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学科主题: 精神卫生
题名:
Alterations in Regional Brain Volume and Individual MRI-Guided Perfusion in Normal Control, Stable Mild Cognitive Impairment, and MCI-AD Converter
作者: Wang, Huali1,4; Golob, Edward5; Bert, Alberto2; Nie, Ke1,2; Chu, Yong; Dick, Malcolm B.3; Mandelkern, Mark1,2; Su, Min-Ying1
关键词: mild cognitive impairment ; medial temporal lobe ; perfusion ; volume ; memory-function
刊名: JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY
发表日期: 2009-03-01
DOI: 10.1177/0891988708328212
卷: 22, 期:1, 页:35-45
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Geriatrics & Gerontology ; Clinical Neurology ; Psychiatry
研究领域[WOS]: Geriatrics & Gerontology ; Neurosciences & Neurology ; Psychiatry
关键词[WOS]: ALZHEIMERS-DISEASE ; BLOOD-FLOW ; HIPPOCAMPAL VOLUME ; GLUCOSE-METABOLISM ; GRAY-MATTER ; SPECT ; MEMORY ; TOMOGRAPHY ; PREDICTION ; ABNORMALITIES
英文摘要:

Regional differences in tissue volume and perfusion in brains of individuals with mild cognitive impairment (MCI) versus normal healthy age-matched controls (NC), and the differences between MCI-AD converters and stable MCI patients were investigated. MRI and SPECT scans were performed on 13 MCI (74 +/- 6 years) and 12 NC (75 +/- 4 years). Of the MCI patients, 10 were followed for up to three years and 4 subsequently converted to Alzheimer′s disease (AD). Episodic memory function was assessed using tests of delayed recall for word lists and stories. The volume reductions and hypoperfusion were mainly confined to the medial temporal lobe (MTL) of MCI patients and associated with worse scores on memory tests. Perfusion in the corpus callosum and the gray matter of frontal, lateral temporal, parietal or occipital lobe was not significantly affected in MCI. The 4 MCI-AD converters had relatively low MTL structural volume and perfusion compared to their stable peers.

语种: 英语
所属项目编号: P50 AG16573 ; M01 RR00827
项目资助者: National Center for Research Resources
WOS记录号: WOS:000263475400004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57974
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Univ Calif Irvine, CFOI, Irvine, CA 92697 USA
2.Univ Calif Irvine, Dept Phys, Irvine, CA 92697 USA
3.Univ Calif Irvine, Inst Brain Aging & Dementia, Irvine, CA 92697 USA
4.Peking Univ, Inst Mental Hlth, Dept Geriatr Psychiat, Beijing 100871, Peoples R China
5.Tulane Univ, Dept Psychol, New Orleans, LA 70118 USA

Recommended Citation:
Wang, Huali,Golob, Edward,Bert, Alberto,et al. Alterations in Regional Brain Volume and Individual MRI-Guided Perfusion in Normal Control, Stable Mild Cognitive Impairment, and MCI-AD Converter[J]. JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY,2009,22(1):35-45.
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