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学科主题临床医学
Cytogenetic analysis in 16-year follow-up study of a mother and fetus exposed in a radiation accident in Xinzhou, China
Liu, Qing-Jie1; Lu, Xue1; Zhao, Hua1; Chen, Sen2; Wang, Ming-Ming3; Bai, Yushu1; Zhang, Shu-Lan2; Feng, Jiang-Bin1; Zhang, Zhao-hui2; Chen, De-Qing1; Ma, Li-Wen2; Jia, Ting-Zhen2; Liang, Li2
关键词Radiation Accident Prenatal Exposure Cytogenetic Analysis Fluorescence In Situ Hybridization Dose Estimation
刊名MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
2013-07-04
DOI10.1016/j.mrgentox.2013.05.015
755期:1页:68-72
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Genetics & Heredity ; Toxicology
研究领域[WOS]Biotechnology & Applied Microbiology ; Genetics & Heredity ; Toxicology
关键词[WOS]IN-SITU HYBRIDIZATION ; CHROMOSOME-ABERRATIONS ; RADIOLOGICAL ACCIDENT ; IONIZING-RADIATION ; 5 VICTIMS ; TRANSLOCATION ; FREQUENCIES ; PERSISTENCE ; DAMAGE ; CELLS
英文摘要

In November 1992, a radiation accident occurred in Xinzhou, due to the collection by a farmer of an unused Co-60 source; 37 individuals were exposed to ionizing radiation. Three individuals died and the farmer′s 19-weeks-pregnant wife suffered acute radiation symptoms. Conventional chromosome analysis, cytokinesis-block micronuclei (CBMN) assay and fluorescence in situ hybridization (FISH) painting with three pairs of whole chromosome probes were used to analyze chromosomal aberrations for the pregnant female and her baby during the 16 years following the accident. The yields of dicentrics and rings (dic + r) continually declined between 41 days and 16 years after the accident. The frequency of binucleated MN also decreased over time for both mother and daughter. Sixteen years after exposure, the yields of dic + r and binucleated MN decreased to normal levels, but the reciprocal translocation frequencies remained elevated, for both mother and daughter. FISH results showed a decreasing yield of translocations with time. Based on the changes in maternal translocation frequency, the daughter′s dose at the time of exposure was estimated as 1.82 (1.35-2.54) Gy. This was consistent with the clinical manifestations of severe mental retardation and low IQ score. FISH-based translocation analysis can be used for follow-up studies on accidental exposure and, after correction, for retrospective dose estimation for individuals prenatally exposed to radiation. (C) 2013 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000322856000010
项目编号30870749 ; 81172593
资助机构National Natural Science Foundation of China
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57902
专题北京大学第三临床医学院
北京大学第三临床医学院_肿瘤治疗中心
作者单位1.Chinese Ctr Dis Control & Prevent, Natl Inst Radiol Protect, China CDC Key Lab Radiol Protect & Nucl Emergency, Beijing 100088, Peoples R China
2.Peking Univ, Hosp 3, Dept Tumor Chemotherapy & Radiat Sickness, Beijing 100191, Peoples R China
3.Anhui Med Univ, Inst Radiat Med, Hefei 230032, Anhui, Peoples R China
推荐引用方式
GB/T 7714
Liu, Qing-Jie,Lu, Xue,Zhao, Hua,et al. Cytogenetic analysis in 16-year follow-up study of a mother and fetus exposed in a radiation accident in Xinzhou, China[J]. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS,2013,755(1):68-72.
APA Liu, Qing-Jie.,Lu, Xue.,Zhao, Hua.,Chen, Sen.,Wang, Ming-Ming.,...&Liang, Li.(2013).Cytogenetic analysis in 16-year follow-up study of a mother and fetus exposed in a radiation accident in Xinzhou, China.MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS,755(1),68-72.
MLA Liu, Qing-Jie,et al."Cytogenetic analysis in 16-year follow-up study of a mother and fetus exposed in a radiation accident in Xinzhou, China".MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS 755.1(2013):68-72.
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