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Microbial transformation of bufotalin by Alternaria alternata AS 3.4578
Xin, Xiu-Lan2,3; Zhan, Li-Bin1; Li, Feng-Yun1; Ma, Xiao-Chi1; Liu, Ke-Xin1; Han, Jian2; Guo, De-An2
关键词Biotransformation Bufotalin Bufadienolide Alternaria Alternata Cytotoxic Activity
刊名JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
2009
DOI10.1080/10286020802413197
11期:1页:7-11
收录类别SCI ; IC
文章类型Article
WOS标题词Science & Technology
类目[WOS]Plant Sciences ; Chemistry, Applied ; Chemistry, Medicinal ; Pharmacology & Pharmacy
资助者National Natural Science Foundation of China and PHR (IHLB) ; National Natural Science Foundation of China and PHR (IHLB)
研究领域[WOS]Plant Sciences ; Chemistry ; Pharmacology & Pharmacy
关键词[WOS]CYTOTOXIC BUFADIENOLIDES ; MUCOR-POLYMORPHOSPORUS ; BUFALIN ; CINOBUFAGIN ; CELLS ; DEHYDROGENATION ; RESIBUFOGENIN ; HYDROXYLATION ; 3-OH
英文摘要

The microbial transformation of a cytotoxic bufadienolide, bufotalin (1), was carried out. Three transformed products from 1 by Alternaria alternata were isolated. Their structures were characterized as 3-keto-bufotalin (2), 12 beta-hydroxyl-bufotalin (3), and 3-keto-12 beta-hydroxyl-bufotalin (4) based on the extensive NMR studies. Among them, 3 and 4 were new compounds with strong in vitro cytotoxic activities against HeLa cells.

语种英语
所属项目编号30701088
资助者National Natural Science Foundation of China and PHR (IHLB) ; National Natural Science Foundation of China and PHR (IHLB)
WOS记录号WOS:000263367900002
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57937
专题北京大学药学院
作者单位1.Dalian Med Univ, Sch Pharmaceut Sci, Dalian 116027, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
3.Beijing Vocat Coll Elect Sci & Technol, Biotechnol Applicat Ctr, Beijing 100029, Peoples R China
推荐引用方式
GB/T 7714
Xin, Xiu-Lan,Zhan, Li-Bin,Li, Feng-Yun,et al. Microbial transformation of bufotalin by Alternaria alternata AS 3.4578[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2009,11(1):7-11.
APA Xin, Xiu-Lan.,Zhan, Li-Bin.,Li, Feng-Yun.,Ma, Xiao-Chi.,Liu, Ke-Xin.,...&Guo, De-An.(2009).Microbial transformation of bufotalin by Alternaria alternata AS 3.4578.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,11(1),7-11.
MLA Xin, Xiu-Lan,et al."Microbial transformation of bufotalin by Alternaria alternata AS 3.4578".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 11.1(2009):7-11.
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