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学科主题: 临床医学
题名:
Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54
作者: Wang, Li-Dong1,2; Zhou, Fu-You2,3; Li, Xue-Min2,4; Sun, Liang-Dan5; Song, Xin1,2; Jin, Yan1; Li, Jiang-Man1,2; Kong, Guo-Qiang2; Qi, Hong2; Cui, Juan2; Zhang, Lian-Qun1; Yang, Jie-Zhi2; Li, Ji-Lin6; Li, Xing-Chuan2; Ren, Jing-Li2; Liu, Zhi-Cai7; Gao, Wen-Jun8; Yuan, Ling2,9; Wei, Wu10,11; Zhang, Yan-Rui12; Wang, Wei-Peng2,4; Sheyhidin, Ilyar13,14; Li, Feng15; Chen, Bao-Ping16; Ren, Shu-Wei17; Liu, Bin18; Li, Dan1,2; Ku, Jian-Wei19; Fan, Zong-Min2; Zhou, Sheng-Li1; Guo, Zhi-Gang1; Zhao, Xue-Ke1; Liu, Na1; Ai, Yong-Hong1; Shen, Fang-Fang1; Cui, Wen-Yan1; Song, Shuang2; Guo, Tao2; Huang, Jing2; Yuan, Chao2; Huang, Jia2; Wu, Yue2; Yue, Wen-Bin20; Feng, Chang-Wei2; Li, Hong-Lei2; Wang, Yan2; Tian, Jin-Ya2; Lu, Yue2; Yuan, Yi1; Zhu, Wen-Liang2; Liu, Min2; Fu, Wen-Jing2; Yang, Xia2; Wang, Han-Jing2; Han, Suo-Li2; Chen, Jie2; Han, Min21; Wang, Hai-Yan1; Zhang, Peng1; Li, Xiu-Min1; Dong, Jin-Cheng2; Xing, Guo-Lan2; Wang, Ran2; Guo, Ming2; Chang, Zhi-Wei2; Liu, Hai-Lin1; Guo, Li2; Yuan, Zhi-Qing1; Liu, Hai22; Lu, Qin2; Yang, Liu-Qin23; Zhu, Fu-Guo21; Yang, Xiu-Feng24; Feng, Xiao-Shan25; Wang, Zhou26; Li, Yin9; Gao, She-Gan25; Qige, Qirenwang27; Bai, Long-Tang27; Yang, Wen-Jun28; Lei, Guang-Yan29; Shen, Zhong-Ying30,31; Chen, Long-Qi32; Li, En-Min30,31; Xu, Li-Yan30,31; Wu, Zhi-Yong30,31; Cao, Wei-Ke33; Wang, Jian-Po2,3; Bao, Zhi-Qin4; Chen, Ji-Li4; Ding, Guang-Cheng2; Zhuang, Xiang2; Zhou, Ying-Fa2; Zheng, Hou-Feng5; Zhang, Zheng5; Zuo, Xian-Bo5; Dong, Zi-Ming2; Fan, Dong-Mei2; He, Xin2; Wang, Jin2; Zhou, Qi2; Zhang, Qin-Xian2; Jiao, Xin-Ying6; Lian, Shi-Yong7; Ji, Ai-Fang10,11; Lu, Xiao-Mei13,14; Wang, Jin-Sheng10,11; Chang, Fu-Bao8; Lu, Chang-Dong3; Chen, Zhi-Guo1; Miao, Jian-Jun4; Fan, Zeng-Lin4; Lin, Ruo-Bai34; Liu, Tai-Jiang35; Wei, Jin-Chang6; Kong, Qing-Peng36; Lan, Yu37; Fan, Yu-Jing37; Gao, Fu-Sheng18; Wang, Tian-Yun1; Xie, Dong38; Chen, Shu-Qing39; Yang, Wan-Cai1; Hong, Jun-Yan39; Wang, Liang1; Qiu, Song-Liang2; Cai, Zhi-Ming40; Zhang, Xue-Jun5
刊名: NATURE GENETICS
发表日期: 2010-09-01
DOI: 10.1038/ng.648
卷: 42, 期:9, 页:759-U46
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Genetics & Heredity
研究领域[WOS]: Genetics & Heredity
关键词[WOS]: PHOSPHOLIPASE-C-EPSILON ; HIGH-INCIDENCE AREA ; FUNCTIONAL-CHARACTERIZATION ; NORTHERN CHINA ; RISK-FACTORS ; HAN CHINESE ; CANCER
英文摘要:

