IR@PKUHSC  > 北京大学口腔医学院
学科主题口腔医学
In vitro antifungal effect and inhibitory activity on biofilm formation of seven commercial mouthwashes
Fu, J.1; Wei, P.1; Zhao, C.1; He, C.2; Yan, Z.1; Hua, H.1
关键词Mouthwashes Antifungal Effect Candida Biofilm
刊名ORAL DISEASES
2014-11-01
DOI10.1111/odi.12242
20期:8页:815-820
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dentistry, Oral Surgery & Medicine
资助者Natural Science Foundation of China ; program for new clinical techniques and therapies of Peking University ; Natural Science Foundation of China ; program for new clinical techniques and therapies of Peking University
研究领域[WOS]Dentistry, Oral Surgery & Medicine
关键词[WOS]CANDIDA-ALBICANS ; DENTURE STOMATITIS ; FLUCONAZOLE ; SUSCEPTIBILITY ; RESISTANCE
英文摘要

ObjectiveTo investigate the antifungal ability of seven over-the-counter mouthwashes against planktonic and sessile Candida albicans and Candida krusei.

Materials and MethodsThe seven mouthwashes studied were Listerine((R)), compound chlorhexidine solution, povidone iodine solution (PV-I), cetylpyridinium chloride solution, Colgate((R)) Plax, Crest((R)) Prohealth Mouthwash, and NaHCO3. The antifungal ability of each mouthwash against ATCC90028, ATCC6258, and 10 clinical C.albicans isolates was tested using disk diffusion tests, the broth microdilution method, and biofilm testing with two different XTT-reduction assays. Fluconazole was used as a positive control, and the experiments were performed in triplicate.

ResultsChlorhexidine and cetylpyridinium chloride had the largest inhibition zones for ATCC90028 and ATCC6258 (18.63.5 and 19 +/- 1.6mm, respectively). Cetylpyridinium chloride was the most effective at inhibiting all of the planktonic C.albicans strains and ATCC6258 with the minimum inhibitory concentration (MIC). As the maturity of the biofilms increased, the change in sessile cell MIC of the mouthwashes was much smaller than that of fluconazole. For the mature biofilms, chlorhexidine, PV-I, and cetylpyridinium chloride produced the greatest reductions in metabolism (60-80%).

ConclusionMost of these seven mouthwashes had significant antifungal activity for both planktonic and sessile Candida species.

语种英语
所属项目编号81000441 ; 81371163
资助者Natural Science Foundation of China ; program for new clinical techniques and therapies of Peking University ; Natural Science Foundation of China ; program for new clinical techniques and therapies of Peking University
WOS记录号WOS:000344395800014
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57963
Collection北京大学口腔医学院
作者单位1.Peking Univ, Sch Stomatol, Dept Oral Med, Beijing 100081, Peoples R China
2.Peking Univ, Sch Stomatol, Dept Clin Lab, Beijing 100081, Peoples R China
Recommended Citation
GB/T 7714
Fu, J.,Wei, P.,Zhao, C.,et al. In vitro antifungal effect and inhibitory activity on biofilm formation of seven commercial mouthwashes[J]. ORAL DISEASES,2014,20(8):815-820.
APA Fu, J.,Wei, P.,Zhao, C.,He, C.,Yan, Z.,&Hua, H..(2014).In vitro antifungal effect and inhibitory activity on biofilm formation of seven commercial mouthwashes.ORAL DISEASES,20(8),815-820.
MLA Fu, J.,et al."In vitro antifungal effect and inhibitory activity on biofilm formation of seven commercial mouthwashes".ORAL DISEASES 20.8(2014):815-820.
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