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学科主题: 基础医学
题名:
The effects of curcumin on depressive-like behaviors in mice
作者: Xu, Y; Ku, BS; Yao, HY; Lin, YH; Ma, X; Zhang, YH; Li, XJ
关键词: curcumin ; forced swimming ; tail suspension ; locomotor activity ; antidepressant-like effect ; monoamine ; monoamine oxidase ; mice
刊名: EUROPEAN JOURNAL OF PHARMACOLOGY
发表日期: 2005-07-25
DOI: 10.1016/j.ejphar.2005.06.002
卷: 518, 期:1, 页:40-46
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: MONOAMINE-OXIDASE ACTIVITY ; BRAIN ; ANTIDEPRESSANTS ; INHIBITORS ; NEURONS ; DESPAIR ; LONGA ; DRUG ; RATS
英文摘要:

Curcuma longa is a major constituent of Xiaoyao-san, the traditional Chinese medicinal formula, which has been used effectively to treat depression-related diseases in China. There is no information available about the antidepressant activity of curcumin, the active component of curcuma longa. In the present study, we analyzed the effects of curcumin on depressive-like behaviors in mice, using two animal models of depression. Our results showed that curcumin treatment at 5 and 10 mg/kg (p.o.) significantly reduced the duration of immobility in both the tail suspension and forced swimming tests. These doses that affected the immobile response did not affect locomotor activity. In addition, the neurochemical assays showed that curcumin produced a marked increase of serotonin and noradrenaline levels at 10 mg/kg in both the frontal cortex and. hippocampus. Dopamine levels were also increased in the frontal cortex and the striatum. Moreover, curcumin was found to inhibit. monoamine oxidase activity in the mouse brain. These findings suggest that the antidepressant-like effects of curcumin may involve the central monoaminergic neurotransmitter-systems. (c) 2005 Elsevier B.V All rights reserved.

语种: 英语
WOS记录号: WOS:000230874800006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57998
Appears in Collections:基础医学院_药理学系_期刊论文

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作者单位: Peking Univ, Sch Basic Med Sci, Dept Pharmacol, Beijing 100083, Peoples R China

Recommended Citation:
Xu, Y,Ku, BS,Yao, HY,et al. The effects of curcumin on depressive-like behaviors in mice[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2005,518(1):40-46.
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