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学科主题: 临床医学
题名:
A multicentre, randomized, controlled trial of oseltamivir in the treatment of influenza in a high-risk Chinese population
作者: Lin, JT; Yu, XZ; Cui, DJ; Chen, XY; Zhu, JH; Wang, YZ; Wu, XD
关键词: high-risk population ; influenza ; oseltamivir ; randomized controlled trial
刊名: CURRENT MEDICAL RESEARCH AND OPINION
发表日期: 2006
DOI: 10.1185/030079906X820297
卷: 22, 期:1, 页:75-82
收录类别: ISTP ; SCI
文章类型: Proceedings Paper
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal ; Medicine, Research & Experimental
研究领域[WOS]: General & Internal Medicine ; Research & Experimental Medicine
关键词[WOS]: CONGESTIVE-HEART-FAILURE ; IMPACT ; INFECTION ; COMPLICATIONS ; PREVENTION ; PNEUMONIA ; EFFICACY ; ONTARIO ; SAFETY ; VIRUS
英文摘要:

Objective: To evaluate the efficacy and safety of oseltamivir treatment in a population at high risk for influenza.

Research design and methods: This was a randomized, open-label, controlled trial involving Chinese patients with chronic respiratory diseases (chronic bronchitis, obstructive emphysema, bronchial asthma or bronchiectasis) or chronic cardiac disease. Patients showing symptoms of influenza were randomly assigned to receive oral oseltamivir 75 mg twice daily for 5 days (oseltamivir group), or symptomatic treatment (control group) within 48 h after symptom onset.

Main outcome measures: The main outcome measures were duration and severity of illness in influenza-infected patients. Other outcome measures included incidence of complications, antibiotic use, hospitalization and total medical cost.

Results: Of the 118 recruited patients, 56 were identified as influenza-infected through laboratory tests (oseltamivir, N = 27; control, N = 29). Relative to symptomatic treatment, oseltamivir significantly reduced the duration of influenza symptoms by 36.8% (p = 0.0479), and the severity by 43.1% (p = 0.0002). In addition, oseltamivir significantly reduced the duration of fever by 45.2% (p = 0.0051), and the time to return to baseline health status by 5 days (p = 0.0011). The incidence of complications (11% vs. 45%, p = 0.0053) and antibiotic use (37% vs. 69%, p = 0.0167) were also significantly lower in the oseltamivir group compared with the control group. The cost of treating influenza and its complications was comparable between the two groups (p = 0.2462).

Conclusions: Oseltamivir is effective and well tolerated in high-risk patients with chronic respiratory or cardiac diseases. It can reduce the duration and severity of influenza symptoms and decrease the incidence of secondary complications and antibiotic use, without increasing the total medical cost.

语种: 英语
WOS记录号: WOS:000234751400009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57936
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Beijing Univ, Peoples Hosp, Beijing 100871, Peoples R China
2.Tianjin Hosp Thorac Dis, Tianjin, Peoples R China
3.Tianjin 3 Med Ctr, Tianjin, Peoples R China
4.Peking United Med Ctr Hosp, Beijing, Peoples R China
5.China Japan Friendship Hosp, Dept Resp Dis, Beijing 100029, Peoples R China
6.Beijing Univ, Hosp 1, Beijing 100871, Peoples R China

Recommended Citation:
Lin, JT,Yu, XZ,Cui, DJ,et al. A multicentre, randomized, controlled trial of oseltamivir in the treatment of influenza in a high-risk Chinese population[J]. CURRENT MEDICAL RESEARCH AND OPINION,2006,22(1):75-82.
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