We performed a genome-wide association study of esophageal squamous cell carcinoma (ESCC) by genotyping 1,077 individuals with ESCC and 1,733 control subjects of Chinese Han descent. We selected 18 promising SNPs for replication in an additional 7,673 cases of ESCC and 11,013 control subjects of Chinese Han descent and 303 cases of ESCC and 537 control subjects of Chinese Uygur-Kazakh descent. We identified two previously unknown susceptibility loci for ESCC: PLCE1 at 10q23 (P(Han combined) (for ESCC) = 7.46 x 10(-56), odds ratio (OR) = 1.43; P(Uygur-Kazakh for ESCC) = 5.70 x 10(-4), OR = 1.53) and C20orf54 at 20p13 (P(Han combined) (for ESCC) = 1.21 x 10(-11), OR = 0.86; P(Uygur-Kazakh for ESCC) = 7.88 x 10(-3), OR = 0.66). We also confirmed association in 2,766 cases of gastric cardia adenocarcinoma cases and the same 11,013 control subjects (PLCE1, P(Han for GCA) = 1.74 x 10(-39), OR = 1.55 and C20orf54, P(Han for GCA) = 3.02 x 10(-3), OR = 0.91). PLCE1 and C20orf54 have important biological implications for both ESCC and GCA. PLCE1 might regulate cell growth, differentiation, apoptosis and angiogenesis. C20orf54 is responsible for transporting riboflavin, and deficiency of riboflavin has been documented as a risk factor for ESCC and GCA.

语种: 英语
所属项目编号: 2009-5 ; 30670956 ; 30971133 ; 2006AA02A403 ; 2007AA02Z161 ; 2007CB516812 ; 2009-8 ; 2009-10 ; 2008-7 ; 2007-7
项目资助者: Xinxiang Medical University ; National Natural Science Foundations ; 863 HighTech Key Projects ; China Key Program on Basic Research ; Science and Technology Department of Henan Province ; Health Department of Henan Province ; Education Department of Henan Province ; Anhui Provincial Special Scientific Program
WOS记录号: WOS:000281388400010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58001
Appears in Collections:北京大学深圳医院_期刊论文

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作者单位: 1.Xinyang Cent Hosp, Dept Oncol, Xinyang, Henan, Peoples R China
2.Peoples Hosp Puyang, Dept Oncol, Puyang, Henan, Peoples R China
3.Xinxiang Med Univ, Canc Res Ctr, Xinxiang, Henan, Peoples R China
4.Tumor Hosp Linzhou, Dept Thorac Surg, Linzhou, Henan, Peoples R China
5.Changzhi Med Univ, Inst Hematol Dis, Changzhi, Shanxi, Peoples R China
6.Changzhi Med Univ, Dept Pathol, Changzhi, Shanxi, Peoples R China
7.Zhengzhou Univ, Henan Key Lab Esophageal Canc Res, Dept Basic Oncol & Pathol, Coll Med,Affiliated Hosp 1& 2, Zhengzhou, Henan, Peoples R China
8.Anyang Tumor Hosp, Dept Thorac Surg & Tumor Prevent Treatment, Anyang, Henan, Peoples R China
9.Cixian Hosp, Dept Pathol & Thorac Surg, Ctr Hlth Screening & Endoscopy, Cixian, Hebei, Peoples R China
10.Anhui Med Univ, Minist Educ, Key Lab Dermatol, Hefei, Anhui, Peoples R China
11.Linzhou Esophageal Canc Hosp, Dept Pathol & Thorac Surg, Linzhou, Henan, Peoples R China
12.Peoples Hosp & Chinese Med Hosp Linzhou, Dept Thorac Surg, Linzhou, Henan, Peoples R China
