IR@PKUHSC  > 北京大学第一临床医学院  > 神经内科
学科主题临床医学
MR evaluation of cerebral oxygen metabolism and blood flow in stroke-like episodes of MELAS
Wang, Zhaoxia2; Xiao, Jiangxi3; Xie, Sheng1; Zhao, Danhua2; Liu, Xiwei1; Zhang, Jue4; Yuan, Yun2; Huang, Yining2
关键词Magnetic Resonance Imaging Mitochondrial Encephalomyopathy Oxygen Extraction Fraction Lactic Acidosis Cerebral Blood Flow And Stroke-like Pisodes
刊名JOURNAL OF THE NEUROLOGICAL SCIENCES
2012-12-15
DOI10.1016/j.jns.2012.09.011
323期:1-2页:173-177
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Clinical Neurology ; Neurosciences
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]MITOCHONDRIAL MYOPATHY ; LACTIC-ACIDOSIS ; GLUCOSE-METABOLISM ; ENCEPHALOPATHY ; PERFUSION ; MUTATION
英文摘要

Metabolic information is essential in the investigation of the pathophysiology of stroke-like episodes in patients with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS). Here, we used magnetic resonance imaging to evaluate the dynamic metabolic changes before and after a stroke-like episode in two patients with MELAS caused by the mitochondrial DNA mutation A3243G. We performed functional magnetic resonance imaging, including arterial spin labeling and oxygen extraction fraction imaging, and generated cerebral blood flow and oxygen extraction fraction maps. We recruited eight healthy volunteers to define the normal range of the oxygen extraction fraction. We detected a heterogeneous reduction in the oxygen extraction fraction in the brain in the interictal period as well as at the onset of a stroke-like attack. However, the oxygen extraction fraction in the stroke-like lesions normalized in the acute stage. The stroke-like lesions showed consistent hyperperfusion in the acute phase but hypoperfusion in the chronic phase. We have demonstrated the utility of using new magnetic resonance imaging techniques in the evaluation of the pathophysiology of stroke-like lesions. The increased utilization of oxygen in an acute lesion is a novel finding in our study, which might play a role in the oxidative stress. (c) 2012 Elsevier B.V. All rights reserved.

语种英语
所属项目编号30870864 ; 81201154
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS记录号WOS:000311132700030
Citation statistics
Cited Times:11[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57904
Collection北京大学第一临床医学院_神经内科
作者单位1.China Japan Friendship Hosp, Dept Radiol, Beijing 100029, Peoples R China
2.Peking Univ First Hosp, Dept Neurol, Beijing 100034, Peoples R China
3.Peking Univ First Hosp, Dept Radiol, Beijing 100034, Peoples R China
4.Peking Univ, Adv Acad Interdisciplinary Sci, Beijing 100083, Peoples R China
Recommended Citation
GB/T 7714
Wang, Zhaoxia,Xiao, Jiangxi,Xie, Sheng,et al. MR evaluation of cerebral oxygen metabolism and blood flow in stroke-like episodes of MELAS[J]. JOURNAL OF THE NEUROLOGICAL SCIENCES,2012,323(1-2):173-177.
APA Wang, Zhaoxia.,Xiao, Jiangxi.,Xie, Sheng.,Zhao, Danhua.,Liu, Xiwei.,...&Huang, Yining.(2012).MR evaluation of cerebral oxygen metabolism and blood flow in stroke-like episodes of MELAS.JOURNAL OF THE NEUROLOGICAL SCIENCES,323(1-2),173-177.
MLA Wang, Zhaoxia,et al."MR evaluation of cerebral oxygen metabolism and blood flow in stroke-like episodes of MELAS".JOURNAL OF THE NEUROLOGICAL SCIENCES 323.1-2(2012):173-177.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
谷歌学术
谷歌学术Similar articles in
[Wang, Zhaoxia]'s Articles
[Xiao, Jiangxi]'s Articles
[Xie, Sheng]'s Articles
百度学术
百度学术Similar articles in
[Wang, Zhaoxia]'s Articles
[Xiao, Jiangxi]'s Articles
[Xie, Sheng]'s Articles
必应学术
必应学术Similar articles in
[Wang, Zhaoxia]'s Articles
[Xiao, Jiangxi]'s Articles
[Xie, Sheng]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.