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学科主题: 基础医学
题名:
RNA-dependent RNA polymerase gene sequence from foot-and-mouth disease virus in Hong Kong
作者: Chen, X; Feng, Q; Wu, ZY; Liu, YY; Huang, K; Shi, R; Chen, SD; Lu, W; Ding, MX; Collins, RA; Fung, YWW; Lau, LT; Yu, ACH; Chen, JG
关键词: foot-and-mouth disease virus ; hypermutation ; RNA-dependent RNA polymerase ; sequence aliginment ; serotype ; 3D(pol) gene
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2003-09-05
DOI: 10.1016/S0006-291X(03)01511-0
卷: 308, 期:4, 页:899-905
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: POLIOVIRUS ; SEROTYPE ; MOTIFS
英文摘要:

A foot-and-mouth disease virus (FM DV, HKN/2002) was isolated in Hong Kong in 2002. The nucleotide sequence of the 3D(pol) gene encoding the viral RNA-dependent RNA polymerase was determined and compared with that of the same gene from other FMDVs. The 3D(pol) gene was 1410 nucleotides in length encoding a protein of 470 amino acid residues. Sequence comparisons indicated that HKN/2002 belonged to serotype O. An evolutionary tree based on the 3D(pol) sequences of 20 FMDV isolates revealed that the nucleotide sequence of the HKN/2002 3D(pol) gene was most similar to those of isolates found in Taiwan in 1997, Suggesting that they share a common ancestor. The amino acid sequence of the HKN/2002 3D(pol) gene was determined and aligned with those of representative isolates from seven other Picornaviridae genera. Eight highly conserved regions were detected, indicating a conserved functional relevance for these motifs. Alignment of 20 FMDV 3D(pol) amino acid sequences revealed a hypermutation region near the N-terminus that may help the virus evade host immune systems. (C) 2003 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000185168200034
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57979
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: 1.Peking Univ, Ctr Theoret Biol, Beijing 100871, Peoples R China
2.Peking Univ, Coll Life Sci, Dept Cell Biol & Genet, Beijing 100871, Peoples R China
3.Hong Kong DNA Chips Ltd, Cosmos Ctr, Kowloon, Hong Kong, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Dept Neurobiol, Neurosci Res Inst, Beijing 100083, Peoples R China

Recommended Citation:
Chen, X,Feng, Q,Wu, ZY,et al. RNA-dependent RNA polymerase gene sequence from foot-and-mouth disease virus in Hong Kong[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2003,308(4):899-905.
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