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In vitro antibacterial activity of DX-619, a novel Des-F (6)-quinolone against clinical isolates in China
Xiao, Yonghong; Li, Yun; Liu, Jian; Zhong, Wei; Yang, Weiwei
关键词Antimicrobials Dx-619 Bactericidal Mic Mbc
刊名JOURNAL OF CHEMOTHERAPY
2007-12-01
19期:6页:632-642
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Infectious Diseases ; Pathology ; Pharmacology & Pharmacy
研究领域[WOS]Oncology ; Infectious Diseases ; Pathology ; Pharmacology & Pharmacy
关键词[WOS]DES-FLUORO(6) QUINOLONE ; AGENTS
英文摘要

The aim of the study was to investigate in vitro antibacterial activity and bactericidal effect of DX-619 and other nine comparators against 1,101 recently collected clinical bacterial isolates in China. The minimum inhibitory concentrations (MICs) of antimicrobials were determined by a CLSI recommended standard agar dilution method and the minimum bactericidal concentrations (MBCs) were examined by the broth dilution method. Time-kill curves against representative isolates of Staphylococcus aureus, enterococci, and Klebsiellia pneumoniae were also conducted.

DX-619 exhibited excellent antibacterial activity against 1,101 clinical isolates, especially to multi-drug resistant Gram-positive cocci. The MIC(90)s of DX-619 were <= 0.016 and 0.125 mg/L against methicillin-sensitive and -resistant S. aureus, 0.062 and 0.125 mg/L against methicillin-sensitive and -resistant S. epidermidis, respectively, which were 8-512 and 64-128 fold lower than those of comparative fluoroquinolones. The MIC(90)s of DX-619 for penicillin-sensitive and -non-sensitive Streptococcus pneumoniae, Enterococcus faecalis and Enterococcus faecium were 0.016, 0.062, 0.25 and 0.5 mg/L, respectively. The MIC(90)s of DX-619 against Enterobacteriaceae (except for Escherichia coli) and glucose-nonfermenting bacilli were <= 4 mg/L, which were comparable to other comparators. MBCs and time-kill curves showed that DX-619 was a potent bactericidal agent. There was no significant inoculum effect on MICs. But the activities of DX-619 against S. aureus, K. pneumoniae and Pseudomonas aeruginosa were decreased by acidic pH and human serum. DX-619 was a potent antibacterial compound against multi-drug resistant bacteria including Gram-positive cocci, such as S. aureus and enterococci, which may warrant further exploration.

语种英语
WOS记录号WOS:000252617000003
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被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57914
专题北京大学第一临床医学院_临床药理研究所
作者单位Peking Univ, Hosp 1, Inst Clin Pharmacol, Beijing 100083, Peoples R China
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GB/T 7714
Xiao, Yonghong,Li, Yun,Liu, Jian,et al. In vitro antibacterial activity of DX-619, a novel Des-F (6)-quinolone against clinical isolates in China[J]. JOURNAL OF CHEMOTHERAPY,2007,19(6):632-642.
APA Xiao, Yonghong,Li, Yun,Liu, Jian,Zhong, Wei,&Yang, Weiwei.(2007).In vitro antibacterial activity of DX-619, a novel Des-F (6)-quinolone against clinical isolates in China.JOURNAL OF CHEMOTHERAPY,19(6),632-642.
MLA Xiao, Yonghong,et al."In vitro antibacterial activity of DX-619, a novel Des-F (6)-quinolone against clinical isolates in China".JOURNAL OF CHEMOTHERAPY 19.6(2007):632-642.
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