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学科主题临床医学
Appropriate insulin initiation dosage for insulin-naive type 2 diabetes outpatients receiving insulin monotherapy or in combination with metformin and/or pioglitazone
Liao Lin1; Yang Ming1,2; Qiu Lu-lu1; Mou Ya-ru1; Zhao Jia-jun1; Dong Jian-jun
关键词Initiation Dosage Insulin Metformin Pioglitazone Type 2 Diabetes
刊名CHINESE MEDICAL JOURNAL
2010-12-20
DOI10.3760/cma.j.issn.0366-6999.2010.24.031
123期:24页:3684-3688
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]THERAPY ; THIAZOLIDINEDIONES
英文摘要

Background Few studies have given suggestions on appropriate initiation insulin dosage when combined with oral antidiabetic drugs (OADs). This research was to investigate appropriate initiation insulin doses for insulin-naive type 2 diabetes patients with different combinations and the relationship between insulin dosage and relevant factors.

Methods This was a randomized, open-label, treat to target study. The target was 20% decrease of both fasting plasma glucose (FPG) and 2 hours post-breakfast blood glucose (P2hBG). One hundred and forty-seven insulin-naive Chinese patients recruited were randomly assigned to 3 groups: group A, patients received insulin monotherapy; group B, received insulin plus metformin (0.5 g, tid) and group C, received insulin plus metformin (0.5 g, tid) and pioglitazone (15 mg, qd). Insulin doses were initiated with a dose of 0.3 U.kg(-1).d(-1) and titrated according to FPG and P2hBG till reached the targets.

Results Both the time of getting 20% reduction of FPG and P2hBG showed significant differences among the three groups. The time was shortest in Group C. The insulin doses needed to achieve glucose reduction of 20% in three treatment groups were (0.40 +/- 0.04) U.kg(-1).d(-1) for Group A, (0.37 +/- 0.04) U.kg(-1).d(-1) for Group B, and (0.35 +/- 0.03) U.kg(-1).d(-1) for Group C, respectively. Multiple linear stepwise regression analysis showed that insulin doses correlated with body weight, FPG, diabetes duration, age and history of sulfonylurea treatment. The standardized regression coefficients were 0.871, 0.322, 0.089, 0.067 and 0.063 (with all P <0.05).

Conclusions To achieve blood glucose′s reduction of 20% within safety context, initial insulin doses were recommended as the following: 0.40 U.kg(-1).d(-1) for insulin mono-therapy, 0.37 U.kg(-1).d(-1) for insulin plus metformin treatment, and 0.35 U.kg(-1).d(-1) for insulin plus metformin and pioglitazone treatment in Chinese type 2 diabetes outpatients. Body weight is found the most closely related factor to the insulin dosage. Chin Med J 2011;124(24):3684-3688

语种英语
WOS记录号WOS:000285799200031
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57972
专题北京大学第二临床医学院
作者单位1.Shandong Univ, Prov Hosp, Dept Med, Div Endocrinol, Jinan 250021, Shandong, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Internal Med, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Liao Lin,Yang Ming,Qiu Lu-lu,et al. Appropriate insulin initiation dosage for insulin-naive type 2 diabetes outpatients receiving insulin monotherapy or in combination with metformin and/or pioglitazone[J]. CHINESE MEDICAL JOURNAL,2010,123(24):3684-3688.
APA Liao Lin,Yang Ming,Qiu Lu-lu,Mou Ya-ru,Zhao Jia-jun,&Dong Jian-jun.(2010).Appropriate insulin initiation dosage for insulin-naive type 2 diabetes outpatients receiving insulin monotherapy or in combination with metformin and/or pioglitazone.CHINESE MEDICAL JOURNAL,123(24),3684-3688.
MLA Liao Lin,et al."Appropriate insulin initiation dosage for insulin-naive type 2 diabetes outpatients receiving insulin monotherapy or in combination with metformin and/or pioglitazone".CHINESE MEDICAL JOURNAL 123.24(2010):3684-3688.
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