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学科主题: 精神卫生
题名:
Further evidence for genetic association of CACNA1C and schizophrenia: New risk loci in a Han Chinese population and a meta-analysis
作者: Zheng, Fanfan1,2; Zhang, Yanling1,2,3; Xie, Wuxiang4; Li, Wenqiang5,6; Jin, Chao7; Mi, Weifeng1,2; Wang, Fang1,2; Ma, Wenbin7; Ma, Cuicui7; Yang, Yongfeng5,6; Du, Bo8; Li, Keqing8; Liu, Chenxing1,2; Wang, Lifang1,2; Lu, Tianlan1,2; Zhang, Hongyan1,2; Wang, Yun9,10; Lu, Lin11; Lv, Luxian5,6; Zhang, Dai1,2,12,13; Yue, Weihua1,2
关键词: CACNA1C ; rs1006737 ; Schizophrenia ; Genetic association ; Case-control study ; Meta-analysis
刊名: SCHIZOPHRENIA RESEARCH
发表日期: 2014
DOI: 10.1016/j.schres.2013.12.003
卷: 152, 期:1, 页:105-110
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Psychiatry
研究领域[WOS]: Psychiatry
关键词[WOS]: GENOME-WIDE ; BIPOLAR DISORDER ; POLYMORPHISM ; SYMPTOMS ; ALLELE ; BIAS ; TWIN
英文摘要:

CACNA1C (12p13.3) has been implicated as a susceptibility gene for schizophrenia by several replicated genome wide association studies. While these results have been consistent among studies in European populations, the findings in East Asian populations have varied. To test whether CACNA1C is a risk gene for schizophrenia, we conducted a case-control study in 5897 schizophrenic patients and 6323 healthy control subjects selected from Han Chinese population. Our study replicated the positive associations of rs1006737 (P = 0.0108, OR = 1.16, 95% CI: 1.03-1.29) and rs1024582 (P = 0.0062, OR = 1.18, 95% CI: 1.05-1.33), and identified a novel risk locus, rs2007044 (P = 0.0053, OR = 1.08, 95% CI: 1.02-1.14). A meta-analysis of rs1006737 combining our study and previous studies was conducted in a total of 8222 schizophrenia cases and 24,661 healthy controls. In the meta-analysis, the association between rs1006737 and schizophrenia remained significant (OR = 1.14, 95% CI: 1.07-1.22, P = 0.0001). Stratified analysis showed no heterogeneity between East Asian and European ancestries (chi(2)[1] = 0.07, P = 0.795), and the difference in pooled ORs between ancestries was not significant (Z = 0.25, P = 0.801). Our results provide further support for associations of rs1006737 and rs1024582 with schizophrenia, identify a new risk locus rs2007044 in a Han Chinese population, and further establish CACNA1C as an important susceptibility gene for the disease across world populations. Crown Copyright (C) 2013 Published by Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 2012BAI01B06 ; 81222017 ; 91232305 ; 81071088 ; 81221002
项目资助者: Science and Technology Project of Ministry of Science and Technology ; National Natural Science Foundation of China
WOS记录号: WOS:000329217000015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57918
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Peking Univ, Inst Mental Hlth, Beijing 100191, Peoples R China
2.Beijing Aerosp Gen Hosp, Dept Nephrol, Beijing 100076, Peoples R China
3.Jinzhou Kangning Hosp, Jinzhou 121013, Liaoning, Peoples R China
4.Hebei Mental Hlth Ctr, Baoding 071000, Hebei, Peoples R China
5.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing 100191, Peoples R China
6.Capital Med Univ, Affiliated Beijing Anzhen Hosp, Beijing Inst Heart Lung & Blood Vessel Dis, Dept Epidemiol, Beijing 100029, Peoples R China
7.Xinxiang Med Univ, Affiliated Hosp 2, Dept Psychiat, Xinxiang 453002, Henan, Peoples R China
8.Henan Mental Hosp, Henan Key Lab Biol Psychiat, Xinxiang 453002, Henan, Peoples R China
9.Peking Univ, Hlth Sci Ctr, Neurosci Res Inst, Beijing 100191, Peoples R China
10.Peking Univ, Hlth Sci Ctr, Minist Educ & Hlth, Dept Neurobiol,Key Lab Neurosci, Beijing 100191, Peoples R China
11.Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China
12.Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China
13.Peking Univ, Inst Brain Res, PKU IDG McGoven, Beijing 100871, Peoples R China

Recommended Citation:
Zheng, Fanfan,Zhang, Yanling,Xie, Wuxiang,et al. Further evidence for genetic association of CACNA1C and schizophrenia: New risk loci in a Han Chinese population and a meta-analysis[J]. SCHIZOPHRENIA RESEARCH,2014,152(1):105-110.
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