IR@PKUHSC  > 北京大学第三临床医学院  > 运动医学研究所
学科主题临床医学
Repair of articular cartilage defects in the knee with autologous iliac crest cartilage in a rabbit model
Jing, Lizhong1; Zhang, Jiying1; Leng, Huijie2; Guo, Qinwei1; Hu, Yuelin1
关键词Iliac Crest Cartilage Cartilage Repair Cartilage Defect Histology Magnetic Resonance Imaging Mechanical Properties
刊名KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
2015-04-01
DOI10.1007/s00167-014-2906-8
23期:4页:1119-1127
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Orthopedics ; Sport Sciences ; Surgery
研究领域[WOS]Orthopedics ; Sport Sciences ; Surgery
关键词[WOS]BONE MORPHOGENETIC PROTEIN-4 ; OSTEOCHONDRAL LESIONS ; MARROW STIMULATION ; TRANSPLANTATION ; MICROSCOPY ; TISSUE ; TALUS ; MICROFRACTURE ; AUTOGRAFT ; GROWTH
英文摘要

To demonstrate that iliac crest cartilage may be used to repair articular cartilage defects in the knees of rabbits.

Full-thickness cartilage defects were created in the medial femoral condyle on both knees of 36 New Zealand white rabbits. The 72 defects were randomly assigned to be repaired with ipsilateral iliac crest cartilage (Group I), osteochondral tissues removed at defect creation (Group II), or no treatment (negative control, Group III). Animals were killed at 6, 12, and 24 weeks post-operatively. The repaired tissues were harvested for magnetic resonance imaging (MRI), histological studies (haematoxylin and eosin and immunohistochemical staining), and mechanical testing.

At 6 weeks, the iliac crest cartilage graft was not yet well integrated with the surrounding articular cartilage, but at 12 weeks, the graft deep zone had partial ossification. By 24 weeks, the hyaline cartilage-like tissue was completely integrated with the surrounding articular cartilage. Osteochondral autografts showed more rapid healing than Group I at 6 weeks and complete healing at 12 weeks. Untreated defects were concave or partly filled with fibrous tissue throughout the study. MRI showed that Group I had slower integration with surrounding normal cartilage compared with Group II. The mechanical properties of Group I were significantly lower than those of Group II at 12 weeks, but this difference was not significant at 24 weeks.

Iliac crest cartilage autografts were able to repair knee cartilage defects with hyaline cartilage and showed comparable results with osteochondral autografts in the rabbit model.

语种英语
WOS记录号WOS:000351611700029
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57950
专题北京大学第三临床医学院_运动医学研究所
作者单位1.Peking Univ, Hosp 3, Inst Sports Med, Beijing 100191, Peoples R China
2.Peking Univ, Orthoped Surg, Hosp 3, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Jing, Lizhong,Zhang, Jiying,Leng, Huijie,et al. Repair of articular cartilage defects in the knee with autologous iliac crest cartilage in a rabbit model[J]. KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY,2015,23(4):1119-1127.
APA Jing, Lizhong,Zhang, Jiying,Leng, Huijie,Guo, Qinwei,&Hu, Yuelin.(2015).Repair of articular cartilage defects in the knee with autologous iliac crest cartilage in a rabbit model.KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY,23(4),1119-1127.
MLA Jing, Lizhong,et al."Repair of articular cartilage defects in the knee with autologous iliac crest cartilage in a rabbit model".KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY 23.4(2015):1119-1127.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Jing, Lizhong]的文章
[Zhang, Jiying]的文章
[Leng, Huijie]的文章
百度学术
百度学术中相似的文章
[Jing, Lizhong]的文章
[Zhang, Jiying]的文章
[Leng, Huijie]的文章
必应学术
必应学术中相似的文章
[Jing, Lizhong]的文章
[Zhang, Jiying]的文章
[Leng, Huijie]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。