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学科主题: 公共卫生
题名:
The Gene-Gene Interaction of INSIG-SCAP-SREBP Pathway on the Risk of Obesity in Chinese Children
作者: Liu, Fang-Hong; Song, Jie-Yun; Shang, Xiao-Rui; Meng, Xiang-Rui; Ma, Jun; Wang, Hai-Jun
刊名: BIOMED RESEARCH INTERNATIONAL
发表日期: 2014
DOI: 10.1155/2014/538564
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biotechnology & Applied Microbiology ; Medicine, Research & Experimental
研究领域[WOS]: Biotechnology & Applied Microbiology ; Research & Experimental Medicine
关键词[WOS]: CLEAVAGE-ACTIVATING PROTEIN ; ELEMENT-BINDING PROTEINS ; BODY-MASS INDEX ; CHILDHOOD OBESITY ; DEVELOPING-COUNTRIES ; GLUCOSE-HOMEOSTASIS ; VARIANT UPSTREAM ; COMMON VARIANTS ; ASSOCIATION ; POPULATION
英文摘要:

Background. Childhood obesity has become a global public health problem in recent years. This study aimed to explore the association of genetic variants in INSIG-SCAP-SREBP pathway with obesity in Chinese children. Methods. A case-control study was conducted, including 705 obese cases and 1,325 nonobese controls. We genotyped 15 single nucleotide polymorphisms (SNPs) of five genes in INSIG-SCAP-SREBP pathway, including insulin induced gene 1 (INSIG1), insulin induced gene 2 (INSIG2), SREBP cleavage-activating protein gene (SCAP), sterol regulatory element binding protein gene 1 (SREBP1), and sterol regulatory element binding protein gene 2 (SREBP2). We used generalized multifactor dimensionality reduction (GMDR) and logistic regression to investigate gene-gene interactions. Results. Single polymorphism analyses showed that SCAP rs12487736 and rs12490383 were nominally associated with obesity. We identified a 3-locus interaction on obesity inGMDR analyses (P = 0.001), involving 3 genetic variants of INSIG2, SCAP, and SREBP2. The individuals in high-risk group of the 3-locus combinations had a 79.9% increased risk of obesity compared with those in low-risk group (OR = 1.799, 95% CI: 1.475-2.193,P = 6.61 x 10(-9)). Conclusion. We identified interaction of three genes in INSIG-SCAP-SREBP pathway on risk of obesity, revealing that these genes affect obesity more likely through a complex interaction pattern than single gene effect.

语种: 英语
所属项目编号: 81172683 ; 2012CB517501
项目资助者: National Natural Science Foundation of China ; Major State Basic Research and Development Program of China (973 Program)
WOS记录号: WOS:000338072400001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57968
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: Peking Univ, Inst Child & Adolescent Hlth, Sch Publ Hlth, Beijing 100191, Peoples R China

Recommended Citation:
Liu, Fang-Hong,Song, Jie-Yun,Shang, Xiao-Rui,et al. The Gene-Gene Interaction of INSIG-SCAP-SREBP Pathway on the Risk of Obesity in Chinese Children[J]. BIOMED RESEARCH INTERNATIONAL,2014.
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