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Hypoglycemic effect of Ganoderma lucidum polysaccharides
Zhang, HN; Lin, ZB
关键词Ganoderma Lucidum Polysaccharides Hypoglycemic Agents Glucose Insulin Calcium Pancreas
刊名ACTA PHARMACOLOGICA SINICA
2004-02-01
25期:2页:191-195
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]Chemistry ; Pharmacology & Pharmacy
关键词[WOS]SECRETION ; PLANTS
英文摘要

AIM: To investigate the hypoglycemic effect of Ganoderma lucidum polysaccharides (Gl-PS) in the normal fasted mice and its possible mechanism. METHODS: Normal fasted mice were given a single dose of Gl-PS 25, 50, and 100 mg/kg by ip and the serum glucose was measured at 0, 3, and 6 h after administration. Gl-PS 100 mg/kg were also given by ip and the serum glucose and insulin levels were measured at 0 min, 30 min, 1 h, 3 h, 6 h, and 12 h. Pancreatic islets were isolated and incubated with glucose 5.6 mmol/L and different concentration of Gl-PS, the insulin content of islets and insulin release were examined. The islets fluorescent intensity of [Ca2+](i) was also studied with a confocal microscope. Verapamil and egtazic acid were used to testify whether the insulin-releasing effect of Gl-PS was mediated by its ability to raise the Ca2+ influx. RESULTS: Gl-PS dose-dependently lowered the serum glucose levels at 3 h and 6 h after administration. Gl-PS 100 mg/kg raised the circulating insulin levels at 1 h after administration. In vitro, Gl-PS had no effect on islets insulin content, but it stimulated the insulin release after incubation with glucose 5.6 mmol/L. Confocal microscope showed that Gl-PS 100 mg/L had the capacity to raise the [Ca2+](i). The insulin-releasing effect of Gl-PS was inhibited by verapamil/egtazic acid. CONCLUSION: Gl-PS possesses the hypoglycemic effect on normal mice; one mechanism is through its insulin-releasing activity due to a facilitation of Ca2+ inflow to the pancreatic beta cells.

语种中文
WOS记录号WOS:000188877300011
引用统计
被引频次:46[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58016
专题基础医学院_药理学系
作者单位Peking Univ, Dept Pharmacol, Sch Basic Med Sci, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Zhang, HN,Lin, ZB. Hypoglycemic effect of Ganoderma lucidum polysaccharides[J]. ACTA PHARMACOLOGICA SINICA,2004,25(2):191-195.
APA Zhang, HN,&Lin, ZB.(2004).Hypoglycemic effect of Ganoderma lucidum polysaccharides.ACTA PHARMACOLOGICA SINICA,25(2),191-195.
MLA Zhang, HN,et al."Hypoglycemic effect of Ganoderma lucidum polysaccharides".ACTA PHARMACOLOGICA SINICA 25.2(2004):191-195.
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