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学科主题: 临床医学
题名:
Regulatory effects of hydrogen sulfide on IL-6, IL-8 and IL-10 levels in the plasma and pulmonary tissue of rats with acute lung injury
作者: Li, Tianshui2; Zhao, Bin2; Wang, Cong2; Wang, Haiying2; Liu, Zhiwei2; Li, Wang3; Jin, Hongfang1,4; Tang, Chaoshu3; Du, Junbao1
关键词: hydrogen sulfide ; acute lung injury ; interleukin ; polymorphonuclear
刊名: EXPERIMENTAL BIOLOGY AND MEDICINE
发表日期: 2008-09-01
DOI: 10.3181/0712-RM-354
卷: 233, 期:9, 页:1081-1087
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
关键词[WOS]: RESPIRATORY-DISTRESS-SYNDROME ; NF-KAPPA-B ; ACUTE-PANCREATITIS ; OLEIC-ACID ; INFLAMMATORY MEDIATORS ; LETHAL ENDOTOXEMIA ; SYNDROME ARDS ; NITRIC-OXIDE ; TNF-ALPHA ; INTERLEUKIN-6
英文摘要:

We examined the possible role of hydrogen sulfide (H(2)S) in the pathogenesis of oleic acid (OA)-induced acute lung injury (ALI) and its regulatory effects on the inflammatory response. Compared to control rats, the OA-treated rats had decreased partial pressure of oxygen in the arterial blood (PaO(2)) levels, an increased pulmonary wet/dry weight (W/D) ratio, increased index of quantitative assessment (IQA) score and increased frequency of polymorphonuclear (PMN) cells in the lung 2, 4 or 6 h after OA injection (0.1 ml/kg, intravenous injection). In addition, significantly increased IL-6, IL-8 and IL-10 levels together with decreased H(2)S levels were observed in the plasma and lung tissue of CA-treated rats compared to controls. Administration of the H(2)S donor sodium hydrosulfide (NaHS, 56 mu mol/L, intraperitoneal injection) into OA-treated rats increased the PaO(2) level, reduced the lung W/D ratio and infiltration of PMN cells, and alleviated the degree of ALI (measured by the IQA score). In addition, NaHS decreased IL-6 and IL-8 levels but increased IL-10 levels in the plasma and lung tissues, suggesting that H(2)S may regulate the inflammatory response during ALI via regulation of IL-6, IL-8 and IL-10. Thus, the down-regulation of endogenous H(2)S production might be involved in the pathogenesis of OA-induced ALI in rats.

语种: 英语
所属项目编号: 30630031 ; 30425010 ; 2006CB503807 ; 7072082 ; 7082095
项目资助者: National Natural Science Foundation of China ; National Science Fund for Distinguished Young Scholars ; Major Basic Research Program of China ; Beijing Natural Science Foundation
WOS记录号: WOS:000258767500004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57944
Appears in Collections:北京大学第一临床医学院_儿科_期刊论文

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作者单位: 1.Peking Univ, First Hosp, Dept Pediat, Beijing 100034, Peoples R China
2.Peking Univ, Fourth Hosp, Dept Emergency, Beijing 100034, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Beijing 100034, Peoples R China
4.Minist Educ China, Kev Lab Mol Cardiol, Beijing, Peoples R China

Recommended Citation:
Li, Tianshui,Zhao, Bin,Wang, Cong,et al. Regulatory effects of hydrogen sulfide on IL-6, IL-8 and IL-10 levels in the plasma and pulmonary tissue of rats with acute lung injury[J]. EXPERIMENTAL BIOLOGY AND MEDICINE,2008,233(9):1081-1087.
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