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学科主题: 精神卫生
题名:
Low BDNF is associated with cognitive impairment in chronic patients with schizophrenia
作者: Zhang, Xiang Yang1,4; Liang, Jun3; Chen, Da Chun2; Xiu, Mei Hong2; Yang, Fu De2; Kosten, Therese A.4; Kosten, Thomas R.1,4
关键词: Schizophrenia ; Cognition ; Brain-derived neurotrophic factor ; Serum
刊名: PSYCHOPHARMACOLOGY
发表日期: 2012-07-01
DOI: 10.1007/s00213-012-2643-y
卷: 222, 期:2, 页:277-284
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]: Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]: NEUROTROPHIC FACTOR LEVELS ; LONG-TERM TREATMENT ; LOW SERUM-LEVELS ; BIPOLAR DISORDER ; 1ST-EPISODE SCHIZOPHRENIA ; NEUROPSYCHOLOGICAL STATUS ; ATYPICAL ANTIPSYCHOTICS ; VAL66MET POLYMORPHISM ; TARDIVE-DYSKINESIA ; REPEATABLE BATTERY
英文摘要:

Several lines of evidence suggest that brain-derived neurotrophic factor (BDNF) plays a critical role in activity-dependent neuroplasticity underlying learning and memory in the hippocampus. Schizophrenia has a range of cognitive deficits that may evolve from decreased BDNF, and this study examines this association of BDNF with cognitive deficits in schizophrenia.

We recruited 251 chronic schizophrenic patients and 206 healthy control subjects and examined the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and serum BDNF in both groups. Schizophrenic symptoms were assessed using the Positive and Negative Syndrome Scale.

BDNF levels were significantly lower in patients than controls (p < 0.001). Cognitive scores on the RBANS and nearly all of its five subscales (all p < 0.001) except for the visuospatial/constructional index (p > 0.05) were significantly lower in schizophrenic patients than normal controls. For the patients, BDNF was positively associated with immediate memory in schizophrenia.

Our findings suggest that BDNF may be involved in the pathophysiology of schizophrenia, and its associated cognitive impairment, especially immediate memory.

语种: 英语
所属项目编号: 03T-459 ; 05T-726 ; K05-DA0454 ; P50-DA18827 ; U01-MH79639
项目资助者: Stanley Medical Research Institute ; Department of Veterans Affairs, VISN 16, Mental Illness Research, Education and Clinical Center (MIRECC), United States National Institute of Health
WOS记录号: WOS:000305681600009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58003
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China
2.Beijing HuiLongGuan Hosp, Beijing 100096, Peoples R China
3.VA Med Ctr, Houston, TX 77030 USA
4.Baylor Coll Med, Menninger Dept Psychiat & Behav Sci, Houston, TX 77030 USA

Recommended Citation:
Zhang, Xiang Yang,Liang, Jun,Chen, Da Chun,et al. Low BDNF is associated with cognitive impairment in chronic patients with schizophrenia[J]. PSYCHOPHARMACOLOGY,2012,222(2):277-284.
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