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Acute and sub-chronic toxicity studies of honokiol microemulsion
Zhang, Qianqian1; Li, Jianguo2,3; Zhang, Wei2,3; An, Quan2,3; Wen, Jianhua2,3; Wang, Aiping1; Jin, Hongtao1; Chen, Shizhong4
关键词Honokiol Microemulsion Acute Toxicity Sub-chronic Toxicity
刊名REGULATORY TOXICOLOGY AND PHARMACOLOGY
2015-04-01
DOI10.1016/j.yrtph.2014.11.007
71期:3页:428-436
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Legal ; Pharmacology & Pharmacy ; Toxicology
资助者National Science and Technology Major Projects for "Major New Drugs Innovation and Development" ; National Science and Technology Major Projects for "Major New Drugs Innovation and Development"
研究领域[WOS]Legal Medicine ; Pharmacology & Pharmacy ; Toxicology
关键词[WOS]ISCHEMIA-REPERFUSION INJURY ; WEIGHT NATURAL-PRODUCT ; CEREBRAL-ISCHEMIA ; PROTECTS BRAIN ; RATS ; MICE
英文摘要

The purpose of this study was to investigate the acute and sub-chronic toxicity of honokiol microemulsion. In the acute toxicity tests, the mice were intravenously injected graded doses of honokiol microemulsion and were observed for toxic symptoms and mortality daily for 14 days. In the sub-chronic toxicity study, rats were injected honokiol microemulsion at doses of 100, 500, 2500 mu g/kg body weight (BW) for 30 days. After 30 days treatment and 14 days recovery, the rats were sacrificed for hematological, biochemical and histological examination. In the acute toxicity tests, the estimated median lethal dosage (LD50) was 50.5 mg/kg body weight in mice. In the sub-chronic toxicity tests, the non-toxic reaction dose was 500 mu g/kg body weight. In each treatment group, degeneration or/and necrosis in vascular endothelial cells and structure change of vessel wall can be observed in the injection site (cauda vein) of a few animals while there were no changes in the vessels of other organs. The overall findings of this study indicate that the honokiol microemulsion is non-toxic up to 500 mu g/kg body weight, and it has irritation to the vascular of the injection site which should be paid attention to in clinical medication. (C) 2015 Published by Elsevier Inc.

语种英语
所属项目编号2009ZX09102-146
资助者National Science and Technology Major Projects for "Major New Drugs Innovation and Development" ; National Science and Technology Major Projects for "Major New Drugs Innovation and Development"
WOS记录号WOS:000352823800008
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57888
Collection北京大学药学院
作者单位1.Chinese Acad Med Sci, Inst Mat Med, New Drug Safety Evaluat Center, Beijing 100050, Peoples R China
2.China Inst Radiat Protect, Drug Safety Evaluat Ctr, Taiyuan 030006, Peoples R China
3.Shanxi Key Lab Drug Toxicol & Drug Radiat Injury, Taiyuan 030006, Peoples R China
4.Peking Univ, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Qianqian,Li, Jianguo,Zhang, Wei,et al. Acute and sub-chronic toxicity studies of honokiol microemulsion[J]. REGULATORY TOXICOLOGY AND PHARMACOLOGY,2015,71(3):428-436.
APA Zhang, Qianqian.,Li, Jianguo.,Zhang, Wei.,An, Quan.,Wen, Jianhua.,...&Chen, Shizhong.(2015).Acute and sub-chronic toxicity studies of honokiol microemulsion.REGULATORY TOXICOLOGY AND PHARMACOLOGY,71(3),428-436.
MLA Zhang, Qianqian,et al."Acute and sub-chronic toxicity studies of honokiol microemulsion".REGULATORY TOXICOLOGY AND PHARMACOLOGY 71.3(2015):428-436.
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