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学科主题: 临床医学
题名:
Emerging antivirals for the treatment of hepatitis B
作者: Wang, Xue-Yan1,2; Chen, Hong-Song1,2
关键词: Hepatitis B ; Antiviral ; Nucleoside analogue ; Nucleotide analogue ; Non-nucleoside antivirals
刊名: WORLD JOURNAL OF GASTROENTEROLOGY
发表日期: 2014-06-28
DOI: 10.3748/wjg.v20.i24.7707
卷: 20, 期:24, 页:7707-7717
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: AMPHIPATHIC DNA POLYMERS ; IMMUNODEFICIENCY-VIRUS TYPE-1 ; LARGE ENVELOPE PROTEIN ; REPLICATION IN-VIVO ; HBV INFECTION ; CLEVUDINE THERAPY ; RNA INTERFERENCE ; NATURAL-HISTORY ; GENE-EXPRESSION ; MOUSE MODEL
英文摘要:

Chronic infection with hepatitis B virus (HBV) constitutes a major global public health threat, causing substantial disease burdens such as liver cirrhosis and hepatocellular carcinoma, thus representing high unmet medical needs. Currently available therapies are safe, well tolerated, and highly effective in decreasing viremia and improving measured clinical outcomes with low rates of antiviral resistance. However, long-term management remains a clinical challenge, mainly due to the slow kinetics of HBV surface antigen clearance. In this article, we review emerging antivirals directed at novel targets derived from mechanisms of viral cellular entry, viral replication, viral assembly, and the host immune response, leading to preclinical and clinical trials for possible future therapeutic intervention. The recent therapeutic advances in the development of all categories of HBV inhibitors may pave the way for regimens of finite duration that result in long-lasting control of chronic hepatitis B infection. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.

语种: 英语
所属项目编号: 31340023 ; 91029741 ; 81001072 ; 81171550 ; 2012ZX10002011-006 ; 20130001120075 ; RDB2013-02
项目资助者: National Natural Science Foundation of China ; National Key Sci-Tech Special Project of China ; Specialized Research Fund for the Doctoral Program of Higher Education ; Peking University People&prime ; s Hospital Research and Development Funds
WOS记录号: WOS:000338520100016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57940
Appears in Collections:北京大学第二临床医学院_北京大学肝病研究所_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Inst Hepatol, Beijing 100044, Peoples R China
2.Beijing Key Lab Hepatitis C & Immunotherapy Liver, Beijing 100044, Peoples R China

Recommended Citation:
Wang, Xue-Yan,Chen, Hong-Song. Emerging antivirals for the treatment of hepatitis B[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2014,20(24):7707-7717.
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