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学科主题: 基础医学
题名:
The early progenitors of mouse dendritic cells and plasmacytoid predendritic cells are within the bone marrow hemopoietic precursors expressing Flt3
作者: D′ Amico, A; Wu, L
关键词: dendritic cells ; plasmacytoid predendritic cells ; Flt3 ; bone marrow ; hemopoietic progenitors
刊名: JOURNAL OF EXPERIMENTAL MEDICINE
发表日期: 2003-07-21
DOI: 10.1084/jem.20030107
卷: 198, 期:2, 页:293-303
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology ; Medicine, Research & Experimental
研究领域[WOS]: Immunology ; Research & Experimental Medicine
关键词[WOS]: COLONY-STIMULATING FACTOR ; COMMON MYELOID PROGENITOR ; RECEPTOR TYROSINE KINASE ; IN-VIVO ; IMMATURE APCS ; STEM-CELLS ; LIGAND ; GENERATION ; SURFACE ; MICE
英文摘要:

Flt3 ligand (Flt3L) is a growth factor for hemopoietic progenitors and can promote the expansion of both conventional dendritic cells (DCs) and plasmacytoid predendritic cells (p-preDCs). The cells responding to Flt3L treatment and the precursors for the DCs and p-preDCs had not been fully characterized. We examined different mouse bone marrow (BM) hemopoietic precursor populations for the surface expression of Flt3 and tested them for early DC and p-preDC precursor activity. Most DC precursor activity, other than that given by multipotent hemopoietic stem cells, was within the downstream precursors expressing Flt3. The majority of mouse BM common lymphoid precursors expressed high levels of Flt3 and these were the most efficient precursors of both DCs and p-preDCs. In contrast, only a small proportion of the common myeloid precursors (CMPs) expressed Flt3, but the precursor activity for both DCs and p-preDCs was within this minor Flt3(+) CMP fraction. The granulocyte and macrophage precursors and pro-B cells did not express Flt3 and had no DC or p-preDC precursor activity. These findings demonstrate that the early precursors for all DC subtypes are within the BM Flt3+ precursor populations, regardless of their lymphoid or myeloid lineage orientation.

语种: 英语
WOS记录号: WOS:000184368200011
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57921
Appears in Collections:基础医学院_免疫学系_期刊论文

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作者单位: 1.Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia
2.Peking Univ, Hlth Sci Ctr, Dept Immunol, Beijing 100083, Peoples R China

Recommended Citation:
D&prime,Amico, A,Wu, L. The early progenitors of mouse dendritic cells and plasmacytoid predendritic cells are within the bone marrow hemopoietic precursors expressing Flt3[J]. JOURNAL OF EXPERIMENTAL MEDICINE,2003,198(2):293-303.
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