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Regulatory effects of hydrogen sulfide on IL-6, IL-8 and IL-10 levels in the plasma and pulmonary tissue of rats with acute lung injury
Li, Tianshui2; Zhao, Bin2; Wang, Cong2; Wang, Haiying2; Liu, Zhiwei2; Li, Wang3; Jin, Hongfang1,4; Tang, Chaoshu3; Du, Junbao1
关键词Hydrogen Sulfide Acute Lung Injury Interleukin Polymorphonuclear
刊名EXPERIMENTAL BIOLOGY AND MEDICINE
2008-09-01
DOI10.3181/0712-RM-354
233期:9页:1081-1087
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental
研究领域[WOS]Research & Experimental Medicine
关键词[WOS]RESPIRATORY-DISTRESS-SYNDROME ; NF-KAPPA-B ; ACUTE-PANCREATITIS ; OLEIC-ACID ; INFLAMMATORY MEDIATORS ; LETHAL ENDOTOXEMIA ; SYNDROME ARDS ; NITRIC-OXIDE ; TNF-ALPHA ; INTERLEUKIN-6
英文摘要

We examined the possible role of hydrogen sulfide (H(2)S) in the pathogenesis of oleic acid (OA)-induced acute lung injury (ALI) and its regulatory effects on the inflammatory response. Compared to control rats, the OA-treated rats had decreased partial pressure of oxygen in the arterial blood (PaO(2)) levels, an increased pulmonary wet/dry weight (W/D) ratio, increased index of quantitative assessment (IQA) score and increased frequency of polymorphonuclear (PMN) cells in the lung 2, 4 or 6 h after OA injection (0.1 ml/kg, intravenous injection). In addition, significantly increased IL-6, IL-8 and IL-10 levels together with decreased H(2)S levels were observed in the plasma and lung tissue of CA-treated rats compared to controls. Administration of the H(2)S donor sodium hydrosulfide (NaHS, 56 mu mol/L, intraperitoneal injection) into OA-treated rats increased the PaO(2) level, reduced the lung W/D ratio and infiltration of PMN cells, and alleviated the degree of ALI (measured by the IQA score). In addition, NaHS decreased IL-6 and IL-8 levels but increased IL-10 levels in the plasma and lung tissues, suggesting that H(2)S may regulate the inflammatory response during ALI via regulation of IL-6, IL-8 and IL-10. Thus, the down-regulation of endogenous H(2)S production might be involved in the pathogenesis of OA-induced ALI in rats.

语种英语
WOS记录号WOS:000258767500004
项目编号30630031 ; 30425010 ; 2006CB503807 ; 7072082 ; 7082095
资助机构National Natural Science Foundation of China ; National Science Fund for Distinguished Young Scholars ; Major Basic Research Program of China ; Beijing Natural Science Foundation
引用统计
被引频次:59[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57944
专题北京大学第一临床医学院_儿科
北京大学基础医学院
作者单位1.Peking Univ, First Hosp, Dept Pediat, Beijing 100034, Peoples R China
2.Peking Univ, Fourth Hosp, Dept Emergency, Beijing 100034, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Beijing 100034, Peoples R China
4.Minist Educ China, Kev Lab Mol Cardiol, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Li, Tianshui,Zhao, Bin,Wang, Cong,et al. Regulatory effects of hydrogen sulfide on IL-6, IL-8 and IL-10 levels in the plasma and pulmonary tissue of rats with acute lung injury[J]. EXPERIMENTAL BIOLOGY AND MEDICINE,2008,233(9):1081-1087.
APA Li, Tianshui.,Zhao, Bin.,Wang, Cong.,Wang, Haiying.,Liu, Zhiwei.,...&Du, Junbao.(2008).Regulatory effects of hydrogen sulfide on IL-6, IL-8 and IL-10 levels in the plasma and pulmonary tissue of rats with acute lung injury.EXPERIMENTAL BIOLOGY AND MEDICINE,233(9),1081-1087.
MLA Li, Tianshui,et al."Regulatory effects of hydrogen sulfide on IL-6, IL-8 and IL-10 levels in the plasma and pulmonary tissue of rats with acute lung injury".EXPERIMENTAL BIOLOGY AND MEDICINE 233.9(2008):1081-1087.
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