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学科主题基础医学
Ghrelin Receptor in Energy Homeostasis and Obesity Pathogenesis
Li, Ziru1,2; Li, Yin1,2; Zhang, Weizhen1,2,3; Tao, YX
刊名G PROTEIN-COUPLED RECEPTORS IN ENERGY HOMEOSTASIS AND OBESITY PATHOGENSIS
2013
DOI10.1016/B978-0-12-386933-3.00002-9
114页:45-87
收录类别BSCI ; SCI
文章类型Book Chapter
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology
研究领域[WOS]Biochemistry & Molecular Biology
关键词[WOS]GROWTH-HORMONE SECRETAGOGUE ; PROTEIN-COUPLED RECEPTORS ; BROWN ADIPOSE-TISSUE ; PHARMACOLOGICAL IN-VITRO ; DIET-INDUCED OBESITY ; ENDOCRINE CELL-TYPE ; TIME-RESOLVED FRET ; BODY-WEIGHT GAIN ; FOOD-INTAKE ; INSULIN-RESISTANCE
英文摘要

The ghrelin receptor, also known as growth hormone secretagogue receptor (GHS-R), was identified in porcine and rat anterior pituitary membranes, where the synthetic secretagogue MK-0677 causes amplified pulsatile growth hormone (GH) release. In addition to its function in the stimulation of GH secretion, ghrelin, the natural ligand of ghrelin receptor is now recognized as a peptide hormone with fundamental influence on energy homeostasis. Despite the potential existence of multiple subtypes of ghrelin receptor, the effects of ghrelin on energy metabolism, obesity, and diabetes are mediated by its classical receptor GHS-R1a, whose activation requires the n-octanoylation of ghrelin. Here we review the current understanding of the role of the ghrelin receptor in the regulation of energy homeostasis. An overview of the ghrelin receptor is presented first, followed by the discussion on its effects on food intake, glucose homeostasis, and lipid metabolism. Finally, potential strategies for treating obesity and diabetes via manipulation of the ghrelin/ghrelin receptor axis are explored.

语种英语
WOS记录号WOS:000315745200002
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57895
专题北京大学基础医学院
作者单位1.Peking Univ, Dept Physiol & Pathophysiol, Sch Basic Med Sci, Beijing 100871, Peoples R China
2.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing, Peoples R China
3.Univ Michigan, Dept Surg, Med Ctr, Ann Arbor, MI 48109 USA
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GB/T 7714
Li, Ziru,Li, Yin,Zhang, Weizhen,et al. Ghrelin Receptor in Energy Homeostasis and Obesity Pathogenesis[J]. G PROTEIN-COUPLED RECEPTORS IN ENERGY HOMEOSTASIS AND OBESITY PATHOGENSIS,2013,114:45-87.
APA Li, Ziru,Li, Yin,Zhang, Weizhen,&Tao, YX.(2013).Ghrelin Receptor in Energy Homeostasis and Obesity Pathogenesis.G PROTEIN-COUPLED RECEPTORS IN ENERGY HOMEOSTASIS AND OBESITY PATHOGENSIS,114,45-87.
MLA Li, Ziru,et al."Ghrelin Receptor in Energy Homeostasis and Obesity Pathogenesis".G PROTEIN-COUPLED RECEPTORS IN ENERGY HOMEOSTASIS AND OBESITY PATHOGENSIS 114(2013):45-87.
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