13.Canc Hosp Henan Prov, Dept Thorac Surg & Radiotherapy, Zhengzhou, Henan, Peoples R China
14.Henan Prov Peoples Hosp, Dept Gastroenterol, Zhengzhou, Henan, Peoples R China
15.Xinjiang Med Univ, Affiliated Hosp 1, Dept Thorac Surg, Urumqi, Xinjiang, Peoples R China
16.Xinjiang Med Univ, Affiliated Hosp 1, Med Res Ctr, Urumqi, Xinjiang, Peoples R China
17.Shihezi Univ, Sch Med, Dept Pathol, Shihezi, Xinjiang, Peoples R China
18.Henan Univ, Huaihe Hosp, Dept Nephrol, Kaifeng, Henan, Peoples R China
19.Capital Med Univ, Beijing Tongren Hosp, Dept Gastroenterol, Beijing, Peoples R China
20.Nanyang Med Coll, Affiliated Hosp 1, Dept Oncol, Nanyang, Henan, Peoples R China
21.First Peoples Hosp Shangqiu, Dept Gastroenterol & Thorac Surg, Shangqiu, Henan, Peoples R China
22.Third Peoples Hosp Yunnan Prov, Dept Gastroenterol, Kunming, Yunnan, Peoples R China
23.Cent Hosp Xinxiang, Dept Radiotherapy, Xinxiang, Henan, Peoples R China
24.Hebi Dahejian Hosp, Dept Surg, Hebi, Henan, Peoples R China
25.Henan Univ Sci & Technol, Affiliated Hosp 1, Dept Oncol, Luoyang, Henan, Peoples R China
26.Shandong Univ, Dept Thorac Surg, Prov Hosp, Jinan 250100, Shandong, Peoples R China
27.Inner Mongolia Med Coll, Affiliated Hosp, Dept Internal Mongolia Med, Hohhot, Inner Mongolia, Peoples R China
28.Ningxia Med Univ, Dept Biotechnol, Ningxia, Peoples R China
29.Tumor Hosp Shaanxi Prov, Dept Thorac Surg, Xian, Shaanxi, Peoples R China
30.Shantou Univ, Coll Med, Dept Oncol Pathol, Shantou, Guangdong, Peoples R China
31.Shantou Univ, Coll Med, Dept Biochem & Mol Biol, Shantou, Guangdong, Peoples R China
32.Sichuan Univ, W China Hosp, Dept Thorac & Cardiovasc Surg, Chengdu 610064, Sichuan, Peoples R China
33.Nanjing Med Univ, Huaian Hosp 1, Cent Lab, Huaian, Jiangsu, Peoples R China
34.Fujian Med Univ, Dept Thorac Surg, Union Hosp, Fuzhou, Fujian, Peoples R China
35.Red Cross Hosp Huojia, Dept Surg, Xinxiang, Henan, Peoples R China
36.Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resource & Evolut, Kunming, Yunnan, Peoples R China
37.Peking Univ, Med Coll 4, Beijing Jishuitan Hosp, Dept Gastroenterol, Beijing 100871, Peoples R China
38.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai, Peoples R China
39.Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310003, Zhejiang, Peoples R China
40.Peking Univ, Shenzhen Hosp, Guangdong Key Lab Male Reprod Med & Genet, Shenzhen, Guangdong, Peoples R China

Recommended Citation:
Wang, Li-Dong,Zhou, Fu-You,Li, Xue-Min,et al. Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54[J]. NATURE GENETICS,2010,42(9):759-U46.
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