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学科主题基础医学
The microrheological changes in the course of erythrocyte senescence after phenylhydrazine injection
Xie, LD; Gu, L; Yan, ZY; Yao, WJ; Sun, DG; Wen, ZY
关键词Erythrocyte Microrheological Characteristics Deformation Indexes Sedimentation New Ektacytometry
刊名CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
2003
28期:1页:5-11
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology ; Peripheral Vascular Disease
研究领域[WOS]Hematology ; Cardiovascular System & Cardiology
关键词[WOS]VISCOSITY
英文摘要

To study the microrheological characteristics of RBCs during erythrocyte senescence in vivo, an anemia model of rabbit induced by phenylhydrazine injection was developed. Measurements of the hematocrit, the deformation indexes, the blood viscosity and the sedimentation, etc. were performed in vivo for more than 60 days in the processes of RBC senescence. Obvious changes in the RBC′s rheological characteristics were found in this senescent model. Compared with our previously developed Wen′s model [1,2] in which the entire RBC population was nearly synchronously produced following the induction of spherocytic anemia in the rabbit with antibody serum, the changes of RBC microrheological characteristics for this model showed approximately the same tendency, although Wen′s model with antibody serum was much better in its ability to simulation of the nearly normal physiological conditions than the present one with phenylhydrazine injection. Hence, the present model can serve as a model of RBC senescence under abnormal physiological conditions.

语种英语
WOS记录号WOS:000181658600001
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被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57969
专题北京大学基础医学院_生物物理学系
作者单位1.Peking Univ, Dept Med Phys, Coll Med, Beijing 100083, Peoples R China
2.Peking Univ, Dept Mech & Engn Sci, Beijing 100871, Peoples R China
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GB/T 7714
Xie, LD,Gu, L,Yan, ZY,et al. The microrheological changes in the course of erythrocyte senescence after phenylhydrazine injection[J]. CLINICAL HEMORHEOLOGY AND MICROCIRCULATION,2003,28(1):5-11.
APA Xie, LD,Gu, L,Yan, ZY,Yao, WJ,Sun, DG,&Wen, ZY.(2003).The microrheological changes in the course of erythrocyte senescence after phenylhydrazine injection.CLINICAL HEMORHEOLOGY AND MICROCIRCULATION,28(1),5-11.
MLA Xie, LD,et al."The microrheological changes in the course of erythrocyte senescence after phenylhydrazine injection".CLINICAL HEMORHEOLOGY AND MICROCIRCULATION 28.1(2003):5-11.
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