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学科主题: 临床医学
题名:
Comparison of intravenous ibutilide vs. propafenone for rapid termination of recent onset atrial fibrillation
作者: Zhang, N; Guo, JH; Zhang, HC; Li, XB; Zhang, P; Xn, Y
关键词: ibutilide ; propafenone ; intravenous injection ; atrial fibrillation ; cardioversion
刊名: INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
发表日期: 2005-12-01
DOI: 10.1111/j.1368-5031.2005.00705.x
卷: 59, 期:12, 页:1395-1400
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal ; Pharmacology & Pharmacy
研究领域[WOS]: General & Internal Medicine ; Pharmacology & Pharmacy
关键词[WOS]: CARDIAC-SURGERY ; SINUS RHYTHM ; CONVERSION ; FLUTTER ; AMIODARONE ; EFFICACY ; CARDIOVERSION ; PROCAINAMIDE ; FUMARATE ; SAFETY
英文摘要:

This study was to evaluate the efficacy and safety of ibutilide and propafenone given intravenously in converting recent onset atrial fibrillation (AF).

Eighty-two consecutive patients with AF (onset in 2 h to 90 days) were randomly assigned to receive two 10-min infusions, 10 min apart, of either ibutilide (1 mg) or propafenone (70 mg). The treatment was considered successful if sinus rhythm occurred within 90 min after the beginning of infusion.

Ibutilide had a significantly higher rate of cardioversion than propafenone (70.73 vs. 48.78%, p = 0.043). The patients with shorter AF duration or smaller left atrium diameter had a higher success rate. Nonsustained monomorphic ventricular tachycardia was the most serious adverse effect of ibutilide in 9.76% of patients, and hypotension and heart pause were the major serious adverse events in 17.07% of patients treated with propafenone.

Ibutilide is more effective than intravenous propafenone for the cardioversion of recent onset AF, and the adverse effects are rare and transient.

语种: 英语
WOS记录号: WOS:000233408900006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57947
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Dept Clin Cardiac Electrophysiol, Beijing 100044, Peoples R China

Recommended Citation:
Zhang, N,Guo, JH,Zhang, HC,et al. Comparison of intravenous ibutilide vs. propafenone for rapid termination of recent onset atrial fibrillation[J]. INTERNATIONAL JOURNAL OF CLINICAL PRACTICE,2005,59(12):1395-1400.
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