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学科主题: 临床医学
题名:
Cytogenetic analysis in 16-year follow-up study of a mother and fetus exposed in a radiation accident in Xinzhou, China
作者: Liu, Qing-Jie1; Lu, Xue1; Zhao, Hua1; Chen, Sen2; Wang, Ming-Ming3; Bai, Yushu1; Zhang, Shu-Lan2; Feng, Jiang-Bin1; Zhang, Zhao-hui2; Chen, De-Qing1; Ma, Li-Wen2; Jia, Ting-Zhen2; Liang, Li2
关键词: Radiation accident ; Prenatal exposure ; Cytogenetic analysis ; Fluorescence in situ hybridization ; Dose estimation
刊名: MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
发表日期: 2013-07-04
DOI: 10.1016/j.mrgentox.2013.05.015
卷: 755, 期:1, 页:68-72
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biotechnology & Applied Microbiology ; Genetics & Heredity ; Toxicology
研究领域[WOS]: Biotechnology & Applied Microbiology ; Genetics & Heredity ; Toxicology
关键词[WOS]: IN-SITU HYBRIDIZATION ; CHROMOSOME-ABERRATIONS ; RADIOLOGICAL ACCIDENT ; IONIZING-RADIATION ; 5 VICTIMS ; TRANSLOCATION ; FREQUENCIES ; PERSISTENCE ; DAMAGE ; CELLS
英文摘要:

In November 1992, a radiation accident occurred in Xinzhou, due to the collection by a farmer of an unused Co-60 source; 37 individuals were exposed to ionizing radiation. Three individuals died and the farmer′s 19-weeks-pregnant wife suffered acute radiation symptoms. Conventional chromosome analysis, cytokinesis-block micronuclei (CBMN) assay and fluorescence in situ hybridization (FISH) painting with three pairs of whole chromosome probes were used to analyze chromosomal aberrations for the pregnant female and her baby during the 16 years following the accident. The yields of dicentrics and rings (dic + r) continually declined between 41 days and 16 years after the accident. The frequency of binucleated MN also decreased over time for both mother and daughter. Sixteen years after exposure, the yields of dic + r and binucleated MN decreased to normal levels, but the reciprocal translocation frequencies remained elevated, for both mother and daughter. FISH results showed a decreasing yield of translocations with time. Based on the changes in maternal translocation frequency, the daughter′s dose at the time of exposure was estimated as 1.82 (1.35-2.54) Gy. This was consistent with the clinical manifestations of severe mental retardation and low IQ score. FISH-based translocation analysis can be used for follow-up studies on accidental exposure and, after correction, for retrospective dose estimation for individuals prenatally exposed to radiation. (C) 2013 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 30870749 ; 81172593
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000322856000010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57902
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: 1.Chinese Ctr Dis Control & Prevent, Natl Inst Radiol Protect, China CDC Key Lab Radiol Protect & Nucl Emergency, Beijing 100088, Peoples R China
2.Peking Univ, Hosp 3, Dept Tumor Chemotherapy & Radiat Sickness, Beijing 100191, Peoples R China
3.Anhui Med Univ, Inst Radiat Med, Hefei 230032, Anhui, Peoples R China

Recommended Citation:
Liu, Qing-Jie,Lu, Xue,Zhao, Hua,et al. Cytogenetic analysis in 16-year follow-up study of a mother and fetus exposed in a radiation accident in Xinzhou, China[J]. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS,2013,755(1):68-72.
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