北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第二临床医学院  > 期刊论文
学科主题: 临床医学
题名:
Appropriate insulin initiation dosage for insulin-naive type 2 diabetes outpatients receiving insulin monotherapy or in combination with metformin and/or pioglitazone
作者: Liao Lin1; Yang Ming1,2; Qiu Lu-lu1; Mou Ya-ru1; Zhao Jia-jun1; Dong Jian-jun
关键词: initiation dosage ; insulin ; metformin ; pioglitazone ; type 2 diabetes
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2010-12-20
DOI: 10.3760/cma.j.issn.0366-6999.2010.24.031
卷: 123, 期:24, 页:3684-3688
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: THERAPY ; THIAZOLIDINEDIONES
英文摘要:

Background Few studies have given suggestions on appropriate initiation insulin dosage when combined with oral antidiabetic drugs (OADs). This research was to investigate appropriate initiation insulin doses for insulin-naive type 2 diabetes patients with different combinations and the relationship between insulin dosage and relevant factors.

Methods This was a randomized, open-label, treat to target study. The target was 20% decrease of both fasting plasma glucose (FPG) and 2 hours post-breakfast blood glucose (P2hBG). One hundred and forty-seven insulin-naive Chinese patients recruited were randomly assigned to 3 groups: group A, patients received insulin monotherapy; group B, received insulin plus metformin (0.5 g, tid) and group C, received insulin plus metformin (0.5 g, tid) and pioglitazone (15 mg, qd). Insulin doses were initiated with a dose of 0.3 U.kg(-1).d(-1) and titrated according to FPG and P2hBG till reached the targets.

Results Both the time of getting 20% reduction of FPG and P2hBG showed significant differences among the three groups. The time was shortest in Group C. The insulin doses needed to achieve glucose reduction of 20% in three treatment groups were (0.40 +/- 0.04) U.kg(-1).d(-1) for Group A, (0.37 +/- 0.04) U.kg(-1).d(-1) for Group B, and (0.35 +/- 0.03) U.kg(-1).d(-1) for Group C, respectively. Multiple linear stepwise regression analysis showed that insulin doses correlated with body weight, FPG, diabetes duration, age and history of sulfonylurea treatment. The standardized regression coefficients were 0.871, 0.322, 0.089, 0.067 and 0.063 (with all P <0.05).

Conclusions To achieve blood glucose′s reduction of 20% within safety context, initial insulin doses were recommended as the following: 0.40 U.kg(-1).d(-1) for insulin mono-therapy, 0.37 U.kg(-1).d(-1) for insulin plus metformin treatment, and 0.35 U.kg(-1).d(-1) for insulin plus metformin and pioglitazone treatment in Chinese type 2 diabetes outpatients. Body weight is found the most closely related factor to the insulin dosage. Chin Med J 2011;124(24):3684-3688

语种: 英语
WOS记录号: WOS:000285799200031
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57972
Appears in Collections:北京大学第二临床医学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Shandong Univ, Prov Hosp, Dept Med, Div Endocrinol, Jinan 250021, Shandong, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Internal Med, Beijing 100044, Peoples R China

Recommended Citation:
Liao Lin,Yang Ming,Qiu Lu-lu,et al. Appropriate insulin initiation dosage for insulin-naive type 2 diabetes outpatients receiving insulin monotherapy or in combination with metformin and/or pioglitazone[J]. CHINESE MEDICAL JOURNAL,2010,123(24):3684-3688.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Liao Lin]'s Articles
[Yang Ming]'s Articles
[Qiu Lu-lu]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Liao Lin]‘s Articles
[Yang Ming]‘s Articles
[Qiu Lu-lu]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace