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学科主题临床医学
Association studies of genetic polymorphism, environmental factors and their interaction in ischemic stroke
Gao, XG; Huo, Y; Teng, ZP
关键词Ischemic Stroke Polymorphism Ace Apoe Fg Beta Mthfr
刊名NEUROSCIENCE LETTERS
2006-05-08
DOI10.1016/j.neulet.2005.12.078
398期:3页:172-177
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]APOLIPOPROTEIN-E POLYMORPHISM ; BETA-FIBRINOGEN ; DELETION POLYMORPHISM ; PLASMA-FIBRINOGEN ; YOUNG-ADULTS ; RISK ; GENOTYPES ; HOMOCYSTEINE ; PREVENTION ; DISEASE
英文摘要

Genetic back-round plays an important role in susceptibility to ischemic stroke. Our aim was to investigate the association of genetic polymorphisms and ischemic stroke and to evaluate their interaction with environmental risk factors in the Chinese population. Angiotensin-converting enzyme (ACE) gene I/D polymorphism, apolipoprotein E (ApoE) gene polymorphism, methylenetetrahydrofolate reductase (MTHFR) gene 677C/T polymorphism, and beta fibrinogen (Fg beta) gene 148C/T polymorphism were analyzed in 100 patients and 100 matched controls. The subjects were genotyped by polymerase chain reaction (PCR) amplification and denaturing high-performance liquid chromatography (DHPLC) analysis. Persons with the Fg beta CT/TT, MTHFR CT/TT, and ACE ID/DD genotypes had an elevated incidence of ischemic stroke (OR 3.907, 95% Cl, 1.160-13.162, P = 0.028). Smokers with the Fg beta CT/TT or APOE epsilon 4 epsilon 3 genotype, as well as individuals with the F.-P CT/TT genotype who consumed alcohol were more likely to develop a stroke. The data indicate that certain unfavorable genotypic combinations act synergistically in the development of ischemic stroke in the Chinese population. Synergism was also observed between genotype and environmental risk factors. This study may facilitate the development of a strategy to effectively prevent ischemic strokes. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000237434000003
引用统计
被引频次:56[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58005
专题北京大学第二临床医学院_神经内科
作者单位1.Peking Univ, Peoples Hosp, Dept Neurol, Beijing 100044, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Hematol, Beijing, Peoples R China
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Gao, XG,Huo, Y,Teng, ZP. Association studies of genetic polymorphism, environmental factors and their interaction in ischemic stroke[J]. NEUROSCIENCE LETTERS,2006,398(3):172-177.
APA Gao, XG,Huo, Y,&Teng, ZP.(2006).Association studies of genetic polymorphism, environmental factors and their interaction in ischemic stroke.NEUROSCIENCE LETTERS,398(3),172-177.
MLA Gao, XG,et al."Association studies of genetic polymorphism, environmental factors and their interaction in ischemic stroke".NEUROSCIENCE LETTERS 398.3(2006):172-177.
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