北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学公共卫生学院  > 期刊论文
学科主题: 公共卫生
题名:
Increased oxidative DNA damage, as assessed by urinary 8-hydroxy-2 ′-deoxyguanosine concentrations, and serum redox status in persons exposed to mercury
作者: Chen, CY; Qu, LY; Li, B; Xing, L; Jia, G; Wang, TC; Gao, YX; Zhang, PQ; Li, M; Chen, W; Chai, ZF
刊名: CLINICAL CHEMISTRY
发表日期: 2005-04-01
DOI: 10.1373/clinchem.2004.042093
卷: 51, 期:4, 页:759-767
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medical Laboratory Technology
研究领域[WOS]: Medical Laboratory Technology
关键词[WOS]: PERFORMANCE LIQUID-CHROMATOGRAPHY ; ELECTROCHEMICAL DETECTION ; GLUTATHIONE-PEROXIDASE ; HUMAN BLOOD ; METHYLMERCURY ; WORKERS ; 8-HYDROXYDEOXYGUANOSINE ; GENOTOXICITY ; CHLORIDE ; SELENIUM
英文摘要:

Background: Mercury is a ubiquitous and highly toxic environmental pollutant. In this study, we evaluated the relationship between mercury exposure and oxidative stress, serum and urinary mercury concentrations, oxidative DNA damage, and serum redox status in chronically mercury-exposed persons compared with healthy controls.

Methods: We measured urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG), which we used as a biomarker of oxidative DNA damage in the mercury-exposed persons, by HPLC with electrochemical detection (ECD). We evaluated antioxidant status by measuring the activities of superoxide dismutase and glutathione peroxidase and the concentrations of total reduced glutathione and protein-bound thiols in serum.

Results: The significant increase in 8-OHdG concentrations in urine indicated that mercury-induced oxidative damage to DNA occurred in vivo. Differences in body mercury burden and antioxidant enzyme activities were statistically significant between the mercury-exposed persons and controls. Serum and urinary mercury concentrations in the mercury-exposed persons were more than 40-fold higher than in controls.

Conclusions: Mercury exposure can induce oxidative DNA damage, whereas the antioxidative repair systems can be expected to minimize DNA lesions caused by mercury. Measurement of urinary 8-OHdG could be useful for evaluating in vivo oxidative DNA damage in mercury-exposed populations. (c) 2005 American Association for Clinical Chemistry.

语种: 英语
WOS记录号: WOS:000227936600011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57995
Appears in Collections:北京大学公共卫生学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Guizhou Res & Design Inst Environm Sci, Guiyang, Peoples R China
2.Chinese Acad Sci, Inst High Energy Phys, Key Lab Nucl Analyt Tech, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Inst High Energy Phys, Lab Nanoscale Mat & Related Bioenvironm Sci, Beijing 100049, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Beijing 100871, Peoples R China
5.Peking Univ, Hosp 3, Dept Clin Lab, Beijing 100871, Peoples R China

Recommended Citation:
Chen, CY,Qu, LY,Li, B,et al. Increased oxidative DNA damage, as assessed by urinary 8-hydroxy-2 ′-deoxyguanosine concentrations, and serum redox status in persons exposed to mercury[J]. CLINICAL CHEMISTRY,2005,51(4):759-767.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Chen, CY]'s Articles
[Qu, LY]'s Articles
[Li, B]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Chen, CY]‘s Articles
[Qu, LY]‘s Articles
[Li, B]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace