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学科主题基础医学
The early progenitors of mouse dendritic cells and plasmacytoid predendritic cells are within the bone marrow hemopoietic precursors expressing Flt3
D′ Amico, A; Wu, L
关键词dendritic cells plasmacytoid predendritic cells Flt3 bone marrow hemopoietic progenitors
刊名JOURNAL OF EXPERIMENTAL MEDICINE
2003-07-21
DOI10.1084/jem.20030107
198期:2页:293-303
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology ; Medicine, Research & Experimental
研究领域[WOS]Immunology ; Research & Experimental Medicine
关键词[WOS]COLONY-STIMULATING FACTOR ; COMMON MYELOID PROGENITOR ; RECEPTOR TYROSINE KINASE ; IN-VIVO ; IMMATURE APCS ; STEM-CELLS ; LIGAND ; GENERATION ; SURFACE ; MICE
英文摘要

Flt3 ligand (Flt3L) is a growth factor for hemopoietic progenitors and can promote the expansion of both conventional dendritic cells (DCs) and plasmacytoid predendritic cells (p-preDCs). The cells responding to Flt3L treatment and the precursors for the DCs and p-preDCs had not been fully characterized. We examined different mouse bone marrow (BM) hemopoietic precursor populations for the surface expression of Flt3 and tested them for early DC and p-preDC precursor activity. Most DC precursor activity, other than that given by multipotent hemopoietic stem cells, was within the downstream precursors expressing Flt3. The majority of mouse BM common lymphoid precursors expressed high levels of Flt3 and these were the most efficient precursors of both DCs and p-preDCs. In contrast, only a small proportion of the common myeloid precursors (CMPs) expressed Flt3, but the precursor activity for both DCs and p-preDCs was within this minor Flt3(+) CMP fraction. The granulocyte and macrophage precursors and pro-B cells did not express Flt3 and had no DC or p-preDC precursor activity. These findings demonstrate that the early precursors for all DC subtypes are within the BM Flt3+ precursor populations, regardless of their lymphoid or myeloid lineage orientation.

语种英语
WOS记录号WOS:000184368200011
Citation statistics
Cited Times:242[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57921
Collection北京大学基础医学院_免疫学系
作者单位1.Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia
2.Peking Univ, Hlth Sci Ctr, Dept Immunol, Beijing 100083, Peoples R China
Recommended Citation
GB/T 7714
D&prime,Amico, A,Wu, L. The early progenitors of mouse dendritic cells and plasmacytoid predendritic cells are within the bone marrow hemopoietic precursors expressing Flt3[J]. JOURNAL OF EXPERIMENTAL MEDICINE,2003,198(2):293-303.
APA D&prime,Amico, A,&Wu, L.(2003).The early progenitors of mouse dendritic cells and plasmacytoid predendritic cells are within the bone marrow hemopoietic precursors expressing Flt3.JOURNAL OF EXPERIMENTAL MEDICINE,198(2),293-303.
MLA D&prime,et al."The early progenitors of mouse dendritic cells and plasmacytoid predendritic cells are within the bone marrow hemopoietic precursors expressing Flt3".JOURNAL OF EXPERIMENTAL MEDICINE 198.2(2003):293-303.
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