北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第三临床医学院  > 运动医学研究所  > 期刊论文
学科主题: 临床医学
题名:
Repair of articular cartilage defects in the knee with autologous iliac crest cartilage in a rabbit model
作者: Jing, Lizhong1; Zhang, Jiying1; Leng, Huijie2; Guo, Qinwei1; Hu, Yuelin1
关键词: Iliac crest cartilage ; Cartilage repair ; Cartilage defect ; Histology ; Magnetic resonance imaging ; Mechanical properties
刊名: KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
发表日期: 2015-04-01
DOI: 10.1007/s00167-014-2906-8
卷: 23, 期:4, 页:1119-1127
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Orthopedics ; Sport Sciences ; Surgery
研究领域[WOS]: Orthopedics ; Sport Sciences ; Surgery
关键词[WOS]: BONE MORPHOGENETIC PROTEIN-4 ; OSTEOCHONDRAL LESIONS ; MARROW STIMULATION ; TRANSPLANTATION ; MICROSCOPY ; TISSUE ; TALUS ; MICROFRACTURE ; AUTOGRAFT ; GROWTH
英文摘要:

To demonstrate that iliac crest cartilage may be used to repair articular cartilage defects in the knees of rabbits.

Full-thickness cartilage defects were created in the medial femoral condyle on both knees of 36 New Zealand white rabbits. The 72 defects were randomly assigned to be repaired with ipsilateral iliac crest cartilage (Group I), osteochondral tissues removed at defect creation (Group II), or no treatment (negative control, Group III). Animals were killed at 6, 12, and 24 weeks post-operatively. The repaired tissues were harvested for magnetic resonance imaging (MRI), histological studies (haematoxylin and eosin and immunohistochemical staining), and mechanical testing.

At 6 weeks, the iliac crest cartilage graft was not yet well integrated with the surrounding articular cartilage, but at 12 weeks, the graft deep zone had partial ossification. By 24 weeks, the hyaline cartilage-like tissue was completely integrated with the surrounding articular cartilage. Osteochondral autografts showed more rapid healing than Group I at 6 weeks and complete healing at 12 weeks. Untreated defects were concave or partly filled with fibrous tissue throughout the study. MRI showed that Group I had slower integration with surrounding normal cartilage compared with Group II. The mechanical properties of Group I were significantly lower than those of Group II at 12 weeks, but this difference was not significant at 24 weeks.

Iliac crest cartilage autografts were able to repair knee cartilage defects with hyaline cartilage and showed comparable results with osteochondral autografts in the rabbit model.

语种: 英语
WOS记录号: WOS:000351611700029
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57950
Appears in Collections:北京大学第三临床医学院_运动医学研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Hosp 3, Inst Sports Med, Beijing 100191, Peoples R China
2.Peking Univ, Orthoped Surg, Hosp 3, Beijing 100191, Peoples R China

Recommended Citation:
Jing, Lizhong,Zhang, Jiying,Leng, Huijie,et al. Repair of articular cartilage defects in the knee with autologous iliac crest cartilage in a rabbit model[J]. KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY,2015,23(4):1119-1127.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Jing, Lizhong]'s Articles
[Zhang, Jiying]'s Articles
[Leng, Huijie]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Jing, Lizhong]‘s Articles
[Zhang, Jiying]‘s Articles
[Leng, Huijie]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace