北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第二临床医学院  > 期刊论文
学科主题: 临床医学
题名:
Vagal Effects on the Occurrence of Focal Atrial Fibrillation Originating From the Pulmonary Veins
作者: Liu, Peng1; Guo, Ji-Hong2; Zhang, Hai-Cheng2; Wang, Ming-Xiao1; Li, Xue-Bin2; Zhang, Ping2; Yi, Zhong1; Sun, Jian-Ling1
关键词: Atrial fibrillation ; Autonomic nervous system ; Electrophysiology ; Veins
刊名: CIRCULATION JOURNAL
发表日期: 2009
卷: 73, 期:1, 页:48-54
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: ARRHYTHMOGENIC ACTIVITY ; CATHETER ABLATION ; REFRACTORINESS ; STIMULATION ; ARRHYTHMIAS ; INITIATION ; SUBSTRATE ; HUMANS ; MODEL
英文摘要:

Background There is evidence that the autonomic nervous system may be involved in the mechanism of focal atrial fibrillation (AF), so the present study investigated the effects of the parasympathetic nervous system on the occurrence of focal AF originating from the pulmonary veins (PVs). Methods and Results In 10 mongrel dogs, programmed stimulation and local burst stimulation (12.5Hz, impulse duration 0.5 ms) were performed at each of the PVs. Pacing thresholds at different sites were determined and shown as a terraced distribution. The closer to the ostium of the PV, the lower was the pacing threshold (P<0.05-0.001). The local effective refractory period (ERP), AF induction and AF threshold were measured at baseline and during bilateral vagal nerve stimulation (VNS). VNS led to local ERP shortening at each of the PV sites (P<0.05-0.001), increased the inducibility of AF at all sites in the 4 PVs (P<0.05-0.001), and decreased the AF threshold at most sites, especially in the distal portions of the 4 PVs (P<0.05-0.01). Conclusions VNS changes the electrophysiological characteristics of the PVs and facilitates the induction of AF Interaction between the autonomic nervous system and local cardiac autonomic nerve system may be a potential mechanism.

语种: 英语
所属项目编号: 30471710
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000262058800009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57985
Appears in Collections:北京大学第二临床医学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.China Meitan Gen Hosp, Dept Cardiovasc Med, Beijing, Peoples R China
2.Beijing Univ, Peoples Hosp, Dept Clin Electrophysiol, Beijing 100871, Peoples R China

Recommended Citation:
Liu, Peng,Guo, Ji-Hong,Zhang, Hai-Cheng,et al. Vagal Effects on the Occurrence of Focal Atrial Fibrillation Originating From the Pulmonary Veins[J]. CIRCULATION JOURNAL,2009,73(1):48-54.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Liu, Peng]'s Articles
[Guo, Ji-Hong]'s Articles
[Zhang, Hai-Cheng]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Liu, Peng]‘s Articles
[Guo, Ji-Hong]‘s Articles
[Zhang, Hai-Cheng]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace