IR@PKUHSC  > 北京大学公共卫生学院
学科主题公共卫生
Effects of ethanol on mouse embryonic brain development and heat shock protein 73 expression
Jing, H; Li, Y
关键词Ethanol Brain Whole Embryo Culture Heat Shock Protein 73 Mid-brain
刊名TOXICOLOGY IN VITRO
2004-10-01
DOI10.1016/j.tiv.2004.02.004
18期:5页:601-607
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Toxicology
研究领域[WOS]Toxicology
关键词[WOS]RAT EMBRYOS ; CELLS ; INDUCTION ; MIDBRAIN ; PROTEINS ; ISCHEMIA ; CULTURES ; INVITRO ; ALCOHOL ; GROWTH
英文摘要

Effects of ethanol on brain development and heat shock protein 70 (HSP70) expression were investigated in mouse embryos using the whole embryo culture, mid-brain culture, and streptavidin-biotin peroxidase complex (SABC) method. In the whole embryo culture, ethanol (1, 2 and 4 mg/ml) inhibited brain development dose dependently and the most prevalent abnormality was the open cephalic neural tube. At doses of I and 2 mg/ml, ethanol significantly decreased constitutive HSP70 (HSP73) expression level compared to control values in embryonic brain areas. In mid-brain culture, ethanol exposure (from I to 16 mg/ml) during early neuroblast differentiation inhibited neuronal differentiation and proliferation. These results suggest that ethanol may affect embryonic brain development by decreasing HSP73 expression level as well as inhibiting neuronal differentiation and proliferation during the organogenic period. (C) 2004 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000223022500006
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57897
Collection北京大学公共卫生学院
作者单位Peking Univ, Sch Publ Hlth, Lab Mol Toxicol & Dev Mol Biol, Dept Food Sci & Nutr, Beijing 100083, Peoples R China
Recommended Citation
GB/T 7714
Jing, H,Li, Y. Effects of ethanol on mouse embryonic brain development and heat shock protein 73 expression[J]. TOXICOLOGY IN VITRO,2004,18(5):601-607.
APA Jing, H,&Li, Y.(2004).Effects of ethanol on mouse embryonic brain development and heat shock protein 73 expression.TOXICOLOGY IN VITRO,18(5),601-607.
MLA Jing, H,et al."Effects of ethanol on mouse embryonic brain development and heat shock protein 73 expression".TOXICOLOGY IN VITRO 18.5(2004):601-607.
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