IR@PKUHSC  > 北京大学基础医学院
学科主题基础医学
beta 2 Adrenergic receptor on T lymphocytes and its clinical implications
Fan, Xuelai2; Wang, Yuedan1
关键词Neuroimmunology Beta 2-adrenergic Receptor t Cell Autoimmune
刊名PROGRESS IN NATURAL SCIENCE-MATERIALS INTERNATIONAL
2009-01-10
DOI10.1016/j.pnsc.2008.10.001
19期:1页:17-23
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Materials Science, Multidisciplinary ; Multidisciplinary Sciences
资助者National Natural Science Foundation of China ; Peking University Health Science Center ; National Natural Science Foundation of China ; Peking University Health Science Center
研究领域[WOS]Materials Science ; Science & Technology - Other Topics
关键词[WOS]SINGLE-NUCLEOTIDE POLYMORPHISMS ; BETA-ADRENERGIC-RECEPTORS ; CYTOKINE PRODUCTION ; BETA(2)-ADRENERGIC RECEPTOR ; RHEUMATOID-ARTHRITIS ; B-CELL ; MULTIPLE-SCLEROSIS ; DOWN-REGULATION ; IMMUNE-SYSTEM ; SEPTIC SHOCK
英文摘要

Sustained complex cross-talk between the immune system and the nervous system plays a vital role in retaining homeostasis in a healthy individual. One of the central regulatory mechanisms involved is the existence and functions of beta 2-adrenergic receptors (beta 2AR) on T lymphocytes. This article reviews research progress made recently, including the expression of adrenergic receptors on T lymphocytes, the structure and intracellular pathways of beta 2AR, the activation of beta 2AR by either endogenous or exogenous agonists, and the effect of beta 2AR stimulation on T cells which alters T cell proliferation, differentiation, cytokine production and T-helper-mediated antibody production. Furthermore, we discuss the roles of beta 2AR played in the pathogenesis and treatment of autoimmune diseases. (C) 2008 National Natural Science Foundation of China and Chinese Academy of Sciences. Published by Elsevier Limited and Science in China Press. All rights reserved.

语种英语
所属项目编号J0630850 ; 30671962
资助者National Natural Science Foundation of China ; Peking University Health Science Center ; National Natural Science Foundation of China ; Peking University Health Science Center
WOS记录号WOS:000261837000003
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57893
Collection北京大学基础医学院
作者单位1.Peking Univ, Sch Basic Med Sci, Beijing 100083, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
Recommended Citation
GB/T 7714
Fan, Xuelai,Wang, Yuedan. beta 2 Adrenergic receptor on T lymphocytes and its clinical implications[J]. PROGRESS IN NATURAL SCIENCE-MATERIALS INTERNATIONAL,2009,19(1):17-23.
APA Fan, Xuelai,&Wang, Yuedan.(2009).beta 2 Adrenergic receptor on T lymphocytes and its clinical implications.PROGRESS IN NATURAL SCIENCE-MATERIALS INTERNATIONAL,19(1),17-23.
MLA Fan, Xuelai,et al."beta 2 Adrenergic receptor on T lymphocytes and its clinical implications".PROGRESS IN NATURAL SCIENCE-MATERIALS INTERNATIONAL 19.1(2009):17-23.
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