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学科主题: 临床医学
题名:
MR evaluation of cerebral oxygen metabolism and blood flow in stroke-like episodes of MELAS
作者: Wang, Zhaoxia2; Xiao, Jiangxi3; Xie, Sheng1; Zhao, Danhua2; Liu, Xiwei1; Zhang, Jue4; Yuan, Yun2; Huang, Yining2
关键词: Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like pisodes ; Magnetic resonance imaging ; Oxygen extraction fraction ; Cerebral blood flow
刊名: JOURNAL OF THE NEUROLOGICAL SCIENCES
发表日期: 2012-12-15
DOI: 10.1016/j.jns.2012.09.011
卷: 323, 期:1-2, 页:173-177
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology ; Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: MITOCHONDRIAL MYOPATHY ; LACTIC-ACIDOSIS ; GLUCOSE-METABOLISM ; ENCEPHALOPATHY ; PERFUSION ; MUTATION
英文摘要:

Metabolic information is essential in the investigation of the pathophysiology of stroke-like episodes in patients with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS). Here, we used magnetic resonance imaging to evaluate the dynamic metabolic changes before and after a stroke-like episode in two patients with MELAS caused by the mitochondrial DNA mutation A3243G. We performed functional magnetic resonance imaging, including arterial spin labeling and oxygen extraction fraction imaging, and generated cerebral blood flow and oxygen extraction fraction maps. We recruited eight healthy volunteers to define the normal range of the oxygen extraction fraction. We detected a heterogeneous reduction in the oxygen extraction fraction in the brain in the interictal period as well as at the onset of a stroke-like attack. However, the oxygen extraction fraction in the stroke-like lesions normalized in the acute stage. The stroke-like lesions showed consistent hyperperfusion in the acute phase but hypoperfusion in the chronic phase. We have demonstrated the utility of using new magnetic resonance imaging techniques in the evaluation of the pathophysiology of stroke-like lesions. The increased utilization of oxygen in an acute lesion is a novel finding in our study, which might play a role in the oxidative stress. (c) 2012 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 30870864 ; 81201154
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000311132700030
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57904
Appears in Collections:北京大学第一临床医学院_神经内科_期刊论文

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作者单位: 1.China Japan Friendship Hosp, Dept Radiol, Beijing 100029, Peoples R China
2.Peking Univ First Hosp, Dept Neurol, Beijing 100034, Peoples R China
3.Peking Univ First Hosp, Dept Radiol, Beijing 100034, Peoples R China
4.Peking Univ, Adv Acad Interdisciplinary Sci, Beijing 100083, Peoples R China

Recommended Citation:
Wang, Zhaoxia,Xiao, Jiangxi,Xie, Sheng,et al. MR evaluation of cerebral oxygen metabolism and blood flow in stroke-like episodes of MELAS[J]. JOURNAL OF THE NEUROLOGICAL SCIENCES,2012,323(1-2):173-177.
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