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学科主题临床医学
LGR5 is a promising biornarker for patients with stage I and II gastric cancer
Bu, Zhaode1; Zheng, Zhixue1; Zhang, Lianhai1; Li, Ziyu1; Sun, Yu2; Dong, Bin2; Wu, Aiwen1; Wu, Xiaojiang1; Wang, Xiaohong3; Cheng, Xiaojing3; Xing, Xiaofang3; Li, Yingai4; Du, Hong4; Ji, Jiafu1
关键词Leucine-rich Repeat-containing g Protein-coupled Receptor 5 (Lgr5) Gastric Cancer Cancer Stem Cell Biomarker Prognosis
刊名CHINESE JOURNAL OF CANCER RESEARCH
2013-02-01
DOI10.3978/j.issn.1000-9604.2013.01.07
25期:1页:79-89
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]PROTEIN-COUPLED RECEPTOR ; STEM-CELL MARKER ; BARRETTS-ESOPHAGUS ; IDENTIFICATION ; COLON ; OVEREXPRESSION ; POPULATION ; EXPRESSION ; GPR49 ; DEFINES
英文摘要

Objective: To investigate Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5) expressions in gastric cancer and to evaluate its clinical significance.

Methods: LGR5 expression was assessed by immunohistochemistry in 257 gastric cancer patients after surgery. The relationships between LGR5 expression and clinicopathological features and patients prognosis were statistically analyzed.

Results: The expression of LGR5 was significantly higher in gastric cancers as a cancer stem cell marker than in adjacent normal tissues (P<0.001), and more frequently in patients with intestinal type, well-moderate differentiation and stage I and II (P<0.05). Although we found gastric cancer patients with LGR5 positive expression. had a poorer prognosis, it didn′t meet statistical significance (P>0.05). LGR5 negative expression was significantly related to the favorable overall survival in stage I and II gastric cancer patients (P<0.05). Furthermore, patients with high LGR5 expression. tended to be more likely to get progression and have poorer progress-free survival (P<0.05). Muldvariate Cox regression analysis revealed that LGR5 expression was an independent factor of overall survival for the patients with stage I and II gastric cancer (P<0.05).

Conclusions: Our results show that LGR5 may play an important role in tumorigenesis and progression and would be a powerful marker to predict the prognosis of patients with stage I and II gastric cancer.

语种英语
WOS记录号WOS:000314793300012
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57934
专题北京大学临床肿瘤学院_胃肠肿瘤中心
北京大学临床肿瘤学院_胃肠肿瘤中心一病区
北京大学临床肿瘤学院_中心实验室
北京大学临床肿瘤学院_标本库
作者单位1.Peking Univ, Canc Hosp & Inst, Dept Gastrointestinal Surg, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
2.Peking Univ, Dept Pathol, Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
3.Peking Univ, Canc Hosp & Inst, Clin Gastr Canc Res Lab, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
4.Peking Univ, Tissue Bank, Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
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GB/T 7714
Bu, Zhaode,Zheng, Zhixue,Zhang, Lianhai,et al. LGR5 is a promising biornarker for patients with stage I and II gastric cancer[J]. CHINESE JOURNAL OF CANCER RESEARCH,2013,25(1):79-89.
APA Bu, Zhaode.,Zheng, Zhixue.,Zhang, Lianhai.,Li, Ziyu.,Sun, Yu.,...&Ji, Jiafu.(2013).LGR5 is a promising biornarker for patients with stage I and II gastric cancer.CHINESE JOURNAL OF CANCER RESEARCH,25(1),79-89.
MLA Bu, Zhaode,et al."LGR5 is a promising biornarker for patients with stage I and II gastric cancer".CHINESE JOURNAL OF CANCER RESEARCH 25.1(2013):79-89.
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