2,3; Zhang, Wei2,3; An, Quan2,3; Wen, Jianhua2,3; Wang, Aiping1; Jin, Hongtao1; Chen, Shizhong4
关键词: Honokiol microemulsion ; Acute toxicity ; Sub-chronic toxicity
刊名: REGULATORY TOXICOLOGY AND PHARMACOLOGY
发表日期: 2015-04-01
DOI: 10.1016/j.yrtph.2014.11.007
卷: 71, 期:3, 页:428-436
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Legal ; Pharmacology & Pharmacy ; Toxicology
研究领域[WOS]: Legal Medicine ; Pharmacology & Pharmacy ; Toxicology
关键词[WOS]: ISCHEMIA-REPERFUSION INJURY ; WEIGHT NATURAL-PRODUCT ; CEREBRAL-ISCHEMIA ; PROTECTS BRAIN ; RATS ; MICE
英文摘要:

The purpose of this study was to investigate the acute and sub-chronic toxicity of honokiol microemulsion. In the acute toxicity tests, the mice were intravenously injected graded doses of honokiol microemulsion and were observed for toxic symptoms and mortality daily for 14 days. In the sub-chronic toxicity study, rats were injected honokiol microemulsion at doses of 100, 500, 2500 mu g/kg body weight (BW) for 30 days. After 30 days treatment and 14 days recovery, the rats were sacrificed for hematological, biochemical and histological examination. In the acute toxicity tests, the estimated median lethal dosage (LD50) was 50.5 mg/kg body weight in mice. In the sub-chronic toxicity tests, the non-toxic reaction dose was 500 mu g/kg body weight. In each treatment group, degeneration or/and necrosis in vascular endothelial cells and structure change of vessel wall can be observed in the injection site (cauda vein) of a few animals while there were no changes in the vessels of other organs. The overall findings of this study indicate that the honokiol microemulsion is non-toxic up to 500 mu g/kg body weight, and it has irritation to the vascular of the injection site which should be paid attention to in clinical medication. (C) 2015 Published by Elsevier Inc.

语种: 英语
所属项目编号: 2009ZX09102-146
项目资助者: National Science and Technology Major Projects for "Major New Drugs Innovation and Development"
WOS记录号: WOS:000352823800008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57888
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Chinese Acad Med Sci, Inst Mat Med, New Drug Safety Evaluat Center, Beijing 100050, Peoples R China
2.China Inst Radiat Protect, Drug Safety Evaluat Ctr, Taiyuan 030006, Peoples R China
3.Shanxi Key Lab Drug Toxicol & Drug Radiat Injury, Taiyuan 030006, Peoples R China
4.Peking Univ, Sch Pharmaceut Sci, Beijing 100191, Peoples R China

Recommended Citation:
Zhang, Qianqian,Li, Jianguo,Zhang, Wei,et al. Acute and sub-chronic toxicity studies of honokiol microemulsion[J]. REGULATORY TOXICOLOGY AND PHARMACOLOGY,2015,71(3):428-436.
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