IR@PKUHSC  > 北京大学口腔医学院  > 口腔颌面外科
学科主题口腔医学
Polyetheretherketone/nano-fluorohydroxyapatite composite with antimicrobial activity and osseointegration properties
Wang, Lixin1; He, Shu2,4; Wu, Xiaomian3,4; Liang, Shanshan5; Mu, Zhonglin5; Wei, Jie6; Deng, Feng3; Deng, Yi4; Wei, Shicheng2,3,4
关键词Polyetheretherketone Fluorohydroxyapatite Antimicrobial Bioactivity Osseointegration Implant
刊名BIOMATERIALS
2014-08-01
DOI10.1016/j.biomaterials.2014.04.085
35期:25页:6758-6775
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]Engineering ; Materials Science
关键词[WOS]FLUORIDATED HYDROXYAPATITE COATINGS ; IN-VIVO BIOCOMPATIBILITY ; OSTEOBLAST-LIKE CELLS ; OSTEOGENIC DIFFERENTIATION ; SURFACE-ROUGHNESS ; TITANIUM SURFACES ; BIOFILM FORMATION ; DENTAL IMPLANTS ; VITRO BEHAVIOR ; BONE INGROWTH
英文摘要

Lack of antibacterial activity and binding ability to natural bone tissue has significantly limited polyetheretherketone (PEEK) for many challenging dental implant applications. Here, we have developed a polyetheretherketone/nano-fluorohydroxyapatite (PEEK/nano-FHA) biocomposite with enhanced antibacterial activity and osseointegration through blending method. Smooth and rough surfaces of PEEK/nano-FHA biocomposites were also prepared. Our results showed that in vitro initial cell adhesion and proliferation on the nano-FHA reinforced PEEK composite were improved. In addition, higher alkaline phosphatase activity and cell mineralization were also detected in cells cultured on PEEK/nano-FHA biocomposites, especially for rough PEEK/nano-FHA surfaces. More importantly, the as-prepared PEEK/nano-FHA biocomposite could effectively prevent the proliferation and biofilm formation of bacterial. For in vivo test, the newly formed bone volume of PEEK/nano-FHA group was higher than that of bare PEEK group based on 3D microcomputed tomography and 2D histomorphometric analysis. These reports demonstrate that the developed PEEK/nano-FHA biocomposite has increased biocompatibility and antibacterial activity in vitro, and promoted osseointegration in vivo, which suggests that it holds potential to be applied as dental implant material in dental tissue engineering applications. (C) 2014 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000338386800010
引用统计
被引频次:59[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57910
专题北京大学口腔医学院_口腔颌面外科
北京大学第三临床医学院_妇产科
作者单位1.Hainan Med Coll, Affiliated Hosp, Hainan 571199, Peoples R China
2.Capital Med Univ, Beijing Shijitan Hosp, Dept Stomatol, Beijing 100038, Peoples R China
3.Peking Univ, Sch & Hosp Stomatol, Lab Interdisciplinary Studies, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China
4.Chongqing Med Univ, Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing 401147, Peoples R China
5.Peking Univ, Acad Adv Interdisciplinary Studies, Ctr Biomed Mat & Tissue Engn, Beijing 100871, Peoples R China
6.E China Univ Sci & Technol, Minist Educ, Engn Res Ctr Biomed Mat, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China
推荐引用方式
GB/T 7714
Wang, Lixin,He, Shu,Wu, Xiaomian,et al. Polyetheretherketone/nano-fluorohydroxyapatite composite with antimicrobial activity and osseointegration properties[J]. BIOMATERIALS,2014,35(25):6758-6775.
APA Wang, Lixin.,He, Shu.,Wu, Xiaomian.,Liang, Shanshan.,Mu, Zhonglin.,...&Wei, Shicheng.(2014).Polyetheretherketone/nano-fluorohydroxyapatite composite with antimicrobial activity and osseointegration properties.BIOMATERIALS,35(25),6758-6775.
MLA Wang, Lixin,et al."Polyetheretherketone/nano-fluorohydroxyapatite composite with antimicrobial activity and osseointegration properties".BIOMATERIALS 35.25(2014):6758-6775.
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