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学科主题: 公共卫生
题名:
Effects of ethanol on mouse embryonic brain development and heat shock protein 73 expression
作者: Jing, H; Li, Y
关键词: ethanol ; brain ; whole embryo culture ; heat shock protein 73 ; mid-brain
刊名: TOXICOLOGY IN VITRO
发表日期: 2004-10-01
DOI: 10.1016/j.tiv.2004.02.004
卷: 18, 期:5, 页:601-607
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Toxicology
研究领域[WOS]: Toxicology
关键词[WOS]: RAT EMBRYOS ; CELLS ; INDUCTION ; MIDBRAIN ; PROTEINS ; ISCHEMIA ; CULTURES ; INVITRO ; ALCOHOL ; GROWTH
英文摘要:

Effects of ethanol on brain development and heat shock protein 70 (HSP70) expression were investigated in mouse embryos using the whole embryo culture, mid-brain culture, and streptavidin-biotin peroxidase complex (SABC) method. In the whole embryo culture, ethanol (1, 2 and 4 mg/ml) inhibited brain development dose dependently and the most prevalent abnormality was the open cephalic neural tube. At doses of I and 2 mg/ml, ethanol significantly decreased constitutive HSP70 (HSP73) expression level compared to control values in embryonic brain areas. In mid-brain culture, ethanol exposure (from I to 16 mg/ml) during early neuroblast differentiation inhibited neuronal differentiation and proliferation. These results suggest that ethanol may affect embryonic brain development by decreasing HSP73 expression level as well as inhibiting neuronal differentiation and proliferation during the organogenic period. (C) 2004 Elsevier Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000223022500006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57897
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: Peking Univ, Sch Publ Hlth, Lab Mol Toxicol & Dev Mol Biol, Dept Food Sci & Nutr, Beijing 100083, Peoples R China

Recommended Citation:
Jing, H,Li, Y. Effects of ethanol on mouse embryonic brain development and heat shock protein 73 expression[J]. TOXICOLOGY IN VITRO,2004,18(5):601-607.
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