IR@PKUHSC  > 北京大学深圳医院  > 肾内科
学科主题临床医学
Dietary acid load, insulin sensitivity and risk of type 2 diabetes in community-dwelling older men
Xu, Hong1,2,3; Jia, Ting1,2; Huang, Xiaoyan1,2,4; Riserus, Ulf5; Cederholm, Tommy5; Arnlov, Johan6,7; Sjogren, Per5; Lindholm, Bengt1,2; Carrero, Juan-Jesus1,2,8
关键词Diabetes Incidence Dietary Acid Load Insulin Resistance Insulin Sensitivity Kidney Function
刊名DIABETOLOGIA
2014-08-01
DOI10.1007/s00125-014-3275-z
57期:8页:1561-1568
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Endocrinology & Metabolism
研究领域[WOS]Endocrinology & Metabolism
关键词[WOS]NUTRITION EXAMINATION SURVEY ; CHRONIC KIDNEY-DISEASE ; METABOLIC-ACIDOSIS ; SERUM BICARBONATE ; SKELETAL-MUSCLE ; NATIONAL-HEALTH ; ENERGY-INTAKE ; LIFE-STYLE ; RESISTANCE ; SECRETION
英文摘要

Aims/hypothesis We tested the hypothesis that dietary acid load may increase the risk of type 2 diabetes, and studied the association between acid load and insulin sensitivity as a possible mechanism involved.

Methods An observational survey with prospective follow-up including 911 non-diabetic Swedish men aged 70-71 years was carried out. The gold standard euglycaemic-hyperinsulinaemic clamp technique and the OGTT were used to determine insulin sensitivity and beta cell function, respectively. Diabetes incidence was assessed during 18 years of follow-up. Renal function was estimated from serum cystatin C concentrations. Dietary acid load was calculated as potential renal acid load (PRAL) and net endogenous acid production (NEAP) algorithms from 7 day food records. Adequate dietary reporters were identified by Goldberg cut-offs.

Results PRAL and NEAP were not associated with insulin sensitivity or beta cell function. Underlying kidney function or consideration of dietary adequate reporters did not modify these null findings. During follow-up, 115 new cases of diabetes were validated. Neither PRAL nor NEAP was associated with diabetes incidence.

Conclusios/interpretation Our results do not support the hypothesis that dietary acid load influences insulin sensitivity, beta cell function or diabetes risk. Interventional studies modifying acid-base dietary intake are needed to further elucidate a possible role of acid load in the development of type 2 diabetes.

语种英语
WOS记录号WOS:000338997500006
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57935
专题北京大学深圳医院_肾内科
作者单位1.Uppsala Univ, Dept Publ Hlth & Caring Sci, Uppsala, Sweden
2.Dalarna Univ, Sch Hlth & Social Studies, Falun, Sweden
3.Karolinska Inst, Ctr Mol Med, Stockholm, Sweden
4.Karolinska Univ Hosp K56, Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Renal Med, S-14186 Stockholm, Sweden
5.Karolinska Univ Hosp K56, Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Baxter Novum, S-14186 Stockholm, Sweden
6.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Nephrol, Beijing 100730, Peoples R China
7.Peking Univ, Shenzhen Hosp, Div Nephrol, Shenzhen, Peoples R China
8.Uppsala Univ, Dept Publ Hlth & Caring Sci, Sect Geriatr, Uppsala, Sweden
推荐引用方式
GB/T 7714
Xu, Hong,Jia, Ting,Huang, Xiaoyan,et al. Dietary acid load, insulin sensitivity and risk of type 2 diabetes in community-dwelling older men[J]. DIABETOLOGIA,2014,57(8):1561-1568.
APA Xu, Hong.,Jia, Ting.,Huang, Xiaoyan.,Riserus, Ulf.,Cederholm, Tommy.,...&Carrero, Juan-Jesus.(2014).Dietary acid load, insulin sensitivity and risk of type 2 diabetes in community-dwelling older men.DIABETOLOGIA,57(8),1561-1568.
MLA Xu, Hong,et al."Dietary acid load, insulin sensitivity and risk of type 2 diabetes in community-dwelling older men".DIABETOLOGIA 57.8(2014):1561-1568.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Xu, Hong]的文章
[Jia, Ting]的文章
[Huang, Xiaoyan]的文章
百度学术
百度学术中相似的文章
[Xu, Hong]的文章
[Jia, Ting]的文章
[Huang, Xiaoyan]的文章
必应学术
必应学术中相似的文章
[Xu, Hong]的文章
[Jia, Ting]的文章
[Huang, Xiaoyan]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。