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学科主题: 临床医学
题名:
Keratitis by Fusarium temperatum, a novel opportunist
作者: Al-Hatmi, Abdullah M. S.1,2,3; Bonifaz, Alexandro4; de Hoog, G. Sybren1,2,5,6,7,8,9; Vazquez-Maya, Leticia4; Garcia-Carmona, Karla4; Meis, Jacques F.10,11; van Diepeningen, Anne D.1
关键词: Keratitis ; Fusarium temperatum ; Maize ; Molecular phylogenetics ; Infection
刊名: BMC INFECTIOUS DISEASES
发表日期: 2014-11-12
DOI: 10.1186/s12879-014-0588-y
卷: 14
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Infectious Diseases
研究领域[WOS]: Infectious Diseases
关键词[WOS]: SOLANI SPECIES COMPLEX ; DNA-SEQUENCE DATABASE ; FUNGAL KERATITIS ; SP-NOV ; INFECTIONS ; PLANTS ; SUBGLUTINANS ; SPECTRUM ; INDIA ; SUSCEPTIBILITY
英文摘要:

Background: Fusarium species are among the most common fungi present in the environment and some species have emerged as major opportunistic fungal infection in human. However, in immunocompromised hosts they can be virulent pathogens and can cause death. The pathogenesis of this infection relies on three factors: colonization, tissue damage, and immunosuppression. A novel Fusarium species is reported for the first time from keratitis in an agriculture worker who acquired the infection from plant material of maize. Maize plants are the natural host of this fungus where it causes stalk rot and seeding malformation under temperate and humid climatic conditions. The clinical manifestation, microbiological morphology, physiological features and molecular data are described.

Methods: Diagnosis was established by using polymerase chain reaction of fungal DNA followed by sequencing portions of translation elongation factor 1 alpha (TEF1 alpha) and beta-tubulin (BT2) genes. Susceptibility profiles of this fungus were evaluated using CLSI broth microdilution method.

Results: The analyses of these two genes sequences support a novel opportunist with the designation Fusarium temperatum. Phylogenetic analyses showed that the reported clinical isolate was nested within the Fusarium fujikuroi species complex. Antifungal susceptibility testing demonstrated that the fungus had low MICs of micafungin (0.031 mu g/ml), posaconazole (0.25 mu g/ml) and amphotericin B (0.5 mu g/ml).

Conclusion: The present case extends the significance of the genus Fusarium as agents of keratitis and underscores the utility of molecular verification of these emerging fungi in the human host.

语种: 英语
项目资助者: Ministry of Health, Muscat, Oman
WOS记录号: WOS:000344963100001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58023
Appears in Collections:北京大学第一临床医学院_皮肤性病科_期刊论文

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作者单位: 1.CBS KNAW Fungal Biodivers Ctr, NL-3508 AD Utrecht, Netherlands
2.Minist Hlth, Ibri Hosp, Directorate Gen Hlth Serv, Muscat, Oman
3.Hosp Gen Mexico City, OD, Mexico City, DF, Mexico
4.King Abdulaziz Univ, Jeddah 21413, Saudi Arabia
5.Univ Amsterdam, Inst Biodivers & Ecosyst Dynam, Amsterdam, Netherlands
6.Peking Univ, Hlth Sci Ctr, Res Ctr Med Mycol, Beijing 100871, Peoples R China
7.Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Guangzhou 510275, Guangdong, Peoples R China
8.Second Mil Med Univ, Changzheng Hosp, Shanghai Inst Med Mycol, Shanghai, Peoples R China
9.Univ Fed Parana, Basic Pathol Dept, Curitiba, Parana, Brazil
10.Canisius Wilhelmina Hosp, Dept Med Microbiol & Infect Dis, Nijmegen, Netherlands
11.Radboud Univ Nijmegen, Med Ctr, Dept Med Microbiol, NL-6525 ED Nijmegen, Netherlands

Recommended Citation:
Al-Hatmi, Abdullah M. S.,Bonifaz, Alexandro,de Hoog, G. Sybren,et al. Keratitis by Fusarium temperatum, a novel opportunist[J]. BMC INFECTIOUS DISEASES,2014,14.
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