|Dietary acid load, insulin sensitivity and risk of type 2 diabetes in community-dwelling older men|
|Xu, Hong1,2,3; Jia, Ting1,2; Huang, Xiaoyan1,2,4; Riserus, Ulf5; Cederholm, Tommy5; Arnlov, Johan6,7; Sjogren, Per5; Lindholm, Bengt1,2; Carrero, Juan-Jesus1,2,8|
|关键词||Diabetes Incidence Dietary Acid Load Insulin Resistance Insulin Sensitivity Kidney Function|
|WOS标题词||Science & Technology|
|类目[WOS]||Endocrinology & Metabolism|
|研究领域[WOS]||Endocrinology & Metabolism|
|关键词[WOS]||NUTRITION EXAMINATION SURVEY ; CHRONIC KIDNEY-DISEASE ; METABOLIC-ACIDOSIS ; SERUM BICARBONATE ; SKELETAL-MUSCLE ; NATIONAL-HEALTH ; ENERGY-INTAKE ; LIFE-STYLE ; RESISTANCE ; SECRETION|
Aims/hypothesis We tested the hypothesis that dietary acid load may increase the risk of type 2 diabetes, and studied the association between acid load and insulin sensitivity as a possible mechanism involved.
Methods An observational survey with prospective follow-up including 911 non-diabetic Swedish men aged 70-71 years was carried out. The gold standard euglycaemic-hyperinsulinaemic clamp technique and the OGTT were used to determine insulin sensitivity and beta cell function, respectively. Diabetes incidence was assessed during 18 years of follow-up. Renal function was estimated from serum cystatin C concentrations. Dietary acid load was calculated as potential renal acid load (PRAL) and net endogenous acid production (NEAP) algorithms from 7 day food records. Adequate dietary reporters were identified by Goldberg cut-offs.
Results PRAL and NEAP were not associated with insulin sensitivity or beta cell function. Underlying kidney function or consideration of dietary adequate reporters did not modify these null findings. During follow-up, 115 new cases of diabetes were validated. Neither PRAL nor NEAP was associated with diabetes incidence.
Conclusios/interpretation Our results do not support the hypothesis that dietary acid load influences insulin sensitivity, beta cell function or diabetes risk. Interventional studies modifying acid-base dietary intake are needed to further elucidate a possible role of acid load in the development of type 2 diabetes.
|资助机构||Swedish Research Council ; Westman Foundation ; Baxter Healthcare Corporation|
|作者单位||1.Uppsala Univ, Dept Publ Hlth & Caring Sci, Uppsala, Sweden|
2.Dalarna Univ, Sch Hlth & Social Studies, Falun, Sweden
3.Karolinska Inst, Ctr Mol Med, Stockholm, Sweden
4.Karolinska Univ Hosp K56, Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Renal Med, S-14186 Stockholm, Sweden
5.Karolinska Univ Hosp K56, Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Baxter Novum, S-14186 Stockholm, Sweden
6.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Nephrol, Beijing 100730, Peoples R China
7.Peking Univ, Shenzhen Hosp, Div Nephrol, Shenzhen, Peoples R China
8.Uppsala Univ, Dept Publ Hlth & Caring Sci, Sect Geriatr, Uppsala, Sweden
|Xu, Hong,Jia, Ting,Huang, Xiaoyan,et al. Dietary acid load, insulin sensitivity and risk of type 2 diabetes in community-dwelling older men[J]. DIABETOLOGIA,2014,57(8):1561-1568.|
|APA||Xu, Hong.,Jia, Ting.,Huang, Xiaoyan.,Riserus, Ulf.,Cederholm, Tommy.,...&Carrero, Juan-Jesus.(2014).Dietary acid load, insulin sensitivity and risk of type 2 diabetes in community-dwelling older men.DIABETOLOGIA,57(8),1561-1568.|
|MLA||Xu, Hong,et al."Dietary acid load, insulin sensitivity and risk of type 2 diabetes in community-dwelling older men".DIABETOLOGIA 57.8(2014):1561-1568.|