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学科主题基础医学
The effects of curcumin on depressive-like behaviors in mice
Xu, Y; Ku, BS; Yao, HY; Lin, YH; Ma, X; Zhang, YH; Li, XJ
关键词Curcumin Forced Swimming Tail Suspension Locomotor Activity Antidepressant-like Effect Monoamine Monoamine Oxidase Mice
刊名EUROPEAN JOURNAL OF PHARMACOLOGY
2005-07-25
DOI10.1016/j.ejphar.2005.06.002
518期:1页:40-46
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]MONOAMINE-OXIDASE ACTIVITY ; BRAIN ; ANTIDEPRESSANTS ; INHIBITORS ; NEURONS ; DESPAIR ; LONGA ; DRUG ; RATS
英文摘要

Curcuma longa is a major constituent of Xiaoyao-san, the traditional Chinese medicinal formula, which has been used effectively to treat depression-related diseases in China. There is no information available about the antidepressant activity of curcumin, the active component of curcuma longa. In the present study, we analyzed the effects of curcumin on depressive-like behaviors in mice, using two animal models of depression. Our results showed that curcumin treatment at 5 and 10 mg/kg (p.o.) significantly reduced the duration of immobility in both the tail suspension and forced swimming tests. These doses that affected the immobile response did not affect locomotor activity. In addition, the neurochemical assays showed that curcumin produced a marked increase of serotonin and noradrenaline levels at 10 mg/kg in both the frontal cortex and. hippocampus. Dopamine levels were also increased in the frontal cortex and the striatum. Moreover, curcumin was found to inhibit. monoamine oxidase activity in the mouse brain. These findings suggest that the antidepressant-like effects of curcumin may involve the central monoaminergic neurotransmitter-systems. (c) 2005 Elsevier B.V All rights reserved.

语种英语
WOS记录号WOS:000230874800006
引用统计
被引频次:132[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57998
专题北京大学基础医学院_药理学系
作者单位Peking Univ, Sch Basic Med Sci, Dept Pharmacol, Beijing 100083, Peoples R China
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GB/T 7714
Xu, Y,Ku, BS,Yao, HY,et al. The effects of curcumin on depressive-like behaviors in mice[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2005,518(1):40-46.
APA Xu, Y.,Ku, BS.,Yao, HY.,Lin, YH.,Ma, X.,...&Li, XJ.(2005).The effects of curcumin on depressive-like behaviors in mice.EUROPEAN JOURNAL OF PHARMACOLOGY,518(1),40-46.
MLA Xu, Y,et al."The effects of curcumin on depressive-like behaviors in mice".EUROPEAN JOURNAL OF PHARMACOLOGY 518.1(2005):40-46.
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