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学科主题临床医学
Upregulated MicroRNA-155 Expression in Peripheral Blood Mononuclear Cells and Fibroblast-Like Synoviocytes in Rheumatoid Arthritis
Long, Li1,2,3; Yu, Ping1,4; Liu, Yanying1; Wang, Shiyao1; Li, Ru1; Shi, Jinxia1; Zhang, Xiaoping1,5; Li, Yanmei1,5; Sun, Xiaolin1; Zhou, Bin2,3; Cui, Liufu4; Li, Zhanguo1
刊名CLINICAL & DEVELOPMENTAL IMMUNOLOGY
2013
DOI10.1155/2013/296139
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology
研究领域[WOS]Immunology
关键词[WOS]BIOGENESIS ; COMPLEX ; ROLES
英文摘要

Objective. This study was to screen for the miRNAs differently expressed in peripheral blood mononuclear cells (PBMC) of RA, to further identify the expression of miR-155 in RA PBMC and fibroblast-like synoviocytes (FLS), and to evaluate the function of miR-155 in RA-FLS. Methods. Microarray was used to screen for differentially expressed miRNAs in RA PBMC. miR-155 expression in PBMC and FLS of RA were identified by real-time PCR. Enforced overexpression and downexpression of miR-155 were used to investigate the function of miR-155 in RA-FLS. Expression of IKBKE which was previously identified as the actual target of miR-155 was examined by Western blot and real-time PCR in RA-FLS. Results. miR-155 levels were increased in both PBMC and FLS of RA and could be induced by TNF-alpha. Upregulation of miR-155 decreased MMP-3 levels and suppressed proliferation and invasion of RA-FLS. Inverse relationship between the expressions of miR-155 and the MMPs production-related protein IKBKE was found. Conclusion. An inflammatory milieu may alter miRNA expression profiles in rheumatoid arthritis. miR-155 is upregulated in RA-FLS, and it may be a protective factor against the inflammatory effect in part by attenuating expression of IKBKE.

语种英语
WOS记录号WOS:000325064700001
项目编号2008BA159B01 ; 81102272 ; 12040820382 ; 2010CB529100
资助机构National Key Technology R&amp ; D Program in the 11th Five Year Plan of China ; National Natural Science Foundation of China ; Chinese Medical Association Foundation ; Major State Basic Research Development Program of China (973 Program)
引用统计
被引频次:34[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57949
专题北京大学第二临床医学院
作者单位1.Sichuan Prov Peoples Hosp, Chengdu 610072, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Rheumatol & Immunol, Beijing 100044, Peoples R China
3.Sichuan Acad Med Sci, Dept Rheumatol & Immunol, Chengdu 610072, Peoples R China
4.Kailuan Gen Hosp, Dept Rheumatol & Immunol, Tangshan 063000, Peoples R China
5.Weifang Med Univ, Dept Rheumatol & Immunol, Weifang 261053, Peoples R China
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GB/T 7714
Long, Li,Yu, Ping,Liu, Yanying,et al. Upregulated MicroRNA-155 Expression in Peripheral Blood Mononuclear Cells and Fibroblast-Like Synoviocytes in Rheumatoid Arthritis[J]. CLINICAL & DEVELOPMENTAL IMMUNOLOGY,2013.
APA Long, Li.,Yu, Ping.,Liu, Yanying.,Wang, Shiyao.,Li, Ru.,...&Li, Zhanguo.(2013).Upregulated MicroRNA-155 Expression in Peripheral Blood Mononuclear Cells and Fibroblast-Like Synoviocytes in Rheumatoid Arthritis.CLINICAL & DEVELOPMENTAL IMMUNOLOGY.
MLA Long, Li,et al."Upregulated MicroRNA-155 Expression in Peripheral Blood Mononuclear Cells and Fibroblast-Like Synoviocytes in Rheumatoid Arthritis".CLINICAL & DEVELOPMENTAL IMMUNOLOGY (2013).
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