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学科主题基础医学
Specific CD8(+) T cell responses to HLA-A2 restricted MAGE-A3 p271-279 peptide in hepatocellular carcinoma patients without vaccination
Zhang, Hua-Gang; Chen, Hong-Song; Peng, Ji-Run; Shang, Xiao-Ying; Zhang, Jun; Xing, Qiao; Pang, Xue-Wen; Qin, Li-Ling; Fei, Ran; Mei, Ming-Hui; Leng, Xi-Sheng; Chen, Wei-Feng
关键词antigens peptides epitopes cytotoxic T cells tumor immunity
刊名CANCER IMMUNOLOGY IMMUNOTHERAPY
2007-12-01
DOI10.1007/s00262-007-0338-8
56期:12页:1945-1954
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Immunology
研究领域[WOS]Oncology ; Immunology
关键词[WOS]MELANOMA PATIENTS ; IMMUNE-RESPONSES ; TUMOR-REGRESSION ; DENDRITIC CELLS ; CANCER-PATIENTS ; CTL RESPONSES ; ANTIGEN ; PROTEIN ; LYMPHOCYTES ; CD4(+)
英文摘要

The MAGE-A3 protein, one of the promising tumor antigens for immunotherapy, is highly expressed in human hepatocellular carcinoma (HCC). In this study, we estimated the specific CD8(+) T cell immune response to MAGE-A3 p271-279 peptide (M3(271)) in the peripheral blood of HCC patients without antigen vaccination in order to evaluate its immunotherapeutic potential in these patients. After expansion in vitro, the functional IFN-gamma producing M3271 specific CD8(+) T cells were detected in 30.8% (8/26) of HLA-A2(+) MAGE-A3(+) HCC patients. The effector CD8+ T cells could release cytotoxic molecules of granzyme B and perforin after restimulation with natural HLA-A2(+) MAGE-A3(+) HCC cell lines in the samples tested. The functional supertype of HLA-A2 in the presentation of HLA-A*0201 restricted M3(271) peptide has been identified in the Chinese HCC patients of Han ethnicity, that widely expanded the applicability of this tumor peptide vaccine in Chinese HCC patients. Thus, the functionally detectable pre-existence of M3(271)-specific CD8(+) T cells in HCC patients makes M3(271) a potential target for immunotherapy in these patients. The responsive CD8(+) T cells to both NY-ESO-1 and MAGE-A3 antigens provide a rationale for the application of a bivalent vaccine in HCC patients with tumors expressing both antigens.

语种英语
WOS记录号WOS:000249916900008
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被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57946
专题基础医学院_免疫学系
作者单位1.Guangxi Guilin Med Coll, Guilin 541001, Guangxi, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Immunol, Beijing 100083, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Peoples Hosp, Inst Hepatol, Beijing 100044, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Peoples Hosp, Ctr Hepatobiliary Surg, Beijing 100044, Peoples R China
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Zhang, Hua-Gang,Chen, Hong-Song,Peng, Ji-Run,et al. Specific CD8(+) T cell responses to HLA-A2 restricted MAGE-A3 p271-279 peptide in hepatocellular carcinoma patients without vaccination[J]. CANCER IMMUNOLOGY IMMUNOTHERAPY,2007,56(12):1945-1954.
APA Zhang, Hua-Gang.,Chen, Hong-Song.,Peng, Ji-Run.,Shang, Xiao-Ying.,Zhang, Jun.,...&Chen, Wei-Feng.(2007).Specific CD8(+) T cell responses to HLA-A2 restricted MAGE-A3 p271-279 peptide in hepatocellular carcinoma patients without vaccination.CANCER IMMUNOLOGY IMMUNOTHERAPY,56(12),1945-1954.
MLA Zhang, Hua-Gang,et al."Specific CD8(+) T cell responses to HLA-A2 restricted MAGE-A3 p271-279 peptide in hepatocellular carcinoma patients without vaccination".CANCER IMMUNOLOGY IMMUNOTHERAPY 56.12(2007):1945-1954.
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