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学科主题: 临床医学
题名:
Circulating miR-19a and miR-205 in Serum May Predict the Sensitivity of Luminal A Subtype of Breast Cancer Patients to Neoadjuvant Chemotherapy with Epirubicin Plus Paclitaxel
作者: Li, Qian1,2,3,7; Liu, Mei2,3,4,5; Ma, Fei1,2,3; Luo, Yang1,2,3; Cai, Ruigang1,2,3; Wang, Liming2,3,6; Xu, Ningzhi2,3,4,5; Xu, Binghe1,2,3
刊名: PLOS ONE
发表日期: 2014-08-19
DOI: 10.1371/journal.pone.0104870
卷: 9, 期:8
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: MICRORNA EXPRESSION ; PROGNOSTIC-SIGNIFICANCE ; ADJUVANT CHEMOTHERAPY ; IDENTIFICATION ; RESISTANCE ; CELLS ; GENE ; TRASTUZUMAB ; PATHWAY ; MARKERS
英文摘要:

Background: The luminal A subtype of breast cancer has a good prognosis and is sensitive to endocrine therapy but is less sensitive to chemotherapy. It is necessary to identify biomarkers to predict chemosensitivity and avoid over-treatment. We hypothesized that miRNAs in the serum might be associated with chemosensitivity.

Methods: Sixty-eight breast cancer patients received neoadjuvant chemotherapy with epirubicin plus paclitaxel. The serum of the patients was collected before chemotherapy and stored at -80 degrees C. The samples were classified into two groups in term of the chemosensitivity. We identified the differential expression patterns of miRNAs between the chemotherapy sensitive and resistant groups using microRNA profiling. Four miRNAs that were differentially expressed between the two groups were further validated in another 56 samples. We created a model fitting formula and a receiver operating characteristics (ROC) curve using logistic regression analysis to evaluate the prediction potency.

Results: We identified 8 miRNAs differentially expressed between the two groups: 6 miRNAs were up-regulated, and 2 miRNAs were down-regulated in the resistant group compared with the sensitive group. The expression of miR-19a and miR-205 were determined to have significant differences between the two groups (P<0.05). A predictive model of these two miRNAs was created by the logistic regression analysis. The probability of this model was 89.71%. Based on the ROC curve, the specificity was 75.00%, and the sensitivity was 81.25%.

Conclusions: The combination of miR-19a and miR-205 in the serum may predict the chemosensitivity of luminal A subtype of breast cancer to epirubicin plus paclitaxel neoadjuvant chemotherapy.

语种: 英语
所属项目编号: 81372830 ; LC2013L09 ; Z141107002514010
项目资助者: National Natural Science Foundation ; Beijing Hope Run Special Fund ; Capital Clinical Feature Applied Research Fund
WOS记录号: WOS:000340742100050
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58013
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: 1.Chinese Acad Med Sci, Inst Canc, Dept Med Oncol, Beijing 100021, Peoples R China
2.Chinese Acad Med Sci, Canc Hosp, Beijing 100021, Peoples R China
3.Peking Union Med Coll, Beijing 100021, Peoples R China
4.Chinese Acad Med Sci, Inst Canc, Lab Cell & Mol Biol, Beijing 100021, Peoples R China
5.Chinese Acad Med Sci, Inst Canc, State Key Lab Mol Oncol, Beijing 100021, Peoples R China
6.Chinese Acad Med Sci, Inst Canc, Dept Abdominal Surg, Beijing 100021, Peoples R China
7.Peking Univ, Hosp 3, Dept Tumor Chemotherapy & Radiat Sickness, Beijing 100871, Peoples R China

Recommended Citation:
Li, Qian,Liu, Mei,Ma, Fei,et al. Circulating miR-19a and miR-205 in Serum May Predict the Sensitivity of Luminal A Subtype of Breast Cancer Patients to Neoadjuvant Chemotherapy with Epirubicin Plus Paclitaxel[J]. PLOS ONE,2014,9(8).
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