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学科主题: 基础医学
题名:
The microrheological changes in the course of erythrocyte senescence after phenylhydrazine injection
作者: Xie, LD; Gu, L; Yan, ZY; Yao, WJ; Sun, DG; Wen, ZY
关键词: erythrocyte ; microrheological characteristics ; deformation indexes ; sedimentation ; new ektacytometry
刊名: CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
发表日期: 2003
卷: 28, 期:1, 页:5-11
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology ; Peripheral Vascular Disease
研究领域[WOS]: Hematology ; Cardiovascular System & Cardiology
关键词[WOS]: VISCOSITY
英文摘要:

To study the microrheological characteristics of RBCs during erythrocyte senescence in vivo, an anemia model of rabbit induced by phenylhydrazine injection was developed. Measurements of the hematocrit, the deformation indexes, the blood viscosity and the sedimentation, etc. were performed in vivo for more than 60 days in the processes of RBC senescence. Obvious changes in the RBC′s rheological characteristics were found in this senescent model. Compared with our previously developed Wen′s model [1,2] in which the entire RBC population was nearly synchronously produced following the induction of spherocytic anemia in the rabbit with antibody serum, the changes of RBC microrheological characteristics for this model showed approximately the same tendency, although Wen′s model with antibody serum was much better in its ability to simulation of the nearly normal physiological conditions than the present one with phenylhydrazine injection. Hence, the present model can serve as a model of RBC senescence under abnormal physiological conditions.

语种: 英语
WOS记录号: WOS:000181658600001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57969
Appears in Collections:基础医学院_生物物理学系_期刊论文

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作者单位: 1.Peking Univ, Dept Med Phys, Coll Med, Beijing 100083, Peoples R China
2.Peking Univ, Dept Mech & Engn Sci, Beijing 100871, Peoples R China

Recommended Citation:
Xie, LD,Gu, L,Yan, ZY,et al. The microrheological changes in the course of erythrocyte senescence after phenylhydrazine injection[J]. CLINICAL HEMORHEOLOGY AND MICROCIRCULATION,2003,28(1):5-11.
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