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学科主题: 基础医学
题名:
Ghrelin Receptor in Energy Homeostasis and Obesity Pathogenesis
作者: Li, Ziru1,2; Li, Yin1,2; Zhang, Weizhen1,2,3; Tao, YX
刊名: G PROTEIN-COUPLED RECEPTORS IN ENERGY HOMEOSTASIS AND OBESITY PATHOGENSIS
发表日期: 2013
DOI: 10.1016/B978-0-12-386933-3.00002-9
卷: 114, 页:45-87
收录类别: BSCI ; SCI
文章类型: Book Chapter
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology
研究领域[WOS]: Biochemistry & Molecular Biology
关键词[WOS]: GROWTH-HORMONE SECRETAGOGUE ; PROTEIN-COUPLED RECEPTORS ; BROWN ADIPOSE-TISSUE ; PHARMACOLOGICAL IN-VITRO ; DIET-INDUCED OBESITY ; ENDOCRINE CELL-TYPE ; TIME-RESOLVED FRET ; BODY-WEIGHT GAIN ; FOOD-INTAKE ; INSULIN-RESISTANCE
英文摘要:

The ghrelin receptor, also known as growth hormone secretagogue receptor (GHS-R), was identified in porcine and rat anterior pituitary membranes, where the synthetic secretagogue MK-0677 causes amplified pulsatile growth hormone (GH) release. In addition to its function in the stimulation of GH secretion, ghrelin, the natural ligand of ghrelin receptor is now recognized as a peptide hormone with fundamental influence on energy homeostasis. Despite the potential existence of multiple subtypes of ghrelin receptor, the effects of ghrelin on energy metabolism, obesity, and diabetes are mediated by its classical receptor GHS-R1a, whose activation requires the n-octanoylation of ghrelin. Here we review the current understanding of the role of the ghrelin receptor in the regulation of energy homeostasis. An overview of the ghrelin receptor is presented first, followed by the discussion on its effects on food intake, glucose homeostasis, and lipid metabolism. Finally, potential strategies for treating obesity and diabetes via manipulation of the ghrelin/ghrelin receptor axis are explored.

语种: 英语
WOS记录号: WOS:000315745200002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57895
Appears in Collections:基础医学院_期刊论文

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作者单位: 1.Peking Univ, Dept Physiol & Pathophysiol, Sch Basic Med Sci, Beijing 100871, Peoples R China
2.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing, Peoples R China
3.Univ Michigan, Dept Surg, Med Ctr, Ann Arbor, MI 48109 USA

Recommended Citation:
Li, Ziru,Li, Yin,Zhang, Weizhen,et al. Ghrelin Receptor in Energy Homeostasis and Obesity Pathogenesis[J]. G PROTEIN-COUPLED RECEPTORS IN ENERGY HOMEOSTASIS AND OBESITY PATHOGENSIS,2013,114:45-87.
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