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学科主题: 基础医学
题名:
Hypoglycemic effect of Ganoderma lucidum polysaccharides
作者: Zhang, HN; Lin, ZB
关键词: Ganoderma lucidum ; polysaccharides ; hypoglycemic agents ; glucose ; insulin ; calcium ; pancreas
刊名: ACTA PHARMACOLOGICA SINICA
发表日期: 2004-02-01
卷: 25, 期:2, 页:191-195
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: SECRETION ; PLANTS
英文摘要:

AIM: To investigate the hypoglycemic effect of Ganoderma lucidum polysaccharides (Gl-PS) in the normal fasted mice and its possible mechanism. METHODS: Normal fasted mice were given a single dose of Gl-PS 25, 50, and 100 mg/kg by ip and the serum glucose was measured at 0, 3, and 6 h after administration. Gl-PS 100 mg/kg were also given by ip and the serum glucose and insulin levels were measured at 0 min, 30 min, 1 h, 3 h, 6 h, and 12 h. Pancreatic islets were isolated and incubated with glucose 5.6 mmol/L and different concentration of Gl-PS, the insulin content of islets and insulin release were examined. The islets fluorescent intensity of [Ca2+](i) was also studied with a confocal microscope. Verapamil and egtazic acid were used to testify whether the insulin-releasing effect of Gl-PS was mediated by its ability to raise the Ca2+ influx. RESULTS: Gl-PS dose-dependently lowered the serum glucose levels at 3 h and 6 h after administration. Gl-PS 100 mg/kg raised the circulating insulin levels at 1 h after administration. In vitro, Gl-PS had no effect on islets insulin content, but it stimulated the insulin release after incubation with glucose 5.6 mmol/L. Confocal microscope showed that Gl-PS 100 mg/L had the capacity to raise the [Ca2+](i). The insulin-releasing effect of Gl-PS was inhibited by verapamil/egtazic acid. CONCLUSION: Gl-PS possesses the hypoglycemic effect on normal mice; one mechanism is through its insulin-releasing activity due to a facilitation of Ca2+ inflow to the pancreatic beta cells.

语种: 中文
WOS记录号: WOS:000188877300011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58016
Appears in Collections:基础医学院_药理学系_期刊论文

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作者单位: Peking Univ, Dept Pharmacol, Sch Basic Med Sci, Beijing 100083, Peoples R China

Recommended Citation:
Zhang, HN,Lin, ZB. Hypoglycemic effect of Ganoderma lucidum polysaccharides[J]. ACTA PHARMACOLOGICA SINICA,2004,25(2):191-195.
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