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Alterations in Regional Brain Volume and Individual MRI-Guided Perfusion in Normal Control, Stable Mild Cognitive Impairment, and MCI-AD Converter
Wang, Huali1,4; Golob, Edward5; Bert, Alberto2; Nie, Ke1,2; Chu, Yong; Dick, Malcolm B.3; Mandelkern, Mark1,2; Su, Min-Ying1
关键词Mild Cognitive Impairment Medial Temporal Lobe Perfusion Volume Memory-function
刊名JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY
2009-03-01
DOI10.1177/0891988708328212
22期:1页:35-45
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Geriatrics & Gerontology ; Clinical Neurology ; Psychiatry
资助者National Center for Research Resources ; National Center for Research Resources
研究领域[WOS]Geriatrics & Gerontology ; Neurosciences & Neurology ; Psychiatry
关键词[WOS]ALZHEIMERS-DISEASE ; BLOOD-FLOW ; HIPPOCAMPAL VOLUME ; GLUCOSE-METABOLISM ; GRAY-MATTER ; SPECT ; MEMORY ; TOMOGRAPHY ; PREDICTION ; ABNORMALITIES
英文摘要

Regional differences in tissue volume and perfusion in brains of individuals with mild cognitive impairment (MCI) versus normal healthy age-matched controls (NC), and the differences between MCI-AD converters and stable MCI patients were investigated. MRI and SPECT scans were performed on 13 MCI (74 +/- 6 years) and 12 NC (75 +/- 4 years). Of the MCI patients, 10 were followed for up to three years and 4 subsequently converted to Alzheimer′s disease (AD). Episodic memory function was assessed using tests of delayed recall for word lists and stories. The volume reductions and hypoperfusion were mainly confined to the medial temporal lobe (MTL) of MCI patients and associated with worse scores on memory tests. Perfusion in the corpus callosum and the gray matter of frontal, lateral temporal, parietal or occipital lobe was not significantly affected in MCI. The 4 MCI-AD converters had relatively low MTL structural volume and perfusion compared to their stable peers.

语种英语
所属项目编号P50 AG16573 ; M01 RR00827
资助者National Center for Research Resources ; National Center for Research Resources
WOS记录号WOS:000263475400004
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57974
专题北京大学精神卫生研究所
作者单位1.Univ Calif Irvine, CFOI, Irvine, CA 92697 USA
2.Univ Calif Irvine, Dept Phys, Irvine, CA 92697 USA
3.Univ Calif Irvine, Inst Brain Aging & Dementia, Irvine, CA 92697 USA
4.Peking Univ, Inst Mental Hlth, Dept Geriatr Psychiat, Beijing 100871, Peoples R China
5.Tulane Univ, Dept Psychol, New Orleans, LA 70118 USA
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Wang, Huali,Golob, Edward,Bert, Alberto,et al. Alterations in Regional Brain Volume and Individual MRI-Guided Perfusion in Normal Control, Stable Mild Cognitive Impairment, and MCI-AD Converter[J]. JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY,2009,22(1):35-45.
APA Wang, Huali.,Golob, Edward.,Bert, Alberto.,Nie, Ke.,Chu, Yong.,...&Su, Min-Ying.(2009).Alterations in Regional Brain Volume and Individual MRI-Guided Perfusion in Normal Control, Stable Mild Cognitive Impairment, and MCI-AD Converter.JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY,22(1),35-45.
MLA Wang, Huali,et al."Alterations in Regional Brain Volume and Individual MRI-Guided Perfusion in Normal Control, Stable Mild Cognitive Impairment, and MCI-AD Converter".JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY 22.1(2009):35-45.
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