|A systematic review for the antidepressant effects of sleep deprivation with repetitive transcranial magnetic stimulation|
|Tang, Qing1,2; Li, Guangming3; Wang, Anguo4; Liu, Tao5; Feng, Shenggang6; Guo, Zhiwei1,2; Chen, Huaping1,2; He, Bin1,2; McClure, Morgan A.1,2; Ou, Jun1,2; Xing, Guoqiang7; Mu, Qiwen1,2,8|
|关键词||Depression Sleep Deprivation Repetitive Transcranial Magnetic Stimulation (Rtms) Systematic Review|
|WOS标题词||Science & Technology|
|关键词[WOS]||TREATMENT-RESISTANT DEPRESSION ; DORSOLATERAL PREFRONTAL CORTEX ; TREATING MAJOR DEPRESSION ; RTMS TREATMENT ; DOUBLE-BLIND ; RECEPTOR SENSITIVITY ; UNIPOLAR DEPRESSION ; CONTROLLED-TRIALS ; RANDOMIZED-TRIAL ; HF-RTMS|
Background: Sleep deprivation (SD) and repetitive transcranial magnetic stimulation (rTMS) have been commonly used to treat depression. Recent studies suggest that co-therapy with rTMS and SD may produce better therapeutic effects than either therapy alone. Therefore, this study was to review the current findings to determine if rTMS can augment the therapeutic effects of SD on depression.
Methods: Embase, JSTOR, Medline, PubMed, ScienceDirect, and the Cochrane Central Register of Controlled Trials were searched for clinical studies published between January 1985 and March 2015 using the search term "rTMS/repetitive transcranial magnetic stimulation AND sleep deprivation AND depress*". Only randomized and sham-controlled trials (RCTs) involving the combined use of rTMS and SD in depression patients were included in this systematic review. The scores of the Hamilton Rating Scale for Depression were extracted as primary outcome measures.
Results: Three RCTs with 72 patients that met the inclusion criteria were included for the systematic review. One of the trials reported skewed data and was described alone. The other two studies, which involved 30 patients in the experimental group (SD + active rTMS) and 22 patients in the control group (SD + sham rTMS), reported normally distributed data. The primary outcome measures showed different results among the three publications: two of which showed great difference between the experimental and the control subjects, and the other one showed non-significant antidepressant effect of rTMS on SD. In addition, two of the included studies reported secondary outcome measures with Clinical Global Impression Rating Scale and a self-reported well-being scale which presented good improvement for the depressive patients in the experiment group when compared with the control. The follow-up assessments in two studies indicated maintained results with the immediate measurements.
Conclusions: From this study, an overview of the publications concerning the combined use of rTMS and SD is presented, which provides a direction for future research of therapies for depression. More studies are needed to confirm whether there is an augmentative antidepressant effect of rTMS on SD.
|项目编号||81271559 ; 20155100056 ; 2011HH0017 ; 110616|
|资助机构||National Natural Science Foundation of China (NSFC) ; State Administration of Foreign Experts Affairs, the P.R. of China ; Basic Program Funded by Science & ; Technology Department of Sichuan Province ; Scientific Research Project of Sichuan Health Department|
|作者单位||1.North Sichuan Med Univ, Nanchong Cent Hosp, Dept Radiol, Nanchong 637000, Sichuan, Peoples R China|
2.Peking Univ, Hosp 3, Beijing 100080, Peoples R China
3.North Sichuan Med Univ, Nanchong Cent Hosp, Imaging Inst Rehabil & Dev Brain Funct, Nanchong 637000, Sichuan, Peoples R China
4.North Sichuan Med Univ, Nanchong Cent Hosp, Dept Oncol, Nanchong 637000, Sichuan, Peoples R China
5.North Sichuan Med Univ, Nanchong Cent Hosp, Dept Urol Surg, Nanchong 637000, Sichuan, Peoples R China
6.North Sichuan Med Univ, Nanchong Cent Hosp, Dept Cardiol, Nanchong 637000, Sichuan, Peoples R China
7.North Sichuan Med Univ, Nanchong Cent Hosp, Dept Nephrol, Nanchong 637000, Sichuan, Peoples R China
8.Johns Hopkins Univ, Lotus Biotech Com LLC, MCC, Rockville, MD 20850 USA
|Tang, Qing,Li, Guangming,Wang, Anguo,et al. A systematic review for the antidepressant effects of sleep deprivation with repetitive transcranial magnetic stimulation[J]. BMC PSYCHIATRY,2015,15.|
|APA||Tang, Qing.,Li, Guangming.,Wang, Anguo.,Liu, Tao.,Feng, Shenggang.,...&Mu, Qiwen.(2015).A systematic review for the antidepressant effects of sleep deprivation with repetitive transcranial magnetic stimulation.BMC PSYCHIATRY,15.|
|MLA||Tang, Qing,et al."A systematic review for the antidepressant effects of sleep deprivation with repetitive transcranial magnetic stimulation".BMC PSYCHIATRY 15(2015).|