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学科主题药学
Update of Metal-Based Drugs : Problems and Approaches for Solution
Huang Meiling; Wu Yaling; Zhao Pan; Yang Xiaoda
关键词Anti-cancer Antidiabetic Cisplatin Vanadium
刊名PROGRESS IN CHEMISTRY
2013-04-24
25期:4页:650-660
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary
研究领域[WOS]Chemistry
关键词[WOS]INDUCED DIABETIC-RATS ; PLATINUM ANTICANCER DRUGS ; TYROSINE-PHOSPHATASE 1B ; DNA-BINDING PROPERTIES ; INSULIN-MIMETIC AGENT ; ACID VANADYL COMPLEX ; CELL-CYCLE ARREST ; OXOVANADIUM(IV) COMPLEXES ; SKELETAL-MUSCLE ; GENE-EXPRESSION
英文摘要

From this century, great progresses have been made in the field of metal-based medicine and relevant fundamental researches. However, there are also major problems left to be solved. This review summarized the recent progresses and the bottlenecks of two important metal drugs, anti-cancer platinum/non-platinum drugs and anti-diabetic vanadium compounds. The following aspects are proposed for attentions in the future research: (1) Discover new molecular mechanism of metal drugs for rational design of metal drugs; (2) Control of metal toxicity based on molecular mechanism; (3) Rational metal drug design and metal drug delivery system based on nano materials, molecular complexes and drug transporters; (4) Synthetic biology of metal complexes.

语种中文
WOS记录号WOS:000318131600022
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57994
专题北京大学药学院_化学生物学系
作者单位Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100191, Peoples R China
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Huang Meiling,Wu Yaling,Zhao Pan,et al. Update of Metal-Based Drugs : Problems and Approaches for Solution[J]. PROGRESS IN CHEMISTRY,2013,25(4):650-660.
APA Huang Meiling,Wu Yaling,Zhao Pan,&Yang Xiaoda.(2013).Update of Metal-Based Drugs : Problems and Approaches for Solution.PROGRESS IN CHEMISTRY,25(4),650-660.
MLA Huang Meiling,et al."Update of Metal-Based Drugs : Problems and Approaches for Solution".PROGRESS IN CHEMISTRY 25.4(2013):650-660.
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