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学科主题临床医学
Vagal Effects on the Occurrence of Focal Atrial Fibrillation Originating From the Pulmonary Veins
Liu, Peng1; Guo, Ji-Hong2; Zhang, Hai-Cheng2; Wang, Ming-Xiao1; Li, Xue-Bin2; Zhang, Ping2; Yi, Zhong1; Sun, Jian-Ling1
关键词Atrial Fibrillation Autonomic Nervous System Electrophysiology Veins
刊名CIRCULATION JOURNAL
2009
73期:1页:48-54
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]ARRHYTHMOGENIC ACTIVITY ; CATHETER ABLATION ; REFRACTORINESS ; STIMULATION ; ARRHYTHMIAS ; INITIATION ; SUBSTRATE ; HUMANS ; MODEL
英文摘要

Background There is evidence that the autonomic nervous system may be involved in the mechanism of focal atrial fibrillation (AF), so the present study investigated the effects of the parasympathetic nervous system on the occurrence of focal AF originating from the pulmonary veins (PVs). Methods and Results In 10 mongrel dogs, programmed stimulation and local burst stimulation (12.5Hz, impulse duration 0.5 ms) were performed at each of the PVs. Pacing thresholds at different sites were determined and shown as a terraced distribution. The closer to the ostium of the PV, the lower was the pacing threshold (P<0.05-0.001). The local effective refractory period (ERP), AF induction and AF threshold were measured at baseline and during bilateral vagal nerve stimulation (VNS). VNS led to local ERP shortening at each of the PV sites (P<0.05-0.001), increased the inducibility of AF at all sites in the 4 PVs (P<0.05-0.001), and decreased the AF threshold at most sites, especially in the distal portions of the 4 PVs (P<0.05-0.01). Conclusions VNS changes the electrophysiological characteristics of the PVs and facilitates the induction of AF Interaction between the autonomic nervous system and local cardiac autonomic nerve system may be a potential mechanism.

语种英语
WOS记录号WOS:000262058800009
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57985
专题北京大学第二临床医学院
北京大学临床肿瘤学院_药剂科
作者单位1.China Meitan Gen Hosp, Dept Cardiovasc Med, Beijing, Peoples R China
2.Beijing Univ, Peoples Hosp, Dept Clin Electrophysiol, Beijing 100871, Peoples R China
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GB/T 7714
Liu, Peng,Guo, Ji-Hong,Zhang, Hai-Cheng,et al. Vagal Effects on the Occurrence of Focal Atrial Fibrillation Originating From the Pulmonary Veins[J]. CIRCULATION JOURNAL,2009,73(1):48-54.
APA Liu, Peng.,Guo, Ji-Hong.,Zhang, Hai-Cheng.,Wang, Ming-Xiao.,Li, Xue-Bin.,...&Sun, Jian-Ling.(2009).Vagal Effects on the Occurrence of Focal Atrial Fibrillation Originating From the Pulmonary Veins.CIRCULATION JOURNAL,73(1),48-54.
MLA Liu, Peng,et al."Vagal Effects on the Occurrence of Focal Atrial Fibrillation Originating From the Pulmonary Veins".CIRCULATION JOURNAL 73.1(2009):48-54.
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