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Highly Efficient and Mild Method for Regioselective De-O-benzylation of Saccharides by Co-2(CO)(8)-Et3SiH-CO Reagent System
Yin, Zhao-Jun; Wang, Bo; Li, Yang-Bing; Meng, Xiang-Bao; Li, Zhong-Jun
刊名ORGANIC LETTERS
2010-02-05
DOI10.1021/ol902717y
12期:3页:536-539
收录类别SCI ; IC ; CCR
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Organic
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
研究领域[WOS]Chemistry
关键词[WOS]C-GLYCOSYL COMPOUNDS ; DISACCHARIDE DERIVATIVES ; SELECTIVE DEBENZYLATION ; RAFFINOSE CHEMISTRY ; STRUCTURAL-ANALYSIS ; TRITYLATED SUCROSE ; CATALYTIC TRANSFER ; HIGHER ANALOGS ; ETHERS ; MONO
英文摘要

A highly efficient and mild method for the de-O-benzylation of protected saccharides was developed by transforming terminal benzyl ethers into silyl ethers using Co-2(CO)(8)-Et3SiH under 1 atm of CO. The method was successfully used for the de-O-benzylation of perbenzylated monosaccharides with various anomeric protecting groups, as well as natural disaccharides and trisaccharides such as sucrose, raffinose, and melezitose in good yields (>80%).

语种英语
所属项目编号20732001 ; 90713004 ; 30672525
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS记录号WOS:000273982600035
Citation statistics
Cited Times:12[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58012
Collection北京大学药学院
作者单位Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Yin, Zhao-Jun,Wang, Bo,Li, Yang-Bing,et al. Highly Efficient and Mild Method for Regioselective De-O-benzylation of Saccharides by Co-2(CO)(8)-Et3SiH-CO Reagent System[J]. ORGANIC LETTERS,2010,12(3):536-539.
APA Yin, Zhao-Jun,Wang, Bo,Li, Yang-Bing,Meng, Xiang-Bao,&Li, Zhong-Jun.(2010).Highly Efficient and Mild Method for Regioselective De-O-benzylation of Saccharides by Co-2(CO)(8)-Et3SiH-CO Reagent System.ORGANIC LETTERS,12(3),536-539.
MLA Yin, Zhao-Jun,et al."Highly Efficient and Mild Method for Regioselective De-O-benzylation of Saccharides by Co-2(CO)(8)-Et3SiH-CO Reagent System".ORGANIC LETTERS 12.3(2010):536-539.
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