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学科主题: 临床医学
题名:
Impact of the leucocyte immunoglobulin-like receptor A3 (LILRA3) on susceptibility and subphenotypes of systemic lupus erythematosus and Sjogren′s syndrome
作者: Du, Yan1; Su, Yin1; He, Jing1; Yang, Yue1; Shi, Yamei2; Cui, Yong3; Luo, Cainan2; Wu, Xinyu1; Liu, Xu1; Hu, Fanlei1; Ma, Xiaoxu1; Zheng, Li1; Zhang, Jing1; Zuo, Xianbo3; Sheng, Yujun3; Wu, Lijun2; Zhang, Xuejun3; Guo, Jianping1; Li, Zhanguo1
刊名: ANNALS OF THE RHEUMATIC DISEASES
发表日期: 2015-11-01
DOI: 10.1136/annrheumdis-2013-204441
卷: 74, 期:11, 页:2070-2075
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Rheumatology
研究领域[WOS]: Rheumatology
关键词[WOS]: CLASS-I MOLECULES ; RHEUMATOID-ARTHRITIS ; MULTIPLE-SCLEROSIS ; ASSOCIATION ; CLASSIFICATION ; DEFICIENCY ; SELECTION ; DELETION ; CRITERIA ; PROTEIN
英文摘要:

Background Recently, our research group identified the non-deleted (functional) leucocyte immunoglobulin-like receptor A3 (LILRA3) as a new genetic risk for rheumatoid arthritis.

Objectives To further investigate whether the functional LILRA3 is a new susceptibility factor for other autoimmune diseases for example, systemic lupus erythematosus (SLE) and primary Sjogren′s syndrome (pSS).

Methods The LILRA3 deletion polymorphism and its tagging single nucleotide polymorphism rs103294 were genotyped for 1099 patients with SLE, 403 patients with pSS and 2169 healthy controls. Association analyses were performed in whole dataset or clinical/serological subsets. The impact of LILRA3 on SLE activity and LILRA3 expression was evaluated.

Results The functional LILRA3 conferred high susceptibility to both SLE (p=3.51x10(-7), OR=2.03) and pSS (p=1.40x10(-3), OR=2.32). It was associated with almost all the clinical/serological features in SLE, especially with leucopenia (p=4.09x10(-7), OR=2.19) and thrombocytopenia (p=1.68x10(-5), OR=1.70). In pSS, functional LILRA3 was specifically associated with leucopenia (p=4.39x10(-4), OR=3.25), anti-Ro/SSA-positive subphenotypes (p=4.54x10(-3), OR=2.34) and anti-La/SSB-positive subphenotypes (p=0.012, OR=2.49). Functional LILRA3 conferred higher disease activity in patients with SLE (p=0.044) and higher LILRA3 expression in both SLE (p=5.57x10(-8)) and pSS (p=1.49x10(-7)) than in controls.

Conclusions Functional LILRA3 is a new susceptibility factor for SLE and pSS. It highly predisposes to certain phenotypes such as leucopenia and thrombocytopenia in SLE, and may confer increased disease activity in SLE and a higher risk of leucopenia and autoantibody-positive subphenotypes in pSS.

语种: 英语
所属项目编号: 2010CB529105 ; 2014CB541901 ; 2010DFB34000 ; 81120108020 ; 31270914 ; 81071940 ; NCET-12-0600 ; 7122196
项目资助者: National Key Basic Research Program of China (973 program) ; Program of International Science &amp ; Technology Cooperation of MOST ; Major International Joint Research Project of NSFC ; National Natural Science Foundation of China ; Education Ministry&prime ; s New Century Outstanding Talents Supporting Plan ; Beijing Natural Science Foundation
WOS记录号: WOS:000363348800018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58029
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Peking Univ, Dept Rheumatol & Immunol, Peoples Hosp, Beijing 100044, Peoples R China
2.Peoples Hosp Xinjiang Uygur Autonomous Reg, Dept Rheumatol & Immunol, Urumqi, Peoples R China
3.Anhui Med Univ, Inst Dermatol, Hosp 1, Dept Dermatol, Hefei, Peoples R China

Recommended Citation:
Du, Yan,Su, Yin,He, Jing,et al. Impact of the leucocyte immunoglobulin-like receptor A3 (LILRA3) on susceptibility and subphenotypes of systemic lupus erythematosus and Sjogren′s syndrome[J]. ANNALS OF THE RHEUMATIC DISEASES,2015,74(11):2070-2075.
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