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学科主题: 基础医学
题名:
Intermedin/adrenomedullin2: an autocrine/paracrine factor in vascular homeostasis and disease
作者: Ni XianQiang1,2,3; Zhang JinSheng1,2,3; Tang ChaoShu1,2; Qi YongFen1,2,3
关键词: intermedin ; vessel ; homeostasis ; vascular diseases
刊名: SCIENCE CHINA-LIFE SCIENCES
发表日期: 2014-08-01
DOI: 10.1007/s11427-014-4701-7
卷: 57, 期:8, 页:781-789
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Biology
研究领域[WOS]: Life Sciences & Biomedicine - Other Topics
关键词[WOS]: SPONTANEOUSLY HYPERTENSIVE-RATS ; GENE-RELATED PEPTIDE ; NITRIC-OXIDE ; BLOOD-PRESSURE ; ADRENOMEDULLIN 2/INTERMEDIN ; ENDOTHELIAL BARRIER ; INTERMEDIN ; RECEPTOR ; CELL ; PATHWAY
英文摘要:

Intermedin (IMD) or adrenomedullin 2 is a novel peptide related to the calcitonin gene-related peptide (CGRP) family. Via calcitonin receptor-like receptor/receptor activity modifying proteins, the common receptor complexes of CGRP, IMD exerts a wide range of biological effects, especially regulation of cardiovascular homeostasis. Proteolytic processing of a larger IMD precursor yields a series of biologically active C-terminal fragments, IMD1-53, IMD1-47 and IMD8-47. IMD and its receptors are present in the cardiovascular system, and IMD is present at low levels in plasma. In the cardiovascular system, IMD has multiple functions such as regulation of blood pressure and cardiac function, pro-angiogenesis, endothelial barrier function protection, anti-oxidative stress, and anti-endoplasmic reticulum stress. IMD participates widely in the pathogenesis of atherosclerosis, hypertension, pulmonary arterial hypertension and vascular calcification. It is a vascular regulatory factor of homeostasis and a vital endogenous protective factor against vascular diseases.

语种: 英语
所属项目编号: 91339203 ; 81270407 ; 81170082
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000340468700006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57916
Appears in Collections:基础医学院_期刊论文

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作者单位: 1.Peking Univ, Sch Basic Med Sci, Lab Cardiovasc Bioact Mol, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100191, Peoples R China
3.Peking Univ, Sch Basic Med Sci, Dept Microbiol & Parasitol, Beijing 100191, Peoples R China

Recommended Citation:
Ni XianQiang,Zhang JinSheng,Tang ChaoShu,et al. Intermedin/adrenomedullin2: an autocrine/paracrine factor in vascular homeostasis and disease[J]. SCIENCE CHINA-LIFE SCIENCES,2014,57(8):781-789.
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