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Low BDNF is associated with cognitive impairment in chronic patients with schizophrenia
Zhang, Xiang Yang1,4; Liang, Jun3; Chen, Da Chun2; Xiu, Mei Hong2; Yang, Fu De2; Kosten, Therese A.4; Kosten, Thomas R.1,4
关键词Schizophrenia Cognition Brain-derived Neurotrophic Factor Serum
刊名PSYCHOPHARMACOLOGY
2012-07-01
DOI10.1007/s00213-012-2643-y
222期:2页:277-284
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]NEUROTROPHIC FACTOR LEVELS ; LONG-TERM TREATMENT ; LOW SERUM-LEVELS ; BIPOLAR DISORDER ; 1ST-EPISODE SCHIZOPHRENIA ; NEUROPSYCHOLOGICAL STATUS ; ATYPICAL ANTIPSYCHOTICS ; VAL66MET POLYMORPHISM ; TARDIVE-DYSKINESIA ; REPEATABLE BATTERY
英文摘要

Several lines of evidence suggest that brain-derived neurotrophic factor (BDNF) plays a critical role in activity-dependent neuroplasticity underlying learning and memory in the hippocampus. Schizophrenia has a range of cognitive deficits that may evolve from decreased BDNF, and this study examines this association of BDNF with cognitive deficits in schizophrenia.

We recruited 251 chronic schizophrenic patients and 206 healthy control subjects and examined the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and serum BDNF in both groups. Schizophrenic symptoms were assessed using the Positive and Negative Syndrome Scale.

BDNF levels were significantly lower in patients than controls (p < 0.001). Cognitive scores on the RBANS and nearly all of its five subscales (all p < 0.001) except for the visuospatial/constructional index (p > 0.05) were significantly lower in schizophrenic patients than normal controls. For the patients, BDNF was positively associated with immediate memory in schizophrenia.

Our findings suggest that BDNF may be involved in the pathophysiology of schizophrenia, and its associated cognitive impairment, especially immediate memory.

语种英语
WOS记录号WOS:000305681600009
项目编号03T-459 ; 05T-726 ; K05-DA0454 ; P50-DA18827 ; U01-MH79639
资助机构Stanley Medical Research Institute ; Department of Veterans Affairs, VISN 16, Mental Illness Research, Education and Clinical Center (MIRECC), United States National Institute of Health
引用统计
被引频次:58[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58003
专题北京大学精神卫生研究所
作者单位1.Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China
2.Beijing HuiLongGuan Hosp, Beijing 100096, Peoples R China
3.VA Med Ctr, Houston, TX 77030 USA
4.Baylor Coll Med, Menninger Dept Psychiat & Behav Sci, Houston, TX 77030 USA
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GB/T 7714
Zhang, Xiang Yang,Liang, Jun,Chen, Da Chun,et al. Low BDNF is associated with cognitive impairment in chronic patients with schizophrenia[J]. PSYCHOPHARMACOLOGY,2012,222(2):277-284.
APA Zhang, Xiang Yang.,Liang, Jun.,Chen, Da Chun.,Xiu, Mei Hong.,Yang, Fu De.,...&Kosten, Thomas R..(2012).Low BDNF is associated with cognitive impairment in chronic patients with schizophrenia.PSYCHOPHARMACOLOGY,222(2),277-284.
MLA Zhang, Xiang Yang,et al."Low BDNF is associated with cognitive impairment in chronic patients with schizophrenia".PSYCHOPHARMACOLOGY 222.2(2012):277-284.
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