北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 基础医学院  > 免疫学系  > 期刊论文
学科主题: 基础医学
题名:
Specific CD8(+) T cell responses to HLA-A2 restricted MAGE-A3 p271-279 peptide in hepatocellular carcinoma patients without vaccination
作者: Zhang, Hua-Gang; Chen, Hong-Song; Peng, Ji-Run; Shang, Xiao-Ying; Zhang, Jun; Xing, Qiao; Pang, Xue-Wen; Qin, Li-Ling; Fei, Ran; Mei, Ming-Hui; Leng, Xi-Sheng; Chen, Wei-Feng
关键词: antigens ; peptides ; epitopes ; cytotoxic T cells ; tumor immunity
刊名: CANCER IMMUNOLOGY IMMUNOTHERAPY
发表日期: 2007-12-01
DOI: 10.1007/s00262-007-0338-8
卷: 56, 期:12, 页:1945-1954
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Immunology
研究领域[WOS]: Oncology ; Immunology
关键词[WOS]: MELANOMA PATIENTS ; IMMUNE-RESPONSES ; TUMOR-REGRESSION ; DENDRITIC CELLS ; CANCER-PATIENTS ; CTL RESPONSES ; ANTIGEN ; PROTEIN ; LYMPHOCYTES ; CD4(+)
英文摘要:

The MAGE-A3 protein, one of the promising tumor antigens for immunotherapy, is highly expressed in human hepatocellular carcinoma (HCC). In this study, we estimated the specific CD8(+) T cell immune response to MAGE-A3 p271-279 peptide (M3(271)) in the peripheral blood of HCC patients without antigen vaccination in order to evaluate its immunotherapeutic potential in these patients. After expansion in vitro, the functional IFN-gamma producing M3271 specific CD8(+) T cells were detected in 30.8% (8/26) of HLA-A2(+) MAGE-A3(+) HCC patients. The effector CD8+ T cells could release cytotoxic molecules of granzyme B and perforin after restimulation with natural HLA-A2(+) MAGE-A3(+) HCC cell lines in the samples tested. The functional supertype of HLA-A2 in the presentation of HLA-A*0201 restricted M3(271) peptide has been identified in the Chinese HCC patients of Han ethnicity, that widely expanded the applicability of this tumor peptide vaccine in Chinese HCC patients. Thus, the functionally detectable pre-existence of M3(271)-specific CD8(+) T cells in HCC patients makes M3(271) a potential target for immunotherapy in these patients. The responsive CD8(+) T cells to both NY-ESO-1 and MAGE-A3 antigens provide a rationale for the application of a bivalent vaccine in HCC patients with tumors expressing both antigens.

语种: 英语
WOS记录号: WOS:000249916900008
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57946
Appears in Collections:基础医学院_免疫学系_期刊论文

Files in This Item:
File Name/ File Size Content Type Version Access License
art%3A10.1007%2Fs00262-007-0338-8.pdf(368KB)期刊论文出版稿限制开放 联系获取全文

作者单位: 1.Guangxi Guilin Med Coll, Guilin 541001, Guangxi, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Immunol, Beijing 100083, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Peoples Hosp, Inst Hepatol, Beijing 100044, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Peoples Hosp, Ctr Hepatobiliary Surg, Beijing 100044, Peoples R China

Recommended Citation:
Zhang, Hua-Gang,Chen, Hong-Song,Peng, Ji-Run,et al. Specific CD8(+) T cell responses to HLA-A2 restricted MAGE-A3 p271-279 peptide in hepatocellular carcinoma patients without vaccination[J]. CANCER IMMUNOLOGY IMMUNOTHERAPY,2007,56(12):1945-1954.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhang, Hua-Gang]'s Articles
[Chen, Hong-Song]'s Articles
[Peng, Ji-Run]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhang, Hua-Gang]‘s Articles
[Chen, Hong-Song]‘s Articles
[Peng, Ji-Run]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace