学科主题临床医学
Emerging antivirals for the treatment of hepatitis B
Wang, Xue-Yan1,2; Chen, Hong-Song1,2
关键词Hepatitis b Antiviral Nucleoside Analogue Nucleotide Analogue Non-nucleoside Antivirals
刊名WORLD JOURNAL OF GASTROENTEROLOGY
2014-06-28
DOI10.3748/wjg.v20.i24.7707
20期:24页:7707-7717
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]AMPHIPATHIC DNA POLYMERS ; IMMUNODEFICIENCY-VIRUS TYPE-1 ; LARGE ENVELOPE PROTEIN ; REPLICATION IN-VIVO ; HBV INFECTION ; CLEVUDINE THERAPY ; RNA INTERFERENCE ; NATURAL-HISTORY ; GENE-EXPRESSION ; MOUSE MODEL
英文摘要

Chronic infection with hepatitis B virus (HBV) constitutes a major global public health threat, causing substantial disease burdens such as liver cirrhosis and hepatocellular carcinoma, thus representing high unmet medical needs. Currently available therapies are safe, well tolerated, and highly effective in decreasing viremia and improving measured clinical outcomes with low rates of antiviral resistance. However, long-term management remains a clinical challenge, mainly due to the slow kinetics of HBV surface antigen clearance. In this article, we review emerging antivirals directed at novel targets derived from mechanisms of viral cellular entry, viral replication, viral assembly, and the host immune response, leading to preclinical and clinical trials for possible future therapeutic intervention. The recent therapeutic advances in the development of all categories of HBV inhibitors may pave the way for regimens of finite duration that result in long-lasting control of chronic hepatitis B infection. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.

语种英语
WOS记录号WOS:000338520100016
项目编号31340023 ; 91029741 ; 81001072 ; 81171550 ; 2012ZX10002011-006 ; 20130001120075 ; RDB2013-02
资助机构National Natural Science Foundation of China ; National Key Sci-Tech Special Project of China ; Specialized Research Fund for the Doctoral Program of Higher Education ; Peking University People&prime ; s Hospital Research and Development Funds
引用统计
被引频次:23[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57940
专题北京大学第二临床医学院_北京大学肝病研究所
作者单位1.Peking Univ, Peoples Hosp, Inst Hepatol, Beijing 100044, Peoples R China
2.Beijing Key Lab Hepatitis C & Immunotherapy Liver, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Wang, Xue-Yan,Chen, Hong-Song. Emerging antivirals for the treatment of hepatitis B[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2014,20(24):7707-7717.
APA Wang, Xue-Yan,&Chen, Hong-Song.(2014).Emerging antivirals for the treatment of hepatitis B.WORLD JOURNAL OF GASTROENTEROLOGY,20(24),7707-7717.
MLA Wang, Xue-Yan,et al."Emerging antivirals for the treatment of hepatitis B".WORLD JOURNAL OF GASTROENTEROLOGY 20.24(2014):7707-7717.
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