IR@PKUHSC  > 北京大学深圳医院
学科主题临床医学
Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54
Wang, Li-Dong1,2; Zhou, Fu-You2,3; Li, Xue-Min2,4; Sun, Liang-Dan5; Song, Xin1,2; Jin, Yan1; Li, Jiang-Man1,2; Kong, Guo-Qiang2; Qi, Hong2; Cui, Juan2; Zhang, Lian-Qun1; Yang, Jie-Zhi2; Li, Ji-Lin6; Li, Xing-Chuan2; Ren, Jing-Li2; Liu, Zhi-Cai7; Gao, Wen-Jun8; Yuan, Ling2,9; Wei, Wu10,11; Zhang, Yan-Rui12; Wang, Wei-Peng2,4; Sheyhidin, Ilyar13,14; Li, Feng15; Chen, Bao-Ping16; Ren, Shu-Wei17; Liu, Bin18; Li, Dan1,2; Ku, Jian-Wei19; Fan, Zong-Min2; Zhou, Sheng-Li1; Guo, Zhi-Gang1; Zhao, Xue-Ke1; Liu, Na1; Ai, Yong-Hong1; Shen, Fang-Fang1; Cui, Wen-Yan1; Song, Shuang2; Guo, Tao2; Huang, Jing2; Yuan, Chao2; Huang, Jia2; Wu, Yue2; Yue, Wen-Bin20; Feng, Chang-Wei2; Li, Hong-Lei2; Wang, Yan2; Tian, Jin-Ya2; Lu, Yue2; Yuan, Yi1; Zhu, Wen-Liang2; Liu, Min2; Fu, Wen-Jing2; Yang, Xia2; Wang, Han-Jing2; Han, Suo-Li2; Chen, Jie2; Han, Min21; Wang, Hai-Yan1; Zhang, Peng1; Li, Xiu-Min1; Dong, Jin-Cheng2; Xing, Guo-Lan2; Wang, Ran2; Guo, Ming2; Chang, Zhi-Wei2; Liu, Hai-Lin1; Guo, Li2; Yuan, Zhi-Qing1; Liu, Hai22; Lu, Qin2; Yang, Liu-Qin23; Zhu, Fu-Guo21; Yang, Xiu-Feng24; Feng, Xiao-Shan25; Wang, Zhou26; Li, Yin9; Gao, She-Gan25; Qige, Qirenwang27; Bai, Long-Tang27; Yang, Wen-Jun28; Lei, Guang-Yan29; Shen, Zhong-Ying30,31; Chen, Long-Qi32; Li, En-Min30,31; Xu, Li-Yan30,31; Wu, Zhi-Yong30,31; Cao, Wei-Ke33; Wang, Jian-Po2,3; Bao, Zhi-Qin4; Chen, Ji-Li4; Ding, Guang-Cheng2; Zhuang, Xiang2; Zhou, Ying-Fa2; Zheng, Hou-Feng5; Zhang, Zheng5; Zuo, Xian-Bo5; Dong, Zi-Ming2; Fan, Dong-Mei2; He, Xin2; Wang, Jin2; Zhou, Qi2; Zhang, Qin-Xian2; Jiao, Xin-Ying6; Lian, Shi-Yong7; Ji, Ai-Fang10,11; Lu, Xiao-Mei13,14; Wang, Jin-Sheng10,11; Chang, Fu-Bao8; Lu, Chang-Dong3; Chen, Zhi-Guo1; Miao, Jian-Jun4; Fan, Zeng-Lin4; Lin, Ruo-Bai34; Liu, Tai-Jiang35; Wei, Jin-Chang6; Kong, Qing-Peng36; Lan, Yu37; Fan, Yu-Jing37; Gao, Fu-Sheng18; Wang, Tian-Yun1; Xie, Dong38; Chen, Shu-Qing39; Yang, Wan-Cai1; Hong, Jun-Yan39; Wang, Liang1; Qiu, Song-Liang2; Cai, Zhi-Ming40; Zhang, Xue-Jun5
刊名NATURE GENETICS
2010-09-01
DOI10.1038/ng.648
42期:9页:759-U46
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Genetics & Heredity
研究领域[WOS]Genetics & Heredity
关键词[WOS]PHOSPHOLIPASE-C-EPSILON ; HIGH-INCIDENCE AREA ; FUNCTIONAL-CHARACTERIZATION ; NORTHERN CHINA ; RISK-FACTORS ; HAN CHINESE ; CANCER
英文摘要

We performed a genome-wide association study of esophageal squamous cell carcinoma (ESCC) by genotyping 1,077 individuals with ESCC and 1,733 control subjects of Chinese Han descent. We selected 18 promising SNPs for replication in an additional 7,673 cases of ESCC and 11,013 control subjects of Chinese Han descent and 303 cases of ESCC and 537 control subjects of Chinese Uygur-Kazakh descent. We identified two previously unknown susceptibility loci for ESCC: PLCE1 at 10q23 (P(Han combined) (for ESCC) = 7.46 x 10(-56), odds ratio (OR) = 1.43; P(Uygur-Kazakh for ESCC) = 5.70 x 10(-4), OR = 1.53) and C20orf54 at 20p13 (P(Han combined) (for ESCC) = 1.21 x 10(-11), OR = 0.86; P(Uygur-Kazakh for ESCC) = 7.88 x 10(-3), OR = 0.66). We also confirmed association in 2,766 cases of gastric cardia adenocarcinoma cases and the same 11,013 control subjects (PLCE1, P(Han for GCA) = 1.74 x 10(-39), OR = 1.55 and C20orf54, P(Han for GCA) = 3.02 x 10(-3), OR = 0.91). PLCE1 and C20orf54 have important biological implications for both ESCC and GCA. PLCE1 might regulate cell growth, differentiation, apoptosis and angiogenesis. C20orf54 is responsible for transporting riboflavin, and deficiency of riboflavin has been documented as a risk factor for ESCC and GCA.

