IR@PKUHSC  > 北京大学第一临床医学院  > 医学影像科
学科主题临床医学
MR evaluation of cerebral oxygen metabolism and blood flow in stroke-like episodes of MELAS
Wang, Zhaoxia2; Xiao, Jiangxi3; Xie, Sheng1; Zhao, Danhua2; Liu, Xiwei1; Zhang, Jue4; Yuan, Yun2; Huang, Yining2
关键词Magnetic Resonance Imaging Mitochondrial Encephalomyopathy Oxygen Extraction Fraction Lactic Acidosis Cerebral Blood Flow And Stroke-like Pisodes
刊名JOURNAL OF THE NEUROLOGICAL SCIENCES
2012-12-15
DOI10.1016/j.jns.2012.09.011
323期:1-2页:173-177
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Clinical Neurology ; Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]MITOCHONDRIAL MYOPATHY ; LACTIC-ACIDOSIS ; GLUCOSE-METABOLISM ; ENCEPHALOPATHY ; PERFUSION ; MUTATION
英文摘要

Metabolic information is essential in the investigation of the pathophysiology of stroke-like episodes in patients with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS). Here, we used magnetic resonance imaging to evaluate the dynamic metabolic changes before and after a stroke-like episode in two patients with MELAS caused by the mitochondrial DNA mutation A3243G. We performed functional magnetic resonance imaging, including arterial spin labeling and oxygen extraction fraction imaging, and generated cerebral blood flow and oxygen extraction fraction maps. We recruited eight healthy volunteers to define the normal range of the oxygen extraction fraction. We detected a heterogeneous reduction in the oxygen extraction fraction in the brain in the interictal period as well as at the onset of a stroke-like attack. However, the oxygen extraction fraction in the stroke-like lesions normalized in the acute stage. The stroke-like lesions showed consistent hyperperfusion in the acute phase but hypoperfusion in the chronic phase. We have demonstrated the utility of using new magnetic resonance imaging techniques in the evaluation of the pathophysiology of stroke-like lesions. The increased utilization of oxygen in an acute lesion is a novel finding in our study, which might play a role in the oxidative stress. (c) 2012 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000311132700030
项目编号30870864 ; 81201154
资助机构National Natural Science Foundation of China
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57904
专题北京大学第一临床医学院_医学影像科
北京大学第一临床医学院_神经内科
作者单位1.China Japan Friendship Hosp, Dept Radiol, Beijing 100029, Peoples R China
2.Peking Univ First Hosp, Dept Neurol, Beijing 100034, Peoples R China
3.Peking Univ First Hosp, Dept Radiol, Beijing 100034, Peoples R China
4.Peking Univ, Adv Acad Interdisciplinary Sci, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Wang, Zhaoxia,Xiao, Jiangxi,Xie, Sheng,et al. MR evaluation of cerebral oxygen metabolism and blood flow in stroke-like episodes of MELAS[J]. JOURNAL OF THE NEUROLOGICAL SCIENCES,2012,323(1-2):173-177.
APA Wang, Zhaoxia.,Xiao, Jiangxi.,Xie, Sheng.,Zhao, Danhua.,Liu, Xiwei.,...&Huang, Yining.(2012).MR evaluation of cerebral oxygen metabolism and blood flow in stroke-like episodes of MELAS.JOURNAL OF THE NEUROLOGICAL SCIENCES,323(1-2),173-177.
MLA Wang, Zhaoxia,et al."MR evaluation of cerebral oxygen metabolism and blood flow in stroke-like episodes of MELAS".JOURNAL OF THE NEUROLOGICAL SCIENCES 323.1-2(2012):173-177.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wang, Zhaoxia]的文章
[Xiao, Jiangxi]的文章
[Xie, Sheng]的文章
百度学术
百度学术中相似的文章
[Wang, Zhaoxia]的文章
[Xiao, Jiangxi]的文章
[Xie, Sheng]的文章
必应学术
必应学术中相似的文章
[Wang, Zhaoxia]的文章
[Xiao, Jiangxi]的文章
[Xie, Sheng]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。