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学科主题临床医学
Comparison of intravenous ibutilide vs. propafenone for rapid termination of recent onset atrial fibrillation
Zhang, N; Guo, JH; Zhang, HC; Li, XB; Zhang, P; Xn, Y
关键词Ibutilide Propafenone Intravenous Injection Atrial Fibrillation Cardioversion
刊名INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
2005-12-01
DOI10.1111/j.1368-5031.2005.00705.x
59期:12页:1395-1400
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal ; Pharmacology & Pharmacy
研究领域[WOS]General & Internal Medicine ; Pharmacology & Pharmacy
关键词[WOS]CARDIAC-SURGERY ; SINUS RHYTHM ; CONVERSION ; FLUTTER ; AMIODARONE ; EFFICACY ; CARDIOVERSION ; PROCAINAMIDE ; FUMARATE ; SAFETY
英文摘要

This study was to evaluate the efficacy and safety of ibutilide and propafenone given intravenously in converting recent onset atrial fibrillation (AF).

Eighty-two consecutive patients with AF (onset in 2 h to 90 days) were randomly assigned to receive two 10-min infusions, 10 min apart, of either ibutilide (1 mg) or propafenone (70 mg). The treatment was considered successful if sinus rhythm occurred within 90 min after the beginning of infusion.

Ibutilide had a significantly higher rate of cardioversion than propafenone (70.73 vs. 48.78%, p = 0.043). The patients with shorter AF duration or smaller left atrium diameter had a higher success rate. Nonsustained monomorphic ventricular tachycardia was the most serious adverse effect of ibutilide in 9.76% of patients, and hypotension and heart pause were the major serious adverse events in 17.07% of patients treated with propafenone.

Ibutilide is more effective than intravenous propafenone for the cardioversion of recent onset AF, and the adverse effects are rare and transient.

语种英语
WOS记录号WOS:000233408900006
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57947
专题北京大学第二临床医学院
作者单位Peking Univ, Peoples Hosp, Dept Clin Cardiac Electrophysiol, Beijing 100044, Peoples R China
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GB/T 7714
Zhang, N,Guo, JH,Zhang, HC,et al. Comparison of intravenous ibutilide vs. propafenone for rapid termination of recent onset atrial fibrillation[J]. INTERNATIONAL JOURNAL OF CLINICAL PRACTICE,2005,59(12):1395-1400.
APA Zhang, N,Guo, JH,Zhang, HC,Li, XB,Zhang, P,&Xn, Y.(2005).Comparison of intravenous ibutilide vs. propafenone for rapid termination of recent onset atrial fibrillation.INTERNATIONAL JOURNAL OF CLINICAL PRACTICE,59(12),1395-1400.
MLA Zhang, N,et al."Comparison of intravenous ibutilide vs. propafenone for rapid termination of recent onset atrial fibrillation".INTERNATIONAL JOURNAL OF CLINICAL PRACTICE 59.12(2005):1395-1400.
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