语种英语
WOS记录号WOS:000281388400010
引用统计
被引频次:235[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58001
专题北京大学深圳医院
作者单位1.Xinyang Cent Hosp, Dept Oncol, Xinyang, Henan, Peoples R China
2.Peoples Hosp Puyang, Dept Oncol, Puyang, Henan, Peoples R China
3.Xinxiang Med Univ, Canc Res Ctr, Xinxiang, Henan, Peoples R China
4.Tumor Hosp Linzhou, Dept Thorac Surg, Linzhou, Henan, Peoples R China
5.Changzhi Med Univ, Inst Hematol Dis, Changzhi, Shanxi, Peoples R China
6.Changzhi Med Univ, Dept Pathol, Changzhi, Shanxi, Peoples R China
7.Zhengzhou Univ, Henan Key Lab Esophageal Canc Res, Dept Basic Oncol & Pathol, Coll Med,Affiliated Hosp 1& 2, Zhengzhou, Henan, Peoples R China
8.Anyang Tumor Hosp, Dept Thorac Surg & Tumor Prevent Treatment, Anyang, Henan, Peoples R China
9.Cixian Hosp, Dept Pathol & Thorac Surg, Ctr Hlth Screening & Endoscopy, Cixian, Hebei, Peoples R China
10.Anhui Med Univ, Minist Educ, Key Lab Dermatol, Hefei, Anhui, Peoples R China
11.Linzhou Esophageal Canc Hosp, Dept Pathol & Thorac Surg, Linzhou, Henan, Peoples R China
12.Peoples Hosp & Chinese Med Hosp Linzhou, Dept Thorac Surg, Linzhou, Henan, Peoples R China
13.Canc Hosp Henan Prov, Dept Thorac Surg & Radiotherapy, Zhengzhou, Henan, Peoples R China
14.Henan Prov Peoples Hosp, Dept Gastroenterol, Zhengzhou, Henan, Peoples R China
15.Xinjiang Med Univ, Affiliated Hosp 1, Dept Thorac Surg, Urumqi, Xinjiang, Peoples R China
16.Xinjiang Med Univ, Affiliated Hosp 1, Med Res Ctr, Urumqi, Xinjiang, Peoples R China
17.Shihezi Univ, Sch Med, Dept Pathol, Shihezi, Xinjiang, Peoples R China
18.Henan Univ, Huaihe Hosp, Dept Nephrol, Kaifeng, Henan, Peoples R China
19.Capital Med Univ, Beijing Tongren Hosp, Dept Gastroenterol, Beijing, Peoples R China
20.Nanyang Med Coll, Affiliated Hosp 1, Dept Oncol, Nanyang, Henan, Peoples R China
21.First Peoples Hosp Shangqiu, Dept Gastroenterol & Thorac Surg, Shangqiu, Henan, Peoples R China
22.Third Peoples Hosp Yunnan Prov, Dept Gastroenterol, Kunming, Yunnan, Peoples R China
23.Cent Hosp Xinxiang, Dept Radiotherapy, Xinxiang, Henan, Peoples R China
24.Hebi Dahejian Hosp, Dept Surg, Hebi, Henan, Peoples R China
25.Henan Univ Sci & Technol, Affiliated Hosp 1, Dept Oncol, Luoyang, Henan, Peoples R China
26.Shandong Univ, Dept Thorac Surg, Prov Hosp, Jinan 250100, Shandong, Peoples R China
27.Inner Mongolia Med Coll, Affiliated Hosp, Dept Internal Mongolia Med, Hohhot, Inner Mongolia, Peoples R China
28.Ningxia Med Univ, Dept Biotechnol, Ningxia, Peoples R China
29.Tumor Hosp Shaanxi Prov, Dept Thorac Surg, Xian, Shaanxi, Peoples R China
30.Shantou Univ, Coll Med, Dept Oncol Pathol, Shantou, Guangdong, Peoples R China
31.Shantou Univ, Coll Med, Dept Biochem & Mol Biol, Shantou, Guangdong, Peoples R China
32.Sichuan Univ, W China Hosp, Dept Thorac & Cardiovasc Surg, Chengdu 610064, Sichuan, Peoples R China
33.Nanjing Med Univ, Huaian Hosp 1, Cent Lab, Huaian, Jiangsu, Peoples R China
34.Fujian Med Univ, Dept Thorac Surg, Union Hosp, Fuzhou, Fujian, Peoples R China
35.Red Cross Hosp Huojia, Dept Surg, Xinxiang, Henan, Peoples R China
36.Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resource & Evolut, Kunming, Yunnan, Peoples R China
37.Peking Univ, Med Coll 4, Beijing Jishuitan Hosp, Dept Gastroenterol, Beijing 100871, Peoples R China
38.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai, Peoples R China
39.Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310003, Zhejiang, Peoples R China
40.Peking Univ, Shenzhen Hosp, Guangdong Key Lab Male Reprod Med & Genet, Shenzhen, Guangdong, Peoples R China
推荐引用方式
GB/T 7714
Wang, Li-Dong,Zhou, Fu-You,Li, Xue-Min,et al. Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54[J]. NATURE GENETICS,2010,42(9):759-U46.
APA Wang, Li-Dong.,Zhou, Fu-You.,Li, Xue-Min.,Sun, Liang-Dan.,Song, Xin.,...&Zhang, Xue-Jun.(2010).Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54.NATURE GENETICS,42(9),759-U46.
MLA Wang, Li-Dong,et al."Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54".NATURE GENETICS 42.9(2010):759-U46.
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