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学科主题: 药学
题名:
Protocatechuic acid inhibits neurotoxicity induced by MPTP in vivo
作者: Zhang, Hong-Ning1,2; An, Chun-Na1,2; Zhang, Hui-Nan1,2; Pu, Xiao-Ping1,2
关键词: Parkinson&prime ; s disease ; Protocatechuic acid ; MPTP ; Neuroprotection ; In vivo
刊名: NEUROSCIENCE LETTERS
发表日期: 2010-04-26
DOI: 10.1016/j.neulet.2010.03.016
卷: 474, 期:2, 页:99-103
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: PARKINSONS-DISEASE ; ALPHA-SYNUCLEIN ; MODEL ; ANALOGS ; SYSTEM
英文摘要:

Parkinson′s disease (PD) is characterized by the progressive degeneration of dopaminergic neurons in substantia nigra (SN) with the presence of alpha-synuclein inclusions termed Lewy bodies. The neuroprotective effects of protocatechuic acid (PAc) both in vitro and in vivo have been reported. However, little is known about the effects of PAc on neurotoxicity induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in vivo. In this study, we demonstrated that PAc inhibited the reduction of the latent periods in a rotarod test, and the contents of dopamine (DA) and its metabolites in striatum, and furthermore, it ameliorated the pathology in SN and the decreases in the expression of tyrosine hydroxylase (TH) in SN of C578L/6J mice induced by MPTP. Taken together, our results indicate for the first time that PAc has neuroprotective effects on MPTP treated C57BL/6J mice and may be useful in clinical treatment of PD. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
所属项目编号: 2004CB518902
项目资助者: National Program for Key Basic Research Projects of China
WOS记录号: WOS:000277534800008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57948
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, Dept Mol & Cellular Pharmacol, Beijing 100191, Peoples R China
2.Peking Univ, State Key Lab Nat & Bionrimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Zhang, Hong-Ning,An, Chun-Na,Zhang, Hui-Nan,et al. Protocatechuic acid inhibits neurotoxicity induced by MPTP in vivo[J]. NEUROSCIENCE LETTERS,2010,474(2):99-103.
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