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Increased oxidative DNA damage, as assessed by urinary 8-hydroxy-2 ′-deoxyguanosine concentrations, and serum redox status in persons exposed to mercury
Chen, CY; Qu, LY; Li, B; Xing, L; Jia, G; Wang, TC; Gao, YX; Zhang, PQ; Li, M; Chen, W; Chai, ZF
刊名CLINICAL CHEMISTRY
2005-04-01
DOI10.1373/clinchem.2004.042093
51期:4页:759-767
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medical Laboratory Technology
研究领域[WOS]Medical Laboratory Technology
关键词[WOS]PERFORMANCE LIQUID-CHROMATOGRAPHY ; ELECTROCHEMICAL DETECTION ; GLUTATHIONE-PEROXIDASE ; HUMAN BLOOD ; METHYLMERCURY ; WORKERS ; 8-HYDROXYDEOXYGUANOSINE ; GENOTOXICITY ; CHLORIDE ; SELENIUM
英文摘要

Background: Mercury is a ubiquitous and highly toxic environmental pollutant. In this study, we evaluated the relationship between mercury exposure and oxidative stress, serum and urinary mercury concentrations, oxidative DNA damage, and serum redox status in chronically mercury-exposed persons compared with healthy controls.

Methods: We measured urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG), which we used as a biomarker of oxidative DNA damage in the mercury-exposed persons, by HPLC with electrochemical detection (ECD). We evaluated antioxidant status by measuring the activities of superoxide dismutase and glutathione peroxidase and the concentrations of total reduced glutathione and protein-bound thiols in serum.

Results: The significant increase in 8-OHdG concentrations in urine indicated that mercury-induced oxidative damage to DNA occurred in vivo. Differences in body mercury burden and antioxidant enzyme activities were statistically significant between the mercury-exposed persons and controls. Serum and urinary mercury concentrations in the mercury-exposed persons were more than 40-fold higher than in controls.

Conclusions: Mercury exposure can induce oxidative DNA damage, whereas the antioxidative repair systems can be expected to minimize DNA lesions caused by mercury. Measurement of urinary 8-OHdG could be useful for evaluating in vivo oxidative DNA damage in mercury-exposed populations. (c) 2005 American Association for Clinical Chemistry.

语种英语
WOS记录号WOS:000227936600011
引用统计
被引频次:72[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57995
专题北京大学公共卫生学院
作者单位1.Guizhou Res & Design Inst Environm Sci, Guiyang, Peoples R China
2.Chinese Acad Sci, Inst High Energy Phys, Key Lab Nucl Analyt Tech, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Inst High Energy Phys, Lab Nanoscale Mat & Related Bioenvironm Sci, Beijing 100049, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Beijing 100871, Peoples R China
5.Peking Univ, Hosp 3, Dept Clin Lab, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Chen, CY,Qu, LY,Li, B,et al. Increased oxidative DNA damage, as assessed by urinary 8-hydroxy-2 ′-deoxyguanosine concentrations, and serum redox status in persons exposed to mercury[J]. CLINICAL CHEMISTRY,2005,51(4):759-767.
APA Chen, CY.,Qu, LY.,Li, B.,Xing, L.,Jia, G.,...&Chai, ZF.(2005).Increased oxidative DNA damage, as assessed by urinary 8-hydroxy-2 ′-deoxyguanosine concentrations, and serum redox status in persons exposed to mercury.CLINICAL CHEMISTRY,51(4),759-767.
MLA Chen, CY,et al."Increased oxidative DNA damage, as assessed by urinary 8-hydroxy-2 ′-deoxyguanosine concentrations, and serum redox status in persons exposed to mercury".CLINICAL CHEMISTRY 51.4(2005):759-767.
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