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学科主题: 临床医学
题名:
Influence of pre-pregnancy obesity on the development of macrosomia and large for gestational age in women with or without gestational diabetes mellitus in Chinese population
作者: Wang, L-F1,2; Wang, H-J2,3; Ao, D.2,4; Liu, Z.2,3; Wang, Y.2,3; Yang, H-X1
刊名: JOURNAL OF PERINATOLOGY
发表日期: 2015-12-01
DOI: 10.1038/jp.2015.119
卷: 35, 期:12, 页:985-990
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Obstetrics & Gynecology ; Pediatrics
研究领域[WOS]: Obstetrics & Gynecology ; Pediatrics
关键词[WOS]: BODY-MASS INDEX ; WEIGHT-GAIN ; PREGNANCY OUTCOMES ; INFANTS ; RISK ; HYPERGLYCEMIA ; BIRTHS
英文摘要:

OBJECTIVE: To determine the effects of gestational diabetes mellitus (GDM) and pre-pregnancy obesity on macrosomia and large for gestational age (LGA).

STUDY DESIGN: We conducted a prospective cohort study of 587 GDM women and 478 non-GDM women from 2012 to 2013. We collected their data of the pre-pregnancy weight, sociodemographic data, medical histories, clinical treatment, and followed-up the outcomes of delivery including birth weight. Multiple logistic regression models were used to test associations between pre-pregnant obesity and macrosomia/LGA and between GDM and macrosomia/LGA.

RESULT: Of 1065 women we studied, obese women had 4.17 times and 2.27 times increased risk of developing macrosomia (95% CI: 2.52 to 6.91) and LGA (95% CI: 1.60 to 3.21), respectively, than non-obese women after adjustment for maternal age, gestational weeks and GDM. We did not find GDM is a risk factor for macrosomia or LGA after GDM treatment.

CONCLUSION: Pre-pregnancy obesity accounts for a high prevalence of macrosomia. Interventions that focus on pre-pregnancy obesity have the potential to reach far more women at risk of macrosomia.

语种: 英语
所属项目编号: 20120001110014
项目资助者: Specialized Research Fund for the Doctoral Program of Higher Education
WOS记录号: WOS:000365559000003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57896
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Obstet & Gynecol, Beijing 100871, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Child Adolescent & Womens Hlth, Beijing 100191, Peoples R China
3.Minist Hlth, Key Lab Reprod Hlth, Beijing, Peoples R China
4.Xinjiang Med Univ, Hlth Management Ctr, Xinjiang, Peoples R China

Recommended Citation:
Wang, L-F,Wang, H-J,Ao, D.,et al. Influence of pre-pregnancy obesity on the development of macrosomia and large for gestational age in women with or without gestational diabetes mellitus in Chinese population[J]. JOURNAL OF PERINATOLOGY,2015,35(12):985-990.
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