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学科主题: 药物依赖
题名:
Distinct resting-state brain activities in heroin-dependent individuals
作者: Zhang, Yi1,2; Tian, Jie1,3; Yuan, Kai1; Liu, Peng1; Zhuo, Lu1; Qin, Wei1; Zhao, Liyan4; Liu, Jixin1; von Deneen, Karen M.1,2; Klahr, Nelson J.2; Gold, Mark S.2; Liu, Yijun2
关键词: Heroin-dependent individuals ; Pattern classification ; Multi-voxel pattern analysis (MVPA) ; Non-negative matrix factorization (NMF) ; Support vector machine (SVM)
刊名: BRAIN RESEARCH
发表日期: 2011-07-21
DOI: 10.1016/j.brainres.2011.05.054
卷: 1402, 页:46-53
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: STRIATAL DOPAMINE RELEASE ; SUPPORT VECTOR MACHINES ; HUMAN VISUAL-CORTEX ; COCAINE ADDICTION ; ORBITOFRONTAL CORTEX ; NEUROIMAGING EVIDENCE ; SUBJECTIVE RESPONSES ; DRUG-ADDICTION ; FMRI DATA ; STRESS
英文摘要:

Previous functional imaging studies on heroin addicts have focused on abnormal brain functions based on specific tasks, while few fMRI studies concentrated on the resting-state abnormalities of heroin-dependent individuals. In the current study, we applied the pattern classification technique, which employs the feature extraction method of non-negative matrix factorization (NMF) and a support vector machine (SVM) classifier. Its main purpose was to characterize the discrepancy in activation patterns between heroin-dependent individuals and healthy subjects during the resting state. The results displayed a high accuracy in the activation pattern differences of the two groups, which included the orbitofrontal cortex pm, cingulate gyrus, frontal and para-limbic regions such as the anterior cingulate cortex (ACC), hippocampal/parahippocampal region, amygdala, caudate, putamen, as well as the posterior insula and thalamus. These findings indicate that significant biomarkers exist among the network of circuits that are involved in drug abuse. The implications from our study may help explain the behavioral and neuropsychological deficits in heroin-dependent individuals and shed light on the mechanisms underlying heroin addiction. (C) 2011 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 2010696503 ; 60901064 ; 30970774 ; 30873462 ; 30870685 ; 81000641 ; 81000640 ; 81071217 ; 31028010 ; 81071137 ; 2011CB707700 ; 2011CB707702
项目资助者: China Scholarship Council ; National Natural Science Foundation of China ; Project for the National Key Basic Research and Development Program (973) ; CAS ; Fundamental Research Funds for the Central Universities ; NARSAD
WOS记录号: WOS:000293312300006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57953
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: 1.Xidian Univ, Sch Life Sci & Technol, Life Sci Res Ctr, Xian 710071, Shaanxi, Peoples R China
2.Univ Florida, Dept Psychiat, McKnight Brain Inst, Gainesville, FL 32610 USA
3.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
4.Peking Univ, Natl Inst Drug Dependence, Beijing 100083, Peoples R China

Recommended Citation:
Zhang, Yi,Tian, Jie,Yuan, Kai,et al. Distinct resting-state brain activities in heroin-dependent individuals[J]. BRAIN RESEARCH,2011,1402:46-53.
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