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Further evidence for genetic association of CACNA1C and schizophrenia: New risk loci in a Han Chinese population and a meta-analysis
Zheng, Fanfan1,2; Zhang, Yanling1,2,3; Xie, Wuxiang4; Li, Wenqiang5,6; Jin, Chao7; Mi, Weifeng1,2; Wang, Fang1,2; Ma, Wenbin7; Ma, Cuicui7; Yang, Yongfeng5,6; Du, Bo8; Li, Keqing8; Liu, Chenxing1,2; Wang, Lifang1,2; Lu, Tianlan1,2; Zhang, Hongyan1,2; Wang, Yun9,10; Lu, Lin11; Lv, Luxian5,6; Zhang, Dai1,2,12,13; Yue, Weihua1,2
关键词Cacna1c Rs1006737 Schizophrenia Genetic Association Case-control Study Meta-analysis
刊名SCHIZOPHRENIA RESEARCH
2014
DOI10.1016/j.schres.2013.12.003
152期:1页:105-110
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Psychiatry
研究领域[WOS]Psychiatry
关键词[WOS]GENOME-WIDE ; BIPOLAR DISORDER ; POLYMORPHISM ; SYMPTOMS ; ALLELE ; BIAS ; TWIN
英文摘要

CACNA1C (12p13.3) has been implicated as a susceptibility gene for schizophrenia by several replicated genome wide association studies. While these results have been consistent among studies in European populations, the findings in East Asian populations have varied. To test whether CACNA1C is a risk gene for schizophrenia, we conducted a case-control study in 5897 schizophrenic patients and 6323 healthy control subjects selected from Han Chinese population. Our study replicated the positive associations of rs1006737 (P = 0.0108, OR = 1.16, 95% CI: 1.03-1.29) and rs1024582 (P = 0.0062, OR = 1.18, 95% CI: 1.05-1.33), and identified a novel risk locus, rs2007044 (P = 0.0053, OR = 1.08, 95% CI: 1.02-1.14). A meta-analysis of rs1006737 combining our study and previous studies was conducted in a total of 8222 schizophrenia cases and 24,661 healthy controls. In the meta-analysis, the association between rs1006737 and schizophrenia remained significant (OR = 1.14, 95% CI: 1.07-1.22, P = 0.0001). Stratified analysis showed no heterogeneity between East Asian and European ancestries (chi(2)[1] = 0.07, P = 0.795), and the difference in pooled ORs between ancestries was not significant (Z = 0.25, P = 0.801). Our results provide further support for associations of rs1006737 and rs1024582 with schizophrenia, identify a new risk locus rs2007044 in a Han Chinese population, and further establish CACNA1C as an important susceptibility gene for the disease across world populations. Crown Copyright (C) 2013 Published by Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000329217000015
项目编号2012BAI01B06 ; 81222017 ; 91232305 ; 81071088 ; 81221002
资助机构Science and Technology Project of Ministry of Science and Technology ; National Natural Science Foundation of China
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57918
专题北京大学精神卫生研究所
北京大学医学图书馆_采访编目部
北京大学第一临床医学院_妇产科
北京大学口腔医学院_牙周科
北京大学精神卫生研究所_精神科
北京大学精神卫生研究所_生化室
作者单位1.Peking Univ, Inst Mental Hlth, Beijing 100191, Peoples R China
2.Beijing Aerosp Gen Hosp, Dept Nephrol, Beijing 100076, Peoples R China
3.Jinzhou Kangning Hosp, Jinzhou 121013, Liaoning, Peoples R China
4.Hebei Mental Hlth Ctr, Baoding 071000, Hebei, Peoples R China
5.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing 100191, Peoples R China
6.Capital Med Univ, Affiliated Beijing Anzhen Hosp, Beijing Inst Heart Lung & Blood Vessel Dis, Dept Epidemiol, Beijing 100029, Peoples R China
7.Xinxiang Med Univ, Affiliated Hosp 2, Dept Psychiat, Xinxiang 453002, Henan, Peoples R China
8.Henan Mental Hosp, Henan Key Lab Biol Psychiat, Xinxiang 453002, Henan, Peoples R China
9.Peking Univ, Hlth Sci Ctr, Neurosci Res Inst, Beijing 100191, Peoples R China
10.Peking Univ, Hlth Sci Ctr, Minist Educ & Hlth, Dept Neurobiol,Key Lab Neurosci, Beijing 100191, Peoples R China
11.Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China
12.Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China
13.Peking Univ, Inst Brain Res, PKU IDG McGoven, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Zheng, Fanfan,Zhang, Yanling,Xie, Wuxiang,et al. Further evidence for genetic association of CACNA1C and schizophrenia: New risk loci in a Han Chinese population and a meta-analysis[J]. SCHIZOPHRENIA RESEARCH,2014,152(1):105-110.
APA Zheng, Fanfan.,Zhang, Yanling.,Xie, Wuxiang.,Li, Wenqiang.,Jin, Chao.,...&Yue, Weihua.(2014).Further evidence for genetic association of CACNA1C and schizophrenia: New risk loci in a Han Chinese population and a meta-analysis.SCHIZOPHRENIA RESEARCH,152(1),105-110.
MLA Zheng, Fanfan,et al."Further evidence for genetic association of CACNA1C and schizophrenia: New risk loci in a Han Chinese population and a meta-analysis".SCHIZOPHRENIA RESEARCH 152.1(2014):105-110.
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