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学科主题: 药学
题名:
Microbial transformation of bufotalin by Alternaria alternata AS 3.4578
作者: Xin, Xiu-Lan2,3; Zhan, Li-Bin1; Li, Feng-Yun1; Ma, Xiao-Chi1; Liu, Ke-Xin1; Han, Jian2; Guo, De-An2
关键词: biotransformation ; bufotalin ; bufadienolide ; Alternaria alternata ; cytotoxic activity
刊名: JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
发表日期: 2009
DOI: 10.1080/10286020802413197
卷: 11, 期:1, 页:7-11
收录类别: SCI ; IC
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Plant Sciences ; Chemistry, Applied ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ; Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: CYTOTOXIC BUFADIENOLIDES ; MUCOR-POLYMORPHOSPORUS ; BUFALIN ; CINOBUFAGIN ; CELLS ; DEHYDROGENATION ; RESIBUFOGENIN ; HYDROXYLATION ; 3-OH
英文摘要:

The microbial transformation of a cytotoxic bufadienolide, bufotalin (1), was carried out. Three transformed products from 1 by Alternaria alternata were isolated. Their structures were characterized as 3-keto-bufotalin (2), 12 beta-hydroxyl-bufotalin (3), and 3-keto-12 beta-hydroxyl-bufotalin (4) based on the extensive NMR studies. Among them, 3 and 4 were new compounds with strong in vitro cytotoxic activities against HeLa cells.

语种: 英语
所属项目编号: 30701088
项目资助者: National Natural Science Foundation of China and PHR (IHLB)
WOS记录号: WOS:000263367900002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57937
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Dalian Med Univ, Sch Pharmaceut Sci, Dalian 116027, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
3.Beijing Vocat Coll Elect Sci & Technol, Biotechnol Applicat Ctr, Beijing 100029, Peoples R China

Recommended Citation:
Xin, Xiu-Lan,Zhan, Li-Bin,Li, Feng-Yun,et al. Microbial transformation of bufotalin by Alternaria alternata AS 3.4578[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2009,11(1):7-11.
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