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学科主题基础医学
Long-duration transcutaneous electric acupoint stimulation alters small-world brain functional networks
Zhang, Yue1; Jiang, Yin2; Glielmi, Christopher B.3; Li, Longchuan3; Hu, Xiaoping3; Wang, Xiaoying4; Han, Jisheng2; Zhang, Jue1; Cui, Cailian2; Fang, Jing1
关键词Small-world Brain functional networks Resting-state fMRI Long-duration transcutaneous electric acupoint stimulation (TEAS)
刊名MAGNETIC RESONANCE IMAGING
2013-09-01
DOI10.1016/j.mri.2013.01.006
31期:7页:1105-1111
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Radiology, Nuclear Medicine & Medical Imaging
资助者National Basic Research Program of China ; Joint Research Project of HSC-COE PKU ; Georgia Tech/Emory University/Peking University seed grant ; National Basic Research Program of China ; Joint Research Project of HSC-COE PKU ; Georgia Tech/Emory University/Peking University seed grant
研究领域[WOS]Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]ORBITOFRONTAL CORTEX ; AFFECTIVE DIMENSION ; ACUPUNCTURE ; FMRI ; PAIN ; CONNECTIVITY ; MECHANISMS ; FREQUENCY ; PERFUSION ; SCHIZOPHRENIA
英文摘要

Acupuncture, which is recognized as an alternative and complementary treatment in Western medicine, has long shown efficiencies in chronic pain relief, drug addiction treatment, stroke rehabilitation and other clinical practices. The neural mechanism underlying acupuncture, however, is still unclear. Many studies have focused on the sustained effects of acupuncture on healthy subjects, yet there are very few on the topological organization of functional networks in the whole brain in response to long-duration acupuncture (longer than 20 min). This paper presents a novel study on the effects of long-duration transcutaneous electric acupoint stimulation (TEAS) on the small-world properties of brain functional networks. Functional magnetic resonance imaging was used to construct brain functional networks of 18 healthy subjects (9 males and 9 females) during the resting state. All subjects received both TEAS and minimal TEAS (MTEAS) and were scanned before and after each stimulation. An altered functional network was found with lower local efficiency and no significant change in global efficiency for healthy subjects after TEAS, while no significant difference was observed after MTEAS. The experiments also showed that the nodal efficiencies in several paralimbic/limbic regions were altered by TEAS, and those in middle frontal gyrus and other regions by MTEAS. To remove the psychological effects and the baseline, we compared the difference between diffTEAS (difference between after and before TEAS) and diffMTEAS (difference between after and before MTEAS). The results showed that the local efficiency was decreased and that the nodal efficiencies in frontal gyrus, orbitofrontal cortex, anterior cingulate gyrus and hippocampus gyrus were changed. Based on those observations, we conclude that long-duration TEAS may modulate the short-range connections of brain functional networks and also the limbic system. (c) 2013 Elsevier Inc. All rights reserved.

语种英语
所属项目编号2007CB512501 ; 2009CB522003
资助者National Basic Research Program of China ; Joint Research Project of HSC-COE PKU ; Georgia Tech/Emory University/Peking University seed grant ; National Basic Research Program of China ; Joint Research Project of HSC-COE PKU ; Georgia Tech/Emory University/Peking University seed grant
WOS记录号WOS:000322944600010
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57989
Collection北京大学基础医学院_神经生物学系
作者单位1.Peking Univ, Coll Engn, Beijing 100871, Peoples R China
2.Peking Univ, Neurosci Res Inst, Beijing 100191, Peoples R China
3.Emory Univ, Georgia Inst Technol, Dept Biomed Engn, Atlanta, GA 30322 USA
4.Peking Univ, Dept Radiol, Hosp 1, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Yue,Jiang, Yin,Glielmi, Christopher B.,et al. Long-duration transcutaneous electric acupoint stimulation alters small-world brain functional networks[J]. MAGNETIC RESONANCE IMAGING,2013,31(7):1105-1111.
APA Zhang, Yue.,Jiang, Yin.,Glielmi, Christopher B..,Li, Longchuan.,Hu, Xiaoping.,...&Fang, Jing.(2013).Long-duration transcutaneous electric acupoint stimulation alters small-world brain functional networks.MAGNETIC RESONANCE IMAGING,31(7),1105-1111.
MLA Zhang, Yue,et al."Long-duration transcutaneous electric acupoint stimulation alters small-world brain functional networks".MAGNETIC RESONANCE IMAGING 31.7(2013):1105-1111.
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