IR@PKUHSC  > 北京大学深圳医院
学科主题临床医学
Local injury to the endometrium in controlled ovarian hyperstimulation cycles improves implantation rates
Zhou, Liang; Li, Rong1; Wang, Rong; Huang, Hai-xiong; Zhong, Kai
关键词Endometrium Local Injury Pregnancy Gene Chip Expression
刊名FERTILITY AND STERILITY
2008-05-01
DOI10.1016/j.fertnstert.2007.05.064
89期:5页:1166-1176
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Obstetrics & Gynecology ; Reproductive Biology
研究领域[WOS]Obstetrics & Gynecology ; Reproductive Biology
关键词[WOS]IN-VITRO FERTILIZATION ; GENE-EXPRESSION ; GONADOTROPIN ; THICKNESS ; CYTOKINES ; INTEGRINS
英文摘要

Objective: To explore the possibility that local injury to the endometrium in controlled ovarian hyperstimulation cycle improves the incidence of embryo implantation and to analyze the gene expression profile in the endometria of pregnant and nonpregnant patients in in vitro fertilization/embryo transfer (IVF-ET).

Design: Prospective study.

Setting: A clinical assisted reproductive center of a university hospital.

Patient(s): Women undergoing fresh IVF-ET cycles (n=121), treated with a long protocol for controlled ovarian hyperstimulation, whose endometrium were diagnosed by 13-ultrasound showing irregular echo. Intervention(s): Local injury to the endometrium of 60 patients in controlled ovarian hyperstimulation cycle, who were randomly selected from a total of 121 patients. Seven endometrial biopsies samples from day 10 were analyzed by Affymetrix U133 plus 2.0 gene chip.

Main Outcome Measure(s): Outcomes of IVF-ET and gene expression assayed by gene chip technology.

Result(s): Transfer of the same number of embryos (135 in the experimental and control patients, respectively) resulted in rates of implantation (33.33% vs. 17.78%), clinical pregnancy (48.33% vs. 27.86%), and ongoing or live births per ET (41.67% vs. 22.96%) that were higher in the experimental group compared with controls. Statistically significant differences of the expression level of 218 genes (41 up-regulated and 177 down-regulated) were detected in the endometrial biopsy samples from clinical pregnant patients and nonpregnant patients.

Conclusion(s): The results suggested local injury to the endometrium during a COH cycle improved the rates of embryo implantation, clinical pregnancy and live birth in ART. We also demonstrated a statistically significant difference in the messenger RNA (mRNA) expression profiles in the endometrium of pregnant and nonpregnant patients. Further studies on the genes identified herein will assist in predicting implantation competence.

语种英语
WOS记录号WOS:000256075700020
引用统计
被引频次:117[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57901
专题北京大学深圳医院
北京大学第三临床医学院_生殖医学中心
作者单位1.Peking Univ, Shenzhen Hosp, Dept Reprod Med, Med Cent Peking Univ, Shenzhen 518036, Guangdong, Peoples R China
2.Hong Kong Univ Sci & Technol, Shenzhen, Guangdong, Peoples R China
推荐引用方式
GB/T 7714
Zhou, Liang,Li, Rong,Wang, Rong,et al. Local injury to the endometrium in controlled ovarian hyperstimulation cycles improves implantation rates[J]. FERTILITY AND STERILITY,2008,89(5):1166-1176.
APA Zhou, Liang,Li, Rong,Wang, Rong,Huang, Hai-xiong,&Zhong, Kai.(2008).Local injury to the endometrium in controlled ovarian hyperstimulation cycles improves implantation rates.FERTILITY AND STERILITY,89(5),1166-1176.
MLA Zhou, Liang,et al."Local injury to the endometrium in controlled ovarian hyperstimulation cycles improves implantation rates".FERTILITY AND STERILITY 89.5(2008):1166-1176.
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