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学科主题: 药学
题名:
Update of Metal-Based Drugs : Problems and Approaches for Solution
作者: Huang Meiling; Wu Yaling; Zhao Pan; Yang Xiaoda
关键词: anti-cancer ; antidiabetic ; cisplatin ; vanadium
刊名: PROGRESS IN CHEMISTRY
发表日期: 2013-04-24
卷: 25, 期:4, 页:650-660
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
关键词[WOS]: INDUCED DIABETIC-RATS ; PLATINUM ANTICANCER DRUGS ; TYROSINE-PHOSPHATASE 1B ; DNA-BINDING PROPERTIES ; INSULIN-MIMETIC AGENT ; ACID VANADYL COMPLEX ; CELL-CYCLE ARREST ; OXOVANADIUM(IV) COMPLEXES ; SKELETAL-MUSCLE ; GENE-EXPRESSION
英文摘要:

From this century, great progresses have been made in the field of metal-based medicine and relevant fundamental researches. However, there are also major problems left to be solved. This review summarized the recent progresses and the bottlenecks of two important metal drugs, anti-cancer platinum/non-platinum drugs and anti-diabetic vanadium compounds. The following aspects are proposed for attentions in the future research: (1) Discover new molecular mechanism of metal drugs for rational design of metal drugs; (2) Control of metal toxicity based on molecular mechanism; (3) Rational metal drug design and metal drug delivery system based on nano materials, molecular complexes and drug transporters; (4) Synthetic biology of metal complexes.

语种: 中文
WOS记录号: WOS:000318131600022
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57994
Appears in Collections:北京大学药学院_化学生物学系_期刊论文

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作者单位: Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100191, Peoples R China

Recommended Citation:
Huang Meiling,Wu Yaling,Zhao Pan,et al. Update of Metal-Based Drugs : Problems and Approaches for Solution[J]. PROGRESS IN CHEMISTRY,2013,25(4):650-660.
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