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Protocatechuic acid inhibits neurotoxicity induced by MPTP in vivo
Zhang, Hong-Ning1,2; An, Chun-Na1,2; Zhang, Hui-Nan1,2; Pu, Xiao-Ping1,2
关键词Parkinson&Prime s Disease Protocatechuic Acid Mptp Neuroprotection In Vivo
刊名NEUROSCIENCE LETTERS
2010-04-26
DOI10.1016/j.neulet.2010.03.016
474期:2页:99-103
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
资助者National Program for Key Basic Research Projects of China ; National Program for Key Basic Research Projects of China
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]PARKINSONS-DISEASE ; ALPHA-SYNUCLEIN ; MODEL ; ANALOGS ; SYSTEM
英文摘要

Parkinson′s disease (PD) is characterized by the progressive degeneration of dopaminergic neurons in substantia nigra (SN) with the presence of alpha-synuclein inclusions termed Lewy bodies. The neuroprotective effects of protocatechuic acid (PAc) both in vitro and in vivo have been reported. However, little is known about the effects of PAc on neurotoxicity induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in vivo. In this study, we demonstrated that PAc inhibited the reduction of the latent periods in a rotarod test, and the contents of dopamine (DA) and its metabolites in striatum, and furthermore, it ameliorated the pathology in SN and the decreases in the expression of tyrosine hydroxylase (TH) in SN of C578L/6J mice induced by MPTP. Taken together, our results indicate for the first time that PAc has neuroprotective effects on MPTP treated C57BL/6J mice and may be useful in clinical treatment of PD. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

语种英语
所属项目编号2004CB518902
资助者National Program for Key Basic Research Projects of China ; National Program for Key Basic Research Projects of China
WOS记录号WOS:000277534800008
Citation statistics
Cited Times:21[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57948
Collection北京大学药学院
作者单位1.Peking Univ, Sch Pharmaceut Sci, Dept Mol & Cellular Pharmacol, Beijing 100191, Peoples R China
2.Peking Univ, State Key Lab Nat & Bionrimet Drugs, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Hong-Ning,An, Chun-Na,Zhang, Hui-Nan,et al. Protocatechuic acid inhibits neurotoxicity induced by MPTP in vivo[J]. NEUROSCIENCE LETTERS,2010,474(2):99-103.
APA Zhang, Hong-Ning,An, Chun-Na,Zhang, Hui-Nan,&Pu, Xiao-Ping.(2010).Protocatechuic acid inhibits neurotoxicity induced by MPTP in vivo.NEUROSCIENCE LETTERS,474(2),99-103.
MLA Zhang, Hong-Ning,et al."Protocatechuic acid inhibits neurotoxicity induced by MPTP in vivo".NEUROSCIENCE LETTERS 474.2(2010):99-103